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Mashup Score: 55A message to our participants: unfounded claims in The Guardian - 1 month(s) ago
This is a message for our participants about a highly misleading and irresponsible article that has been published in The Guardian, and claims that a far-right network has had access to UK Biobank data.
Source: www.ukbiobank.ac.ukCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 4
The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.
Source: www.pgscatalog.orgCategories: General Medicine News, CardiologistsTweet-
RT @PGSCatalog: Now available in the PGS Catalog: https://t.co/aHeJZQVDbG thanks to @jpirruccello et al for submitting! Submit your score…
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Mashup Score: 0Pelosi Statement in Opposition to California Senate Bill 1047 | Representative Nancy Pelosi - 3 month(s) ago
San Francisco – Speaker Emerita Nancy Pelosi issued this statement in opposition to California Senate Bill 1047:
Source: pelosi.house.govCategories: General Medicine News, CardiologistsTweet-
@Scott_Wiener And Speaker Emerita Pelosi @SpeakerPelosi https://t.co/UzFd5oa5zH
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Mashup Score: 14The AORTA Gene score for detection and risk stratification of ascending aortic dilation - 3 month(s) ago
AbstractBackground and Aims. This study assessed whether a model incorporating clinical features and a polygenic score for ascending aortic diameter would
Source: academic.oup.comCategories: General Medicine News, CardiologistsTweet-
@shaan_khurshid @patrick_ellinor @ShinoKany @skoyamamd @EmeliaBenjamin @MarkELindsay @AllofUsResearch @uk_biobank Manuscript URL: https://t.co/t2jkL1aJZI
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Mashup Score: 0Cardiovascular magnetic resonance in an adult human population: serial observations from the multi-ethnic study of atherosclerosis - 3 month(s) ago
The Multi-Ethnic Study of Atherosclerosis (MESA) is the first large-scale multi-ethnic population study in the U.S. to use advanced cardiovascular magnetic resonance (CMR) imaging. MESA participants were free of cardiovascular disease at baseline between …
Source: www.ncbi.nlm.nih.govCategories: General Medicine News, CardiologistsTweet-
Context for this work: groups have predict cardiac aging with heart measurements; radiomic markers; and deep learning models before: https://t.co/ymYHXmvBjg https://t.co/cJI4fkDfxI https://t.co/SC8xfz3JL1 https://t.co/2rI7emhle8
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Mashup Score: 14The AORTA Gene score for detection and risk stratification of ascending aortic dilation - 3 month(s) ago
AbstractBackground and Aims. This study assessed whether a model incorporating clinical features and a polygenic score for ascending aortic diameter would
Source: academic.oup.comCategories: General Medicine News, CardiologistsTweet-
@shaan_khurshid @patrick_ellinor @ShinoKany @skoyamamd @EmeliaBenjamin @MarkELindsay @AllofUsResearch @uk_biobank Manuscript URL: https://t.co/t2jkL1aJZI
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Mashup Score: 14
Miscellaneous genomics tools and data structures. Contribute to carbocation/genomisc development by creating an account on GitHub.
Source: github.comCategories: General Medicine News, CardiologistsTweet-
The R program to implement this is located at https://t.co/5aQVYjjc2D and the polygenic score weights have been submitted to the @PGSCatalog , with the goal of making this as easy as possible to implement in additional cohorts.
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Mashup Score: 18Population Performance and Individual Agreement of Coronary Artery Disease Polygenic Risk Scores - 4 month(s) ago
Importance: Polygenic risk scores (PRSs) for coronary artery disease (CAD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease liability is a critical consideration for clinical implementation that remains uncharacterized. Objective: Characterize the reliability of CAD PRSs that perform equivalently at the population level at predicting individual-level risk. Design: Cross-sectional Study. Setting: All of Us Research Program (AOU), Penn Medicine Biobank (PMBB), and UCLA ATLAS Precision Health Biobank. Participants: Volunteers of diverse genetic backgrounds enrolled in AOU, PMBB, and UCLA with available electronic health record and genotyping data. Exposures: Polygenic risk for CAD from previously published PRSs and new PRSs developed separately from the testing cohorts. Main Outcomes and Measures: Sets of CAD PRSs that perform population prediction equivalently were identified by comparing calibration and discri
Source: www.medrxiv.orgCategories: General Medicine News, CardiologistsTweet-
Two interesting polygenic score papers on medrxiv this week: (1) from @sabramowitz_ / @MGLevin / @damrauer showing poor individual-level consistency of polygenic scores with kinda similar population performance https://t.co/7Ztnj1cfgV https://t.co/QdiSzt6Rvf
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Mashup Score: 4Instability of high polygenic risk classification and mitigation by integrative scoring - 4 month(s) ago
Polygenic risk scores (PRS) continue to improve with novel methods and expanding genome-wide association studies. Healthcare and third-party laboratories are increasingly deploying PRS reports to patients. Although new PRS show improving strengths of association with traits, it is unknown how the classification of high polygenic risk changes across individual PRS for the same trait. Here, we determined classification of high genetic risk from all cataloged PRS for three complex traits. While each PRS for each trait demonstrated generally consistent population-level strengths of associations, classification of individuals in the top 10% of each PRS distribution varied widely. Using the PRSMix framework, which incorporates information across several PRS to improve prediction, we generated sequential add-one-in (AOI) PRSMix_AOI scores based on order of publication. PRSMix_AOIₙ led to improved PRS performance and more consistent high-risk classification compared with the PRSₙ. The PRSMix
Source: www.medrxiv.orgCategories: General Medicine News, CardiologistsTweet-
(2) from Anika Misra / @AniruddhPatelMD / @pnatarajanmd seeking solutions to the PRS instability problem https://t.co/Ou5erY3JXg https://t.co/1Pale2IrhI
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Mashup Score: 18Population Performance and Individual Agreement of Coronary Artery Disease Polygenic Risk Scores - 4 month(s) ago
Importance: Polygenic risk scores (PRSs) for coronary artery disease (CAD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease liability is a critical consideration for clinical implementation that remains uncharacterized. Objective: Characterize the reliability of CAD PRSs that perform equivalently at the population level at predicting individual-level risk. Design: Cross-sectional Study. Setting: All of Us Research Program (AOU), Penn Medicine Biobank (PMBB), and UCLA ATLAS Precision Health Biobank. Participants: Volunteers of diverse genetic backgrounds enrolled in AOU, PMBB, and UCLA with available electronic health record and genotyping data. Exposures: Polygenic risk for CAD from previously published PRSs and new PRSs developed separately from the testing cohorts. Main Outcomes and Measures: Sets of CAD PRSs that perform population prediction equivalently were identified by comparing calibration and discri
Source: www.medrxiv.orgCategories: General Medicine News, CardiologistsTweet-
Two interesting polygenic score papers on medrxiv this week: (1) from @sabramowitz_ / @MGLevin / @damrauer showing poor individual-level consistency of polygenic scores with kinda similar population performance https://t.co/7Ztnj1cfgV https://t.co/QdiSzt6Rvf
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RT @uk_biobank: Read our statement about an article in @guardian about potential misuse of UK Biobank data: https://t.co/Sc2Kt8Wpsz