• Mashup Score: 12

    Background Outcome measure choice and definition can determine the result of the study. We describe outcome measures and their definitions for cardiovascular studies in highly cited medical journals. Methods Cardiovascular phase III or IV randomised clinical trials (RCTs) or multicentre observational studies published in the New England Journal of Medicine , Lancet or Journal of the American Medical Association between 1 January 2013 and 6 June 2024 from Embase and Ovid Medline were included. Two independent reviewers selected the studies and extracted the primary and secondary outcome measures from each publication. Results 386 studies (83% RCTs; 17% observational) representing 10 699 147 participants were included. Studies investigated coronary heart disease (51%), cardiomyopathy/heart failure (22%), heart rhythm disease (15%), valvular heart disease (11%) and ‘other’ cardiovascular diseases (1%), with 45% investigating a device and 48% funded by industry. The most frequently reporte

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    • In our @Heart_BMJ systematic review of 386 CV studies in @NEJM @TheLancet @JAMA_current the most frequent primary outcome was a composite; the median number of secondary outcomes per study increased; & definitions for CV death, MI & stroke varied. https://t.co/fZYwoZlSO7

  • Mashup Score: 5

    Objectives We hypothesised that there is substantial variation in acute myocardial infarction (AMI) treatment across English hospitals, particularly for people hospitalised for non-ST-elevation myocardial infarction (NSTEMI) and with reduced kidney function. This study aimed to describe this variation at the hospital and the individual level to understand treatment variation and potential disparities in AMI management among people with reduced kidney function. Design Cross-sectional study. Setting Secondary care in England. Participants People hospitalised for AMI (ST-elevation myocardial infarction (STEMI) or NSTEMI) in English hospitals and captured in the Myocardial Ischaemia National Audit Project, 2014 to 2019. Kidney function was defined using estimated glomerular filtration rate (eGFR) derived from the serum creatinine recorded within 24 hours of AMI admission. Outcome measure The primary outcome was recorded invasive cardiac intervention (at least one of angiography, percutaneo

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    • More variation according to patient characteristics (🤔, #cardiovascular inequity); this time #heartattack management by #kidney function in English hospitals using Myocardial Ischaemia National Audit Project (#MINAP) data. @BMJ_Open @CardiacAudit https://t.co/9lptsG8xDM

  • Mashup Score: 2

    Hearing a patient’s story in their own words has changed our working culture, write Pietro Majno-Hurst and colleagues For the past four years we have been asking patients who are scheduled for major surgery to write and share a short biography with the healthcare team: “Introduce yourself as you want to be known by the people who will look after you. Tell us also what is important to you, and what is important that the staff knows to care for you as a person and not just as the bearer of your disease.” We didn’t expect such a positive response from patients and families. We initially discuss our project with patients when we see them in the clinic and then follow up shortly afterwards with a letter explaining it. On hearing our request, almost every patient eases back into their chair and thanks us for this opportunity. They often …

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    • 🤔, is collecting & reviewing patient biographies aspirational (& unrealistic) for the #NHS? https://t.co/zwQwoIREud