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Mashup Score: 3Guadecitabine vs TC in relapsed/refractory AML after intensive chemotherapy: a randomized phase 3 ASTRAL-2 trial - 3 hour(s) ago
There was no clear survival benefit for guadecitabine over standard-of-care in patients with relapsed/refractory AML.Guadecitabine produced higher clinical
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Mashup Score: 7Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia - 1 day(s) ago
Pediatric MLLT10+ AML have poor prognosis and may benefit from targeted therapies.Patients with PICALM::MLLT10+ and X::MLLT10+ exhibit DNA hypermethylation
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Mashup Score: 22Flares of acute graft-versus-host disease: a Mount Sinai Acute GVHD International Consortium analysis - 3 day(s) ago
After initial clinical response, flares of acute GVHD are common and associated with higher NRM.MAGIC biomarkers at first CR/VGPR can predict GVHD flares.
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Mashup Score: 17Incidence and risk factors of pain crisis after hematopoietic cell transplantation for sickle cell disease - 3 day(s) ago
Recurrence of VOC requiring hospitalization or treatment occurs in 8.7% of patients after HCT with stable donor engraftment in SCD.GF, age at HCT, prior hi
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Mashup Score: 40Steroid tapering after GVHD Rx: not too fast, not too slow - 4 day(s) ago
In this issue of Blood Advances, Akahoshi et al1 provided evidence that higher serum concentrations of suppression of tumorigenicity 2 (ST2) and regenerati
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Mashup Score: 1Better eat! - 4 day(s) ago
In this issue of Blood Advances, Lineburg et al describe the interplay between graft-versus-host disease (GVHD), hematopoietic stem cell (HSC) engraftment,
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Mashup Score: 9Survival for the fittest: guadecitabine in rel/ref AML - 4 day(s) ago
Relapsed or refractory acute myeloid leukemia (AML) has an extremely poor prognosis because of intrinsic chemotherapy resistance and high rates of relapse,
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Mashup Score: 55Maintenance therapy for early loss of B-cell aplasia after anti-CD19 CAR T-cell therapy - 5 day(s) ago
TO THE EDITOR:
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Mashup Score: 40Real-world applicability of the International Metabolic Prognostic Index in DLBCL: a validation cohort study - 5 day(s) ago
TO THE EDITOR:
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Mashup Score: 54Maintenance therapy for early loss of B-cell aplasia after anti-CD19 CAR T-cell therapy - 5 day(s) ago
TO THE EDITOR:
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Guadecitabine produced higher clinical response rates, with potential survival benefit in several prespecified subgroups. https://t.co/HIsprZQRMu #clinicaltrialsandobservations #myeloidneoplasia https://t.co/CEjR3dsj0T