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Mashup Score: 13Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages - 3 hour(s) ago
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and generation of the three main epithelial cell lineages that make up the mammalian pancreas.
Source: www.cell.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 38Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition - 7 day(s) ago
Nature Biotechnology – A new mass spectrometry strategy combines the advantages of data-dependent and data-independent acquisition.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
A new mass spectrometry strategy combines the advantages of data-dependent and data-independent acquisition https://t.co/KVbAMquXiv https://t.co/mB7FDRHjTe
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Mashup Score: 8
Researchers describe TRACeR-I, a protein platform that can be used to engineer immune responses.
Source: www.news-medical.netCategories: General Medicine News, Future of MedicineTweet-
Breakthrough in antigen recognition: TRACeR-I enhances immune targeting #NBTintheNews via @NewsMedical https://t.co/SHQ57KZdiI
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Mashup Score: 77
Nature Biotechnology – An optical pooled screening method can correlate phenotypes and perturbations in any nucleated cell type.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
NIS-Seq enables cell-type-agnostic optical perturbation screening https://t.co/8pB5xIf7FA https://t.co/EWnHTjk0s7
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Mashup Score: 6
CRISPR-StAR, a novel screening technique, addresses the challenges of genetic screening in complex in vivo models by using internally controlled single-cell-level analysis. This method mitigates the noise of heterogeneous growth environments and bottlenecks, enabling robust identification of genetic dependencies in diverse tumour settings.
Source: crisprmedicinenews.comCategories: General Medicine News, Future of MedicineTweet-
@IMBA_Vienna CRISPR-StAR enhances in vivo genetic screening precision #NBTintheNews https://t.co/WFsqaUK02g
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Mashup Score: 7AI Powers Breakthroughs in Gene Therapy - 8 day(s) ago
AI techniques are revolutionizing gene therapy delivery for lung diseases, optimizing lipid nanoparticles to enhance mRNA transport and therapeutic efficacy.
Source: www.azorobotics.comCategories: General Medicine News, Future of MedicineTweet-
@MITChemE @kochinstitute @MITdeptofBE @BostonChildrens @IowaMed @MIT_IMES @JacobWitten1 @MananRajith AI powers breakthroughs in gene therapy #NBTintheNews via @AZoRobotics https://t.co/uwuRWxKeui
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Mashup Score: 12
Using AI, Insilico took only 12 months from initiating the project to nominating the molecule for preclinical trials, instead of several years.
Source: www.scmp.comCategories: General Medicine News, Future of MedicineTweet-
Generative AI helps Hong Kong’s @InSilicoMeds design potential new IBD drug #NBTntheNews via @scmpnews https://t.co/A7HzSeIKye
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Mashup Score: 111
Nature Biotechnology – Recombinases fused with zinc-finger domains are active only when bound to their DNA targets.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Recombinases fused with zinc-finger domains are active only when bound to their DNA targets https://t.co/LaF6kvk1Ia https://t.co/bl8k3I9JCV
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Mashup Score: 5
Recently, scientists at Insilico Medicine utilized the comprehensive generative chemistry engine Chemistry42 to discover a novel gut-restricted PHD inhibitor that shows promise for repairing the intestinal mucosal barrier and regulating immune responses in IBD. The study, published in Nature Biotechnology, highlights the role of Chemistry42 and its submodules in supporting drug candidate design and optimization. The research underscores the potential of advanced AI technologies to accelerate the fulfillment of urgent clinical needs.
Source: www.eurekalert.orgCategories: General Medicine News, Future of MedicineTweet-
Generative chemistry enables Insilico to develop gut-restricted PhD inhibitors promising for intestinal mucosal barrier repair and immunomodulation #NBTntheNews https://t.co/XrOG41gf9X
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Mashup Score: 5Discovering the crucial function of long noncoding RNAs - 9 day(s) ago
Nature Biotechnology – Discovering the crucial function of long noncoding RNAs
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Research Highlight: Discovering the crucial function of long noncoding RNAs https://t.co/gnLdpOgyQO
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An organoid model of the pancreas contains all three pancreatic cell lineages and can be cultured long-term https://t.co/fUGiuVUs2Z #NBThighlight