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Mashup Score: 1Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study - 7 hour(s) ago
AbstractBackground:. Ultrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County.Methods:. Within the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence. Multivariable Cox proportional hazards regression models were used to estimate the effect of UFP exposure on lung cancer incidence. Subgroup analyses by demographics, histology and smoking status were conducted.Results:. Airport-related UFP exposure was not associated with lung cancer risk [per one IGR HR, 1.01; 95% confidence interval (CI), 0.97–1.05] overall and across race/ethnicity. A suggestive positive association was observed between a o
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Mashup Score: 6A Novel Approach for Conducting a Catchment Area Analysis of Breast Cancer by Age and Stage for a Community Cancer Center - 1 day(s) ago
AbstractBackground:. The U.S. Preventive Services Task Force recently issued an updated draft recommendation statement to initiate breast cancer screening at age 40, reflecting well-documented disparities in breast cancer–related mortality that disproportionately impact younger Black women. This study applied a novel approach to identify hotspots of breast cancer diagnosed before age 50 and/or at an advanced stage to improve breast cancer detection within these communities.Methods:. Cancer registry data for 3,497 women with invasive breast cancer diagnosed or treated between 2012 and 2020 at the Helen F. Graham Cancer Center and Research Institute (HFGCCRI) and who resided in the HFGCCRI catchment area, defined as New Castle County, Delaware, were geocoded and analyzed with spatial intensity. Standardized incidence ratios stratified by age and race were calculated for each hotspot.Results:. Four hotspots were identified, two for breast cancer diagnosed before age 50, one for advanced b
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Mashup Score: 1Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women - 4 day(s) ago
AbstractBackground:. Distinguishing ovarian cancer from other gynecological malignancies is crucial for patient survival yet hindered by non-specific symptoms and limited understanding of ovarian cancer pathogenesis. Accumulating evidence suggests a link between ovarian cancer and deregulated lipid metabolism. Most studies have small sample sizes, especially for early-stage cases, and lack racial/ethnic diversity, necessitating more inclusive research for improved ovarian cancer diagnosis and prevention.Methods:. Here, we profiled the serum lipidome of 208 ovarian cancer, including 93 early-stage patients with ovarian cancer and 117 nonovarian cancer (other gynecological malignancies) patients of Korean descent. Serum samples were analyzed with a high-coverage liquid chromatography high-resolution mass spectrometry platform, and lipidome alterations were investigated via statistical and machine learning (ML) approaches.Results:. We found that lipidome alterations unique to ovarian canc
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Mashup Score: 0OnlineFirst - 5 day(s) ago
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Mashup Score: 0Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status - 6 day(s) ago
AbstractBackground:. OncotypeDx is a prognostic and predictive genomic assay used in early-stage hormone receptor–positive, HER2− (HR+/HER2−) breast cancer. It is used to inform adjuvant chemotherapy decisions, but not all eligible women receive testing. We aimed to assess variation in testing by demographics and geography, and to determine whether testing was associated with chemotherapy.Methods:. For 1,615 women in the Carolina Breast Cancer Study with HR+/HER2−, Stage I–II tumors, we estimated prevalence differences (PD) and 95% confidence intervals (CI) for receipt of OncotypeDx genomic testing in association with and sociodemographic characteristics. We assessed associations between testing and chemotherapy receipt overall and by race. Finally, we calculated the proportion of eligible women receiving OncotypeDx by county-level rurality, census tract-level socioeconomic status, and Area Health Education Center regions.Results:. 38% (N = 609) of potentially eligible women were teste
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Mashup Score: 6A Novel Approach for Conducting a Catchment Area Analysis of Breast Cancer by Age and Stage for a Community Cancer Center - 7 day(s) ago
AbstractBackground:. The U.S. Preventive Services Task Force recently issued an updated draft recommendation statement to initiate breast cancer screening at age 40, reflecting well-documented disparities in breast cancer–related mortality that disproportionately impact younger Black women. This study applied a novel approach to identify hotspots of breast cancer diagnosed before age 50 and/or at an advanced stage to improve breast cancer detection within these communities.Methods:. Cancer registry data for 3,497 women with invasive breast cancer diagnosed or treated between 2012 and 2020 at the Helen F. Graham Cancer Center and Research Institute (HFGCCRI) and who resided in the HFGCCRI catchment area, defined as New Castle County, Delaware, were geocoded and analyzed with spatial intensity. Standardized incidence ratios stratified by age and race were calculated for each hotspot.Results:. Four hotspots were identified, two for breast cancer diagnosed before age 50, one for advanced b
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Mashup Score: 0Reviewer Training Program | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research - 11 day(s) ago
Reviewer Training Program | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research .aacrcontent h2{ margin-top: 34px; margin-bottom: 16px; } .aacrcontent ul {list-style-image: url(‘/ImageLibrary/cebp/icons/cebp_bullet-9px.png’);} .aacrcontent ul li{margin-bottom: 12px;} .aacrcontent .mainbox{ display: flex; flex-direction: row; justify-content: space-around; align-items: stretch; align-content: flex-start; } .mainbox .box1{ width: 45%; margin: auto; padding:0; vertical-align: middle; } .mainbox .box1 ul { list-style-image: url(‘/ImageLibrary/cebp/icons/cebp-checkmark.png’); text-align: left; } .mainbox .box1 ul…
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Mashup Score: 0Volume 33 Issue 5 | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research - 13 day(s) ago
Cancer Epidemiology, Biomarkers & Prevention | 33 | 5 | May 2024
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Mashup Score: 0The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women - 13 day(s) ago
AbstractBackground:. Folate is the primary methyl donor and B vitamins are cofactors for one-carbon metabolism that maintain DNA integrity and epigenetic signatures implicated in carcinogenesis. Breast tissue is particularly susceptible to stimuli in early life. Only limited data are available on associations of one-carbon metabolism–related vitamin intake during youth and young adulthood with breast density, a strong risk factor for breast cancer.Methods:. Over 18 years in the DISC and DISC06 Follow-up Study, diets of 182 young women were assessed by three 24-hour recalls on five occasions at ages 8 to 18 years and once at 25 to 29 years. Multivariable-adjusted linear mixed-effects regression was used to examine associations of intakes of one-carbon metabolism-related vitamins with MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at ages 25 to 29 years.Results:. Folate intake in youth was inversely associated with %DBV (Ptrend = 0.006) and ADBV (
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Mashup Score: 1The Reach of Calls and Text Messages for Mailed FIT Outreach in the PROMPT Stepped-Wedge Colorectal Cancer Screening Trial - 14 day(s) ago
AbstractBackground:. Mailed fecal immunochemical test (FIT) outreach can improve colorectal cancer screening participation. We assessed the reach and effectiveness of adding notifications to mailed FIT programs.Methods:. We conducted secondary analyses of a stepped-wedge evaluation of an enhanced mailed FIT program (n = 15 clinics). Patients were stratified by prior FIT completion. Those with prior FIT were sent a text message (Group 1); those without were randomized 1:1 to receive a text message (Group 2) or live phone call (Group 3). All groups were sent automated phone call reminders. In stratified analysis, we measured reach and effectiveness (FIT completion within 6 months) and assessed patient-level associations using generalized estimating equations.Results:. Patients (n = 16,934; 83% Latino; 72% completed prior FIT) were reached most often by text messages (78%), followed by live phone calls (71%), then automated phone calls (56%). FIT completion was higher in patients with pri
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Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study. https://t.co/hVcSxBFmu9 https://t.co/EQSxQ9Ur11