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Mashup Score: 1
Abstract. Purpose: Tissue derived tumor mutation burden (TMB) of ≥10 mutations/Mb is a histology agnostic biomarker for the immune checkpoint inhibitor (ICI) pembrolizumab. However, the dataset on which this was validated lacked colorectal cancers (CRCs), and there is limited evidence for immunotherapy benefit in CRC using this threshold. Patients and Methods: CO.26 was a randomized phase II study of 180 patients comparing durvalumab and tremelimumab (D+T, n=119 patients) versus best supportive care (BSC, n=61 patients). ctDNA sequencing was available for 168 patients (n=118 D+T, n=50), of which 165 had evaluable plasma TMB (pTMB). Tissue sequencing was available for 108 patients. Optimal thresholds for stratifying patients based on overall survival were determined using a minimal p-value approach. This report includes the final overall survival analysis. Results: Tissue TMB ≥10 mutations/Mb was not predictive of benefit from D+T compared to BSC in microsatellite stable (MSS) metastati
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3LOAd703, an Oncolytic Virus–Based Immunostimulatory Gene Therapy, Plus Chemotherapy for Unresectable or Metastatic Pancreatic Cancer - 2 day(s) ago
Read it now on PracticeUpdate.com
Source: www.practiceupdate.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4ASCO Releases Vaccination Guidelines for Adults With Cancer - 1 month(s) ago
Oncologists may be key in ensuring patients with cancer safely receive vaccinations and avert avoidable infections.
Source: www.mdedge.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0John Lennon's son Sean Lennon wins Oscar and pays emotional tribute to his mother Yoko Ono - 2 month(s) ago
A touching moment at the 2024 Oscars saw Sean Ono Lennon pick up a prize and pay tribute to his mother Yoko.
Source: www.goldradiouk.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Pan-cancer proteogenomics characterization of tumor immunity - 3 month(s) ago
Despite the successes of immunotherapy in cancer treatment over recent decades, less than <10%–20% cancer cases have demonstrated durable responses fr…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4An Open Letter to End Drug Shortages - 3 month(s) ago
Sign the letter and urge policymakers to end drug shortages!
Source: asco.quorum.usCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
Dana-Farber Cancer Institute retracts six papers and corrects more than 30 after data changes found.
Source: www.mdedge.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
Dana-Farber Cancer Institute retracts six papers and corrects more than 30 after data changes found.
Source: www.mdedge.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0
Despite the remarkable success of anti-cancer immunotherapy, its effectiveness remains confined to a subset of patients—emphasizing the importance of …
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Where Is the ‘Microbiome Revolution’ Headed Next? - 4 month(s) ago
Important advances are coming our way in the next 5-10 years.
Source: www.mdedge.comCategories: General Medicine News, Hem/OncsTweet
Plasma versus tissue tumor mutational burden as biomarkers of durvalumab plus tremelimumab response in patients with metastatic colorectal cancer in the CO.26 trial https://t.co/Cf928dku44