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Mashup Score: 4Modulating the Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity - 20 day(s) ago
Abstract. Although mesenchymal stromal cell (MSC) based therapies hold promise in regenerative medicine, their clinical application remains challenging due
Source: academic.oup.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 48Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence - 21 day(s) ago
Cappabianca and colleagues manufactured virus-free CAR T cells at scale with CRISPR/Cas9 and ‘metabolically primed’ by attenuating activation in low glucose/glutamine media with expansion in high glucose/glutamine media. Priming made CAR T-cells with increased stem cell memory properties, including enriched central memory phenotypes in vivo while lysing solid tumors.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma - 27 day(s) ago
Hoang et al. shows that DNA methyltransferase 3A (DNMT3A) regulates cellular energy production in mitochondria and contributes to the resistance of mantle cell lymphoma to ibrutinib, an inhibitor of Bruton tyrosine kinase. Targeting DNMT3A with low-dose decitabine is a potential therapeutic strategy to overcome ibrutinib resistance.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Home | Casting For Kids - 28 day(s) ago
Casting For Kids is a catch and release fishing tournament fundraiser in Madison, WI that benefits the American Family Children’s Hospital / UW Carbone Center.
Source: www.casting4kids.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9
Background Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have shown that cellular therapies like human mesenchymal stromal cells (MSCs), or monocytes/macrophages educated ex-vivo with extracellular vesicles (EVs) from MSCs were effective in a lethal H-ARS mouse model. However, given the complexity of generating cellular therapies and the potential risks of using allogeneic products, development of an “off-the-shelf” cell-free alternative like EVs may have utility in conditions like H-ARS that require rapid deployment of available therapeutics. The purpose of this study was to determine the feasibility of producing MSC-derived EVs at large scale using a bioreactor and assess critical quality control attributes like identity, sterility, and potency in educating monocytes and promoting survival in a lethal H-ARS mouse model. Methods EVs w
Source: stemcellres.biomedcentral.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0President’s Cancer Panel Report Highlights Opportunities to Accelerate Progress Toward the National Cancer Plan - The ASCO Post - 2 month(s) ago
In its report, the Panel urges continued and new focus in five priority areas to ensure that every person in the United States has equitable access to the best possible resources and care for cancer risk reduction, detection, treatment, and survivorship. Increase investment in biomedical research: Public investments alone are not enough to accelerate progress in cancer research. The private sector must increase its funding for cancer research taking place at academic and other publicly funded institutions.
Source: ascopost.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 48Engineering new CAR T-cell treatments for pediatric leukemia - 2 month(s) ago
Dr. Becky Richards is studying ways to treat acute myeloid leukemia using immunotherapy, which harnesses a patient’s own immune system to fight their cancer.
Source: www.uwhealth.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function - 2 month(s) ago
Cellular therapies are currently employed to treat a variety of disease processes. For T cell–based therapies, success often relies on the metabolic f…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 34Pediatric Stem Cell Transplant and Cellular Therapy Physician - Madison, Wisconsin, United States - 2 month(s) ago
Job Summary: The Division of Hematology, Oncology, and Bone Marrow Transplant within the Department of Pediatrics at the University of Wisconsin School of Medicine and Public Health is recruiting a Pediatric Stem Cell Transplant and Cellular Therapy (SCTCT) Physician. We are looking for candidates with a track record of clinical excellence and academic contributions as demonstrated through training and/or practice experience in caring for patients undergoing stem cell transplantation and other cellular therapies like CAR T therapy. Special consideration will be made for candidates interested in neuroblastoma. Leadership opportunities within our stem cell transplant program are available, commensurate with experience….
Source: jobs.wisc.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 20Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity - 3 month(s) ago
Zoine et al. engineer a peptide-scFv antigen recognition domain as part of a bispecific chimeric antigen receptor (CAR). They utilize a systematic approach to design and test combinations by performing structural and functional evaluation. Their bispecific CAR demonstrates antitumor activity in vitro and in vivo while maintaining dual-antigen specificity.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
Congrats to Connie Chamberlain @wiscorthopedics Peng Jiang @CLE_State on showing @StemCellsJournl that #MSC #exosomes can facilitate repair of ligaments in an MCL injury model in part through altered microRNA levels. Great collaborative effort! https://t.co/3Su4tZUSiy