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Mashup Score: 20
Both p-tau217 assays had excellent diagnostic performance for AD. Our study supports the future clinical use of commercially-available assays for p-tau217.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 20
Both p-tau217 assays had excellent diagnostic performance for AD. Our study supports the future clinical use of commercially-available assays for p-tau217.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 10A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studies - 2 day(s) ago
IGG is linked to improved prognosis and pCR in early-stage TNBC. The integration of IGG alongside tumor and nodal staging holds promise as an approach to identify patients benefitting from intensified or de-intensified treatments.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
Editor pick from April issue @BenedettaConte5 @prat_aleix @fara_bm & coll Identified a 14-gene immunoglobulin B-cell signature linked to improved prognosis and pathological complete response in patients with early-stage triple-negative breast cancer Read https://t.co/c0A6tK9n8e https://t.co/oIqxxSMkbE
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Mashup Score: 0Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease - 5 day(s) ago
LRP-1 mediates the adverse effect of NAFLD on peripheral Aβ clearance, thereby contributing to cerebral Aβ accumulation and cognitive impairment in NAFLD.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment - 7 day(s) ago
Fingertip pulse oximeters have variable performance, frequently not meeting regulatory requirements for clinical use, and occasionally contradicting claims made by manufacturers. Most devices showed a trend toward worse performance in participants with darker skin pigment. Regulatory standards do not adequately account for the impact of skin pigmentation on device performance. We recommend that the pFP and other non-standardised subjective skin colour scales should no longer be used for defining diversity of skin pigmentation.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment - 8 day(s) ago
Fingertip pulse oximeters have variable performance, frequently not meeting regulatory requirements for clinical use, and occasionally contradicting claims made by manufacturers. Most devices showed a trend toward worse performance in participants with darker skin pigment. Regulatory standards do not adequately account for the impact of skin pigmentation on device performance. We recommend that the pFP and other non-standardised subjective skin colour scales should no longer be used for defining diversity of skin pigmentation.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohort - 9 day(s) ago
This study confirms that FGF14 GAA expansions are a frequent cause of DBN syndromes. It provides preliminary evidence that (GAA)200-249 alleles might be pathogenic. Finally, it provides large real-world and preliminary piloting placebo-controlled evidence for the efficacy of 4-aminopyridine in GAA-FGF14 disease.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohort - 10 day(s) ago
This study confirms that FGF14 GAA expansions are a frequent cause of DBN syndromes. It provides preliminary evidence that (GAA)200-249 alleles might be pathogenic. Finally, it provides large real-world and preliminary piloting placebo-controlled evidence for the efficacy of 4-aminopyridine in GAA-FGF14 disease.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 9Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: leveraging proteomics and machine learning for biomarker discovery - 14 day(s) ago
Here, we leveraged the natural shed of endometrial tumours to potentially develop an innovative approach to endometrial cancer detection. We show proof of principle that endometrial cancers secrete unique protein signatures that can enable cancer detection via cervico-vaginal fluid assays. Confirmation in a larger independent cohort is warranted.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Implantation of a double allogeneic human engineered tissue graft on damaged heart: insights from the PERISCOPE phase I clinical trial - 16 day(s) ago
In summary, the PeriCord graft has exhibited a safe profile and notable immunomodulatory properties. Nevertheless, further research is required to fully unlock its potential as a platform for managing inflammatory-related pathologies.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
Editor pick from April issue @JosephTherr @NicholasAshton @pedrorosaneto @andrealessa & coll Compared the performance of two commercially available plasma p-tau217 assays in 294 individuals with #Alzheimer's disease. Read https://t.co/FqC7XDlJTB https://t.co/3z64tKFbDB