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Mashup Score: 13
Annals of Surgical Oncology – Data regarding the survival impact of converting frozen-section (FS):R1 pancreatic neck margins to permanent section (PS):R0 by additional resection (i.e.,…
Source: link.springer.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX - 21 day(s) ago
This cohort study uses data from an existing cohort of patients undergoing resection of pancreatic cancer to assess the overall survival of patients treated with neoadjuvant FOLFIRINOX after surgery for pancreatic ductal adenocarcinoma.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 15Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer - 2 month(s) ago
Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer
Source: hbsn.amegroups.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4
Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is associated with worse survival compared with either KRAS-alone or TP53-alone altered PDAC in 245 patients with metastatic disease treated at a tertiary referral cancer center, and validate…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
This👇🏽! And why it’s important to 🧐 distinct transcriptional networks invoked by cooperativity w KRAS etc in driving immune suppression (shameless 🔌: https://t.co/1YaXh2Ahjg) & metastatic proclivity (https://t.co/Kp8OOnulxa)! IMO must account for this in era of KRAS inhibitors https://t.co/WvitWUsmdf
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Mashup Score: 8
Single-nucleus and spatial, whole-transcriptome profiling of 43 pancreatic adenocarcinomas provides a refined molecular and cellular classification, highlighting a new neoadjuvant treatment-associated neural-like progenitor tumor cell state.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
@Aiims1742 @HenryFordHealth @HCCvPDAC @Daniel_Salas671 @NinaSteele17 @DelgiornoKathy @SearsRosie Interesting! Excited to read in depth. Congrats @Daniel_Salas671 @HCCvPDAC & HFPCC team! CC: @DrWilliamHwang & his recent @NatureGenet paper re role of NRP cell persistence following chemoRT https://t.co/Asydh5hEhr
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Mashup Score: 53Student Spotlight: Riyaan Datta '30 - Gulliver Prep - 3 month(s) ago
Riyaan Datta ‘30 is the reigning Florida State Elementary (K-5) Chess Champion.
Source: www.gulliverprep.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Help me Challenge Cancer! - 4 month(s) ago
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTeamOneFight
Source: dolphins.donordrive.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 24Multiomic Characterization Reveals a Distinct Molecular Landscape in Young-Onset Pancreatic Cancer - 4 month(s) ago
PURPOSE Using a real-world database with matched genomic-transcriptomic molecular data, we sought to characterize the distinct molecular correlates underlying clinical differences between patients with young-onset pancreatic cancer (YOPC; younger than 50 years) and patients with average-onset pancreatic cancer (AOPC; 70 years and older). METHODS We analyzed matched whole-transcriptome and DNA sequencing data from 2,430 patient samples (YOPC, n = 292; AOPC, n = 2,138) from the Caris Life Sciences database (Phoenix, AZ). Immune deconvolution was performed using the quanTIseq pipeline. Overall survival (OS) data were obtained from insurance claims (n = 4,928); Kaplan-Meier estimates were calculated for age- and molecularly defined cohorts. Significance was determined as FDR-corrected P values (Q) < .05. RESULTS Patients with YOPC had higher proportions of mismatch repair–deficient/microsatellite instability-high, BRCA2-mutant, and PALB2-mutant tumors compared with patients with AOPC, but
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Help me Challenge Cancer! - 4 month(s) ago
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTeamOneFight
Source: dolphins.donordrive.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Help me Challenge Cancer! - 4 month(s) ago
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTeamOneFight
Source: dolphins.donordrive.comCategories: General Medicine News, Hem/OncsTweet
Agreed! We published data with similar conclusions from the #CentralPancreasConsortium 7-center dataset a couple yrs ago @AnnSurgOncol👉🏽https://t.co/6N62mz3xET @SylvesterCancer @FrancisIgorMac1 @NbmerchantMD @SyedAAhmad5 @skmaithel @DavidKoobyMD @GregWilson152 @kimhjUNC et al https://t.co/EgZpu5GP3O