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Mashup Score: 5Clinical and Immunologic Features of Germline Pathogenic Variant–Positive Patients with Melanoma - 2 month(s) ago
AbstractPurpose:. Malignant melanoma represents the most lethal skin cancer with germline predispositions thought to comprise 10% to 15% of all melanoma cases. No studies to date examine the immunologic features that may differentiate survival differences between germline pathogenic variant (gPV)–positive patients with melanoma from gPV-negative patients with melanoma.Experimental Design:. Adult patients with melanoma and clinical characteristics suggesting hereditary predisposition to cancer were prospectively recruited to undergo germline testing and flow cytometric analysis of peripheral immune suppressor cells.Results:. In this cohort, gPV-positive patients (n = 72) had a significantly improved melanoma-specific survival (MSS) compared with gPV-negative patients (n = 411; HRadj, 0.32; 95% CI, 0.13–0.82; P = 0.01). These survival improvements among gPV-positive patients were most apparent among cutaneous melanoma subtypes (HRadj, 0.12; 95% CI, 0.016–0.86; P = 0.03) and numerically i
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 47Germline Cancer Susceptibility in Individuals with Melanoma - 2 month(s) ago
Inherited melanoma is not rare: approximately 1 in 7 individuals with melanoma harbored clinically relevant hereditable cancer susceptibility in a prospective cross-sectional study, with 3 validation cohorts supporting 10-16% incidence. We recommend obtaining family history inclusive of non-cutaneous cancers and considering genetics referral for ≥2 melanomas/cancers to increase diagnostic yield.
Source: www.jaad.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 52The Immune Related Adverse Events (irAE) Consortium - GHLF.org - 3 month(s) ago
Immunotherapy is an emerging treatment that gives hope to patients facing different types of cancer. It stimulates the body’s immune system to fight cancer cell
Source: GHLF.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 48The Immune Related Adverse Events (irAE) Consortium - GHLF.org - 3 month(s) ago
Immunotherapy is an emerging treatment that gives hope to patients facing different types of cancer. It stimulates the body’s immune system to fight cancer cell
Source: GHLF.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4
Thieme E-Books & E-Journals
Source: www.thieme-connect.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3
Next Generation Dx Summit, August 21-23, 2023, Washington, D.C.
Source: www.nextgenerationdx.comCategories: Latest Headlines, Oncologists1Tweet
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Mashup Score: 1Advances in Cancer Immunotherapy Regional Education Programs - 11 month(s) ago
The SITC Advances in Cancer Immunotherapy (ACI) programs are CE- and MOC-accredited programs presented by local authorities in tumor immunology and cancer immunotherapy and are free for healthcare professionals, students and patient advocates.
Source: www.sitcancer.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Advances in Cancer Immunotherapy: A Focus on Toxicity Management – Part 2 | Tuesday, June 27 | Virtual - 11 month(s) ago
Join SITC and a panel of experts for an afternoon of in-depth education on all aspects of toxicity management. Part 2 will cover etiology and management strategies for hepatic, GI/diarrhea/colitis, renal/nephritis, neurologic, pancreatic and ocular toxicities. Free for healthcare professionals, students, patients and patient advocates.
Source: www.sitcancer.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Clinical Trials | Melanoma Research Foundation - 11 month(s) ago
Learn about clinical trials, ongoing trials for melanoma patients, and how you can participate or find a trial near you.
Source: Melanoma Research FoundationCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 17
In this study, Bhardwaj et al. highlight the mechanistic link between elevated body mass index and breast epithelial cell DNA damage in individuals carrying BRCA mutations.
Source: NatureCategories: Latest Headlines, Oncologists1Tweet
Also: Clinical and Immunologic Features of Germline Pathogenic Variant–Positive Patients with Melanoma @CCR_AACR Germline positive melanomas: ➡️improved melanoma-specific survival ➡️lower circulating PMN–MDSC ➡️upregulated inflammatory signature https://t.co/IqwNgcACOL