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Mashup Score: 5
Key PointsOnly ≤21% of patients achieved sustained response at week 52 with dapsone, with frequent early withdrawals because of adverse events.Dapsone risk
Source: ashpublications.orgCategories: General Medicine NewsTweet
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Mashup Score: 3Hepatosplenic T-cell lymphoma in children and adolescents - 2 day(s) ago
Abstract. Hepatosplenic T-cell lymphoma (HSTCL) is an aggressive mature T-cell lymphoma characterized by significant hepatosplenomegaly, bone marrow involv
Source: ashpublications.orgCategories: General Medicine NewsTweet-
Hepatosplenic T-cell lymphoma is an aggressive mature T-cell lymphoma characterized by significant hepatosplenomegaly, bone marrow involvement, and minimal or no lymphadenopathy. https://t.co/Ei0yCQm3Tj #clinicaltrialsandobservations #lymphoidneoplasia https://t.co/6YWQz7pxUy
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Mashup Score: 7Patient-reported improvements in paroxysmal nocturnal hemoglobinuria treated with iptacopan from 2 phase 3 studies - 2 day(s) ago
Key PointsPatients with PNH treated with iptacopan experience meaningful improvement in fatigue and quality of life.In complement inhibitor–experienced pat
Source: ashpublications.orgCategories: General Medicine News, Onc News and JournalsTweet-
Patients with PNH treated with iptacopan experience meaningful improvement in fatigue and quality of life. https://t.co/RODPgvE7Nb #clinicaltrialsandobservations https://t.co/qIgXh20nny
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Mashup Score: 3
Key PointsTBL1X plays a multifaceted role in promoting the proliferation and survival of MCL cells.Targeting TBL1X promotes destabilization of cyclin D1 an
Source: ashpublications.orgCategories: General Medicine NewsTweet-
Targeting TBL1X promotes destabilization of cyclin D1 and RAD51, resulting in cell cycle arrest, DNA damage, and MCL cell death. https://t.co/K9JF0BHFHQ #lymphoidneoplasia https://t.co/MGks8tQQAy
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Mashup Score: 20Large clones of clonal hematopoiesis affect outcome in mantle cell lymphoma: results from the FIL MCL0208 clinical trial - 3 day(s) ago
Key PointsYoung untreated patients with MCL show 13% prevalence of M-CH at baseline.Large M-CH clones (variant allele frequency ≥ 10%) are associated with
Source: ashpublications.orgCategories: General Medicine NewsTweet-
Large M-CH clones (variant allele frequency ≥ 10%) are associated with MCL progression and worse progression-free and overall survival. https://t.co/ZWPgjRc77b #lymphoidneoplasia #healthservicesandoutcomes https://t.co/TNfMxMHwJH
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Mashup Score: 7Patient-reported improvements in paroxysmal nocturnal hemoglobinuria treated with iptacopan from 2 phase 3 studies - 4 day(s) ago
Key PointsPatients with PNH treated with iptacopan experience meaningful improvement in fatigue and quality of life.In complement inhibitor–experienced pat
Source: ashpublications.orgCategories: General Medicine NewsTweet-
In complement inhibitor–experienced patients, improvements in fatigue and quality of life are associated with increased Hb levels. https://t.co/aVu7Yh3l7v #clinicaltrialsandobservations https://t.co/K16fviOzls
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Mashup Score: 6
Key PointsA partnership with the Dominican Republic built local capacity and established a SC TCD screening program for primary stroke prevention.Hydroxyur
Source: ashpublications.orgCategories: General Medicine NewsTweet-
A partnership with the Dominican Republic built local capacity and established a SC TCD screening program for primary stroke prevention. https://t.co/QsJw2ojwvv #clinicaltrialsandobservations #globaladvances #redcellsironerythropoiesis https://t.co/kUoWGtP33I
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Mashup Score: 70Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia - 5 day(s) ago
Key PointsCH mutations persist through AML-directed therapy, suggesting their presence in preleukemic cells is not eliminated by chemotherapy.DNMT3A, TET2,
Source: ashpublications.orgCategories: General Medicine NewsTweet-
DNMT3A, TET2, and ASXL1 mutations differentially shape the subsequent evolutionary trajectories of AML from diagnosis through relapse. https://t.co/MKxqP7Qhdg #myeloidneoplasia https://t.co/NUOq1TTWCQ
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Mashup Score: 46Audit of B-cell cancer genes - 5 day(s) ago
Abstract. Comprehensive genetic analysis of tumors with exome or whole-genome sequencing has enabled the identification of the genes that are recurrently m
Source: ashpublications.orgCategories: General Medicine NewsTweet-
The gene lists for BL, FL, and DLBCL naturally contain significant overlap because many of the same genes are mutated in multiple B-cell neoplasms. https://t.co/V94XuB11B1 #lymphoidneoplasia https://t.co/WFGzwxlYJl
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Mashup Score: 15
Abstract. Dysregulated JAK/STAT signaling underlies the pathogenesis of myelofibrosis, a myeloproliferative neoplasm characterized by cytopenias, splenomeg
Source: ashpublications.orgCategories: General Medicine News, Onc News and JournalsTweet-
Selecting the appropriate JAKi, including fedratinib, is dependent on certain patient and disease risk factors. https://t.co/oKMOveRFPk #myeloidneoplasia https://t.co/81G7mbnG1S
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Dapsone risk-benefit ratio as a second line for adult primary ITP should be carefully weighed when approved drugs are readily available. https://t.co/FVgKh8NNpT #plateletsandthrombopoiesis https://t.co/cyuD9CCQTh