• Mashup Score: 15

    A team of scientists has identified specialized neurons in the brain that store “meal memories” detailed recollections of when and what we eat. These engrams, found in the ventral hippocampus, help regulate eating behavior by communicating with hunger-related areas of the brain. When these memory traces are impaired due to distraction, brain injury, or memory disorders individuals are more likely to overeat because they can’t recall recent meals. The research not only uncovers a critical neural mechanism but also suggests new strategies for treating obesity by enhancing memory around food consumption.

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    • Scientists found the brain glitch that makes you think you’re still hungry | @ScienceDaily https://t.co/w1MH8HDCFX

  • Mashup Score: 8

    New research indicates that Gen Xers and older Millennials are three to four times more likely to develop appendix cancer compared to those born in the 1940s. Appendix cancer is rare and regular screening is not common, so it’s important to talk with your doctor about any unusual abdominal symptoms.

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    • Rare Appendix Cancer Cases Rising in Gen Xers, Millennials https://t.co/B0ZskSymXB

  • Mashup Score: 3

    Background Cardiovascular diseases are the leading cause of mortality worldwide, with acute coronary syndrome (ACS) being particularly fatal. Percutaneous coronary intervention (PCI) is a key treatment for ACS; however, major adverse cardiovascular events (MACE) frequently occur postoperatively. Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been proposed as an emerging risk factor for cardiovascular disease. This study aims to systematically evaluate TMAO’s predictive value for MACE post-PCI and explore its dose-response relationship. Methods A comprehensive literature search was conducted in four databases (PubMed, Web of Science, Embase, and the Cochrane Library), including retrospective or prospective cohort studies involving patients undergoing PCI. The primary outcome was MACE, and the secondary outcome was all-cause mortality. A dose-response analysis was conducted using a restricted cubic spline model to explore potential nonlinear associations between

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    • Gut microbial metabolite trimethylamine N-oxide as a novel predictor for adverse cardiovascular events after PCI: a systematic review and dose-response meta-analysis | Nutrition Journal https://t.co/DlJ4RezuOu

  • Mashup Score: 11

    Bariatric surgery is internationally performed as a treatment option in obesity to achieve significant and sustained weight loss. There is an increasing number of women having pregnancies after bariatric surgery with mixed maternal and fetal outcomes, with a limited number of large, matched studies.

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    • RT @AJOG_thegray: #Pregnancy and offspring outcomes after prepregnancy #bariatric surgery https://t.co/DxW5NvzQ3d https://t.co/LhvqUZ72ku

  • Mashup Score: 8

    A team of scientists has discovered a direct link between the smell of food and feelings of fullness at least in lean mice. This brain circuit, located in the medial septum and triggered by food odors, helps animals eat less by making them feel satiated even before taking a bite. But intriguingly, obese mice lacked this response, highlighting how excess weight may interfere with this satiety mechanism. The finding could have major implications for how we think about the role of smell in appetite and offer new strategies to combat overeating.

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    • The hunger switch in your nose: How smells tell your brain to stop eating | @ScienceDaily https://t.co/VStgAPEXcX

  • Mashup Score: 26

    Tufts University scientists are aiming to revolutionize the future of weight loss drugs by engineering a new compound that targets four gut hormones instead of the usual one to three. These next-gen tetra-functional peptides may overcome the limitations of current drugs like Ozempic and Mounjaro especially their nausea, muscle loss, and rebound weight gain.

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    • Beyond Ozempic: New weight loss drug rivals surgery | @ScienceDaily https://t.co/CMtZcsGELm

  • Mashup Score: 3

    This JAMA Patient Page describes the use of cardiac computed tomography scans to look for calcium in the coronary arteries as a predictor of future atherosclerotic cardiovascular disease events.

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    • What Is a Cardiac CT Calcium Score? | Patient Information | JAMA | JAMA Network https://t.co/YFcKjP5b2c