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Mashup Score: 9Home – Cell Symposia: Functional RNAs - 13 hour(s) ago
Cell Symposia: Functional RNAs
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Mashup Score: 25
Using single-nucleus RNA-seq coupled with activity-regulated genes, Guo et al. identify one galanin neuronal subtype in the preoptic area activated during recovery sleep and show cell-type-specific increases in Htr2a and P2ry14. RNAscope studies using identified marker genes reveal the anatomical location of this galanin subtype as the ventrolateral preoptic area.
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Mashup Score: 20Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer - 1 day(s) ago
Blawski et al. show that KMT2D is methylated by the lysine methyltransferase SMYD2 at K1330. SMYD2 loss attenuates PI3K inhibitor-induced KMT2D chromatin binding at estrogen-receptor (ER) loci and ER-dependent transcription. SMYD2 inhibition sensitizes cells, patient-derived organoids, and tumors to PI3K/AKT inhibition and endocrine therapy through KMT2D K1330 methylation.
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Mashup Score: 52
Rivard et al. report that a combination of density-based replisome enrichment and label-free quantitative mass spectrometry (iPOND2-DRIPPER) substantially increases both replication and repair factor yields and the dynamic range of protein quantification. Using this method, the authors identify notable ubiquitination and spatiotemporal changes in replication-fork-associated proteins following replication stress.
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Mashup Score: 2Development of segregation and integration of functional connectomes during the first 1,000 days - 1 day(s) ago
Li et al. report the maturational principles of network segregation and integration of the functional connectome during the first 1,000 days of human life. They also show the importance of early connectome remodeling for later neurocognitive outcomes and establish the associations with gene expression signatures of neurodevelopment and metabolism.
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Mashup Score: 16
Dhaliwal et al. used human pluripotent stem cell-derived neurons, neural precursors, and cortical organoids to show that hyperactivation of both mTORC1 and mTORC2 contributes to the PTEN mutant neural phenotypes. Their results provide insights into the molecular mechanisms that underlie PTEN-related neurodevelopmental disorders and highlight novel therapeutic targets.
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Mashup Score: 31
Cuhadar et al. find that the abundance of LGI1 at the presynaptic surface controls glutamatergic transmission. Synaptic surface LGI1 increases with neuronal activity but is reduced by patient-derived autoantibodies against LGI1. Results support the role of LGI1 in the control of synaptic transmission and its causal role in epilepsy.
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Mashup Score: 105Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing reprogramming - 2 day(s) ago
Martinez-Sarmiento et al. demonstrate that, during heterokaryon reprogramming, global chromatin decondensation and loss of repressive histone modifications occur at late stages after cell fusion. Activation of OCT4 precedes global chromatin decompaction and does not require the opening of its local genomic region. Conversely, NANOG activation occurs after OCT4 activation, and the NANOG locus undergoes opening prior to its transcriptional activation.
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Mashup Score: 1Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations - 2 day(s) ago
(Cell Reports 36, 109673; September 7, 2021)
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Mashup Score: 40
The insect gustatory receptors (Grs) are one of the largest families of ion channels in the animal kingdom. Frank et al. unveil the structure of a fructose-sensing Gr and provide insight into its function.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
We’re excited to hear @YiliangDing @JohnInnesCentre discuss #RNAstructure @CellSymposia #CSRNAs24, October 20–22, 2024, Beijing, China. For more information and to register visit: https://t.co/j9kiJTa1JZ https://t.co/iDc21TkZ1b