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Mashup Score: 3
Fang et al. discovered that male and female mice display different empathic behaviors in response to others’ pain. Specifically, males engage in self-grooming, whereas females demonstrate social approaching. Processing information about others’ pain involves distinct neural circuits for each sex. Importantly, these circuits inherently differ in gene expression patterns.
Source: www.cell.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 4
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit rapid and enduring cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 36Modulation of host immunity by sensory neurons - 11 hour(s) ago
Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary research field.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 38Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis - 11 hour(s) ago
Yu et al. showcase itaconate, an endogenous metabolite, as a potential anti-obesity agent. Their study reveals itaconate’s ability to reduce weight gain, improve glucose tolerance, and enhance energy expenditure in high-fat-diet-fed mice. This study highlights itaconate as a promising candidate for anti-obesity therapy, offering new insights into metabolic regulation.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 26Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint - 13 hour(s) ago
Mulè et al. provide a framework for integrating human population and single-cell variations to study vaccine responses with and without the adjuvant AS03. They uncover AS03-specific B cell survival and innate-sensing signatures 1 day after vaccination. Furthermore, some AS03-induced response cell states are already present at baseline in
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 7HGG Advances | Cell Press - 13 hour(s) ago
HGG Advances, an open access journal publishing across the complete spectrum of human genetics and genomics research, launched in 2020. We have since made exciting progress and were awarded our first Impact Factor of 4.4 in June 2023. Our mission is to build the human genetics and genomics knowledge base and provide a home for human genetics and genomics research characterized by high standards of scientific rigor, validity, and reproducibility. “At HGG Advances, we aim to publish high quality scientific
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Cell wall-mediated root development is targeted by a soil-borne bacterial pathogen to promote infection - 14 hour(s) ago
Yu et al. show that Ralstonia, a soil-borne bacterial pathogen, secretes an effector protein inside plant cells to disrupt cellulose biosynthesis and promote the formation of lateral roots, providing additional entry points for invasion of host plants. This shows that Ralstonia manipulates root development in order to promote infection.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 109
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit rapid and enduring cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 21A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification - 15 hour(s) ago
Multilayered gene regulation orchestrates cell-type-specific cytokine expression. Liu et al. examine the impact of chromatin loop formation on the expression of IFN-γ and IL-22, which are cytokine loci closely located in the genome, and identify an inducible topologically associating domain required for proper IFN-γ production in Th1 cells. Deleting a CTCF-binding site within this domain leads to lineage-specific cytokine dysregulation and increased susceptibility to pathogens.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 4
Language models have contributed to breakthroughs in interdisciplinary research, such as protein design and molecular dynamics understanding. In this study, we reveal that beyond language, representations of other entities, such as human behaviors, that are mappable to learnable sequences can be learned by language models. One compelling example is the real-world delivery route optimization problem. We here propose a novel approach based on the language model to optimize delivery routes on the basis of drivers’ historical experiences.
Source: www.cell.comCategories: General Medicine News, General NewsTweet
Sexually dimorphic control of affective state processing and empathic behaviors (in mice) https://t.co/DGpKElujAg