The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.

Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.

High-frequency tactile vibration signals captured by Pacinian corpuscles are routed to the lateral cortex of the inferior colliculus (LCIC), where they converge with auditory inputs and mediate behavioral responses.

Selective pressure for biallelic inactivation varies widely across tumor suppressor genes and is a biomarker for therapeutic response, providing new insights into Knudson’s two-hit hypothesis.

Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.

YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby serving as a dual reader for both m5C and m6A modifications. Small molecules that target YTHDF2 reduce ATP synthesis and are therapeutic candidates for B cell malignancies, especially when combined with CAR-T therapy or bispecific engagers.

Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands and niche adipocytes, which in turn selectively induces apoptosis of hair follicle stem cells but not epidermal stem cells in the skin.