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Mashup Score: 18
Abstract. Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and cause lethality. We show here that inhibition of Protein Phosphatase 2A (PP2A) hyperactivates multiple oncogenic pathways and engages stress responses in colon cancer cells. Genetic and compound screens identify combined inhibition of PP2A and WEE1 as synergistic in multiple cancer models by collapsing DNA replication and triggering premature mitosis followed by cell death. This combination also suppressed the growth of patient-derived tumors in vivo. Remarkably, acquired resistance to this drug combination suppressed the ability of colon cancer cells to form tumors in vivo. Our data s
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 18
Abstract. Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and cause lethality. We show here that inhibition of Protein Phosphatase 2A (PP2A) hyperactivates multiple oncogenic pathways and engages stress responses in colon cancer cells. Genetic and compound screens identify combined inhibition of PP2A and WEE1 as synergistic in multiple cancer models by collapsing DNA replication and triggering premature mitosis followed by cell death. This combination also suppressed the growth of patient-derived tumors in vivo. Remarkably, acquired resistance to this drug combination suppressed the ability of colon cancer cells to form tumors in vivo. Our data s
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
When too much of a good thing ends badly... super cool new paper showing that over activation of oncogenic signaling pathways leads to cell death @CD_AACR @MedemaRene https://t.co/Q754IPNG4C
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Mashup Score: 12Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns - 2 month(s) ago
Nature Genetics – This study examines karyotypic selection and evolution in vitro using immortalized mammary and kidney epithelial cell lines, observing aneuploidy patterns specific to each origin…
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
Huge congrats to my friend and colleague @game_of_chroms on her incredible paper where she describes evolution of fit karyotypes following aneuploidization and found that they match the karyotypes in patient cancers. https://t.co/I6AKXPbFiQ
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Mashup Score: 6
Nature – Scientists spot a particle of intense energy, but explaining where it came from might require some new physics.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
Next up in Rad Onc: 240 exa-electronvolts (EeV; 10^18 electronvolts) therapy. The most powerful cosmic ray since the Oh-My-God particle puzzles scientists https://t.co/1OjZGapYMT
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Mashup Score: 3Fixed Term (12 months) up to 3.0FTE Postgraduate Fellow - Radiation Oncology - Westmead Hospital | APPLY VIA ECREDENTIAL | I work for NSW - 8 month(s) ago
Fixed Term (12 months) up to 3.0FTE Postgraduate Fellow Department of Radiation Oncology Westmead Hospital CLICK HERE TO APPLY Applications are inv…
Source: iworkfor.nsw.gov.auCategories: Latest Headlines, Oncologists1Tweet-
RT @RadOncDoc_Gee: We have fantastic fellowships available with protected research time! pls RT https://t.co/XufXPkQw2e @SarahLeeson9 @Carm…
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Mashup Score: 4Need for Evidence-Based Adoption of New Technologies in Radiotherapy - 9 month(s) ago
This Viewpoint discusses the need for multi-institutional prospective randomized trials of new technologies in radiotherapy to improve the therapeutic ratio and safety of radiotherapy treatments.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Kudos to @NiuSanford @ParikhSimul @SprakerMDPhD for this article. Just because we can do something fancy, doesn't mean we should. Just because its safe, doesn't mean it's better. https://t.co/qeXMlhiLQR
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Mashup Score: 3A survey of CIN measures across mechanistic models - 11 month(s) ago
Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression. However, mis-segregation rates remain challenging to assess in human cancer despite an array of available measures. We evaluated measures of CIN by comparing quantitative…
Source: bioRxivCategories: Hem/Oncs, Latest HeadlinesTweet-
I have been very excited to share this work by @AndrewLynchBio @meburkard which shows the methods that can actually quantify chromosome missegregation events (CIN) and spoiler alert: previously published transcriptomic signatures do NOT detect CIN😬 https://t.co/3IEf8xCFtr
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Mashup Score: 0
The switch from glucose- to fatty acid-dependent metabolism in cardiomyocytes of newborn mice is governed by γ-linolenic acid in maternal milk, which binds to retinoid X receptors, thereby causing a transcription-dependent metabolic transition.
Source: NatureCategories: Latest Headlines, Oncologists1Tweet-
This group milked mice. With their hands. (and made interesting discoveries resulting in a Nature paper) but THEY MILKED MICE y'all https://t.co/O6b8f0dTNu
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Mashup Score: 10
This cross-sectional study assesses the frequency of reporting of primary end point changes among active oncology phase 3 randomized clinical trials.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Oh lord. Out of 755 oncology phase 3 RCT trials, 20% changed their primary endpoint after the study started. This was associated with trial positivity (!!) and 70% of these did not disclose these changes in the manuscript. What are we doing here??? 😵 https://t.co/T4KEQDYgue
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Mashup Score: 2How a simple idea to share lab materials led to a circular-economy movement in science - 12 month(s) ago
Garry Cooper’s sustainability business has grown to help thousands of people conduct more efficient research.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
This is brilliant - like a ride share program for labs! One lab with unused items can help another (resource poor) lab get what they need! Great for sustainability too 🌎. https://t.co/ckPauawAGX
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When too much of a good thing ends badly... super cool new paper showing that over activation of oncogenic signaling pathways leads to cell death @CD_AACR @MedemaRene https://t.co/Q754IPNG4C