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Mashup Score: 11Is estimated exposure an accurate surrogate for measured fludarabine levels in patients with CAR T-cell therapy? - 20 hour(s) ago
TO THE EDITOR:
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Mashup Score: 1Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module - 2 day(s) ago
Conformationally insensitive nanobodies activate VWF binding of platelets by disrupting its NAIM.Conformationally sensitive nanobodies inhibit VWF binding
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Mashup Score: 14
Blood Advances | 8 | 9 | May 2024
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Mashup Score: 101Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module - 2 day(s) ago
Conformationally insensitive nanobodies activate VWF binding of platelets by disrupting its NAIM.Conformationally sensitive nanobodies inhibit VWF binding
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Mashup Score: 27Monocytes in leukapheresis products affect the outcome of CD19–targeted CAR T-cell therapy in patients with lymphoma - 3 day(s) ago
Combining circulating absolute monocyte count and a 4-gene monocyte signature at leukapheresis predicts PFS of LBCL receiving CAR T cells.Monocytes depleti
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Mashup Score: 8Identifying an optimal fludarabine exposure for improved outcomes after axi-cel therapy for aggressive B-cell non-Hodgkin lymphoma - 5 day(s) ago
Key Points. Previous studies showed that fludarabine PK exposure is associated with key outcomes in pediatric patients after tisagenlecleucel.In adults receivin
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Mashup Score: 17A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice - 5 day(s) ago
RLYB331 is a human antibody that increases hepcidin, reduces iron overload, and ameliorates ineffective erythropoiesis in β-thalassemiaCombination with RAP
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Mashup Score: 26Sinonasal DLBCL: molecular profiling identifies subtypes with distinctive prognosis and targetable genetic features - 6 day(s) ago
ABC and GCB subtype sinonasal DLBCL are geno- and phenotypically distinct entities, exhibiting a contrasting disease course and prognosis.ABC subtype sinon
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Mashup Score: 0A molecular circuit linking the BCR to the NAD biosynthetic enzyme NAMPT is an actionable target in Richter syndrome - 6 day(s) ago
BCR cross-linking activates a positive feedback loop including NAMPT and sirtuins and converging on AKT activation.PI3Kγ/δ and NAMPT inhibitors synergize i
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Mashup Score: 8Tyrosine kinase inhibitor resistance in de novo BCR::ABL1–positive BCP-ALL beyond kinase domain mutations - 6 day(s) ago
Imatinib resistance at diagnosis was higher in cells of patients who relapsed vs those in remission after imatinib and chemotherapy.Low levels of BCR::ABL1
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Is estimated exposure an accurate surrogate for measured fludarabine levels in patients with CAR T-cell therapy? https://t.co/6x0ACKeVzD #commentary #immunobiologyandimmunotherapy #lymphoidneoplasia https://t.co/tR1i3g46pi