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Mashup Score: 1How to Define and Manage Low-Risk Drug Allergy Labels - 3 hour(s) ago
Risk stratification in drug allergy implies that specific risk categories (eg, low, moderate, and high) classify historical drug hypersensitivity reactions. These risk categories can be based on reaction phenotypic characteristics, the timing of the reaction and evaluation, the required reaction management, and individual characteristics. Although a multitude of frameworks have been described in the literature, particularly for penicillin allergy labels, there has yet to be a global consensus, and approaches continue to vary between allergy centers.
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Mashup Score: 9
Biologic modifiers targeting type 2 (T2) airway inflammation are effective in reducing asthma exacerbation. However, real-world and comparative effectiveness studies remain limited.
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Mashup Score: 16
The prevalence of peanut allergy is about 2% and mostly lifelong. Studies of oral immunotherapy (OIT) with peanut (the daily oral intake of an initially low and then increasing dose of peanut) often show problematic side effects, but there are indications of better safety and effect in younger children compared with older children and adults.
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Mashup Score: 4
Our resource for drug allergy evaluation and management has been updated! Read summaries of the Editors’ choices for Practice Changers, the fou r most practical Original Articles published in JACI: In Practice each month How JACI: In Practice Promotes Research for Authors and Readers. Learn more. JACI: In Practice, in conjunction with the AAAAI New Allergist/Immunologist Assembly offers one-hour live CME-eligible webinars discussing two recently published JACI: In Practice articles. Learn how to participat
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Mashup Score: 11Asthma COPD Overlap - 13 day(s) ago
A 51-year-old man with a past medical history of chronic obstructive pulmonary disease (COPD) diagnosed 3 years ago (45 pack-years of cigarettes, quit 2 y ago) on 2 L/min supplemental oxygen with exertion presents to clinic for initial evaluation.
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Mashup Score: 5
Vocal cord dysfunction (VCD) is a cause of acute and/or chronic respiratory symptoms. Vocal cord dysfunction, also called inducible laryngeal obstruction and paradoxical vocal fold movement, is the functional closure of vocal cords during inspiration diagnosed by direct visualization by rhinolaryngoscopy (RLG) when the patient is symptomatic, typically induced by bronchoprovocation challenges including methacholine inhalation or exercise. Vocal cord dysfunction is a common functional disorder that is often underrecognized and misdiagnosed as asthma.
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Mashup Score: 6Severity of eczema at patch site during epicutaneous immunotherapy may predict subsequent response to oral immunotherapy - 15 day(s) ago
Peanut epicutaneous immunotherapy (EPIT) consisting in the daily delivery of 250 μg of peanut protein through the skin using a patch device with a condensation chamber has been shown to increase the reactivity thresholds of children with allergy while on therapy (desensitization).1-5 Its main advantage over other immunotherapy routes is that it is generally well-tolerated. Most patients will experience mild local reactions at the patch application sites (Figure 1). These include IgE-mediated urticarial lesions, which usually improve in a matter of weeks, as local skin mast cells are progressively desensitized.
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Mashup Score: 0Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers - 18 day(s) ago
Recurrent preschool wheezers represent approximately 10% of children under 5 years of age.1 Among them, those who report frequent exacerbations (ie, 3 or more per year), mainly due to viral and/or bacterial infections, have an increased risk of persistent asthma and poor lung function throughout life.1,2 The risk of exacerbation has been previously associated with several clinical and/or biological parameters, including those of bronchial remodeling. The latter corresponds to a poorly reversible structural abnormality of the bronchial tissue (ie, altered epithelial integrity, increased mass of mucus gland and/or bronchial smooth muscle [BSM], increased density of blood vessels, and an increased collagen deposition leading to reticular basement membrane [RBM] thickening and increased submucosal fibrosis).
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Mashup Score: 10Contact Leukoderma Following Allergic Contact Dermatitis to a Smartwatch: A Consequence of Nickel Allergy - 19 day(s) ago
We present an original case of leukoderma appearing after nickel-induced allergic contact dermatitis.
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Mashup Score: 5Efficacy of EDS-FLU for Chronic Rhinosinusitis: Two Randomized Controlled Trials (ReOpen1 and ReOpen2) - 20 day(s) ago
Chronic rhinosinusitis (CRS) is a prevalent inflammatory disease. No medications are Food and Drug Administration–approved for the most common form, CRS without nasal polyps (also called “chronic sinusitis”). Novel biomechanics of the exhalation delivery system deliver fluticasone (EDS-FLU; XHANCE) to sinonasal areas above the inferior turbinate, especially sinus drainage pathways not reached by standard-delivery nasal sprays.
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