Zhang et al. determined human OAT1 structures in the apo state and bound to probenecid, adefovir, cefazolin, and PAH, revealing a planar ligand-binding mode. Distinctly, the OAT4-DHEAS structure displays a perpendicular ligand-binding mode.

Alcacer and Klaus et al. combine motion sensors and video data to automatically classify dyskinetic behaviors in a mouse model of L-DOPA-induced dyskinesia. Calcium imaging reveals that distinct dyskinesia-related behaviors are encoded by specific hyperactive D1- and D2-SPN ensembles, linking abnormal movements to structured striatal circuit activity.

Lacava et al. characterize a descending vestibulospinal pathway originating from the spinal vestibular nucleus that targets spinal segments controlling tail muscles in mice. Activation of this pathway increases tail rotation during challenging balancing task.

TBK1 is well established as a key regulator of antiviral immunity, while its role in antifungal defense remains elusive. Feng et al. reveal that upon Candida albicans stimulation, TBK1 translocates to the phagosome in an SRC-dependent manner, where it undergoes phosphorylation and forms a positive feedback loop with SRC, thereby amplifying antifungal immune responses.

Prasanphanich et al. demonstrate that granulysin-high decidual natural killer cells (dNKs) of rhesus macaques and humans share conserved signatures of antimicrobial defense and immunoregulation. Moreover, granulysin-high dNKs respond to inflammation and infection by increasing cytotoxic, cytokine, and inflammatory signatures, further defining GNLY-high dNKs as important immune effectors providing placental immunity.