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Mashup Score: 97
Perioperative stroke, defined as a cerebrovascular event occurring during surgery or within 30 days postoperatively, remains a devastating complication associated with substantial morbidity, disability, mortality, and increased healthcare utilization. Although overall incidence is relatively low—up to 1% in most surgical populations—it is significantly elevated in cardiac, major vascular, and neurosurgical procedures, often exceeding 5%. The rising prevalence of perioperative stroke, primarily driven by an aging surgical population burdened by multiple chronic vascular conditions and increasingly eligible for high-risk surgical interventions, underscores the urgency of optimizing preventive and management strategies. This review synthesizes insights into patient- and procedure-related risk factors, highlighting the intricate interplay of embolic, thrombotic, and hypoperfusion mechanisms underpinning perioperative ischemic strokes. Key patient-specific risks include advanced age, recent
Source: www.ahajournals.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 152Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis | Neurology - 12 day(s) ago
ObjectivesGiven the high risk of recurrent atherosclerotic vascular events in patients with stroke due to intracranial atherosclerotic disease (ICAD), we estimated the potential benefit of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
Every 10 mg/dL ⬇️ in LDL for patients with ICAD stroke has 9% ⬇️ rates of recurrent stroke or MI. this theoretical framework suggests that PCSK9i can help achieve this. We need PCSK-9i trials in ICAD @JimSiegler @TareqKass @GhannamMalik @ChaturvediNeuro https://t.co/xjR346jUxs
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Mashup Score: 152Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis | Neurology - 12 day(s) ago
ObjectivesGiven the high risk of recurrent atherosclerotic vascular events in patients with stroke due to intracranial atherosclerotic disease (ICAD), we estimated the potential benefit of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
Every 10 mg/dL ⬇️ in LDL for patients with ICAD stroke has 9% ⬇️ rates of recurrent stroke or MI. this theoretical framework suggests that PCSK9i can help achieve this. We need PCSK-9i trials in ICAD @JimSiegler @TareqKass @GhannamMalik @ChaturvediNeuro https://t.co/xjR346jUxs
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Mashup Score: 35Composition, Treatment, and Outcomes by Radiologically Defined Thrombus Characteristics in Acute Ischemic Stroke | Stroke - 2 month(s) ago
Occlusive and nonocclusive cervicocephalic thrombi can be encountered during neurovascular imaging in patients with acute ischemic stroke. Radiographic and morphological characteristics on basic and advanced imaging modalities can be important clues towards determination of pathomechanism and the choice of acute and subacute treatment modalities. The aim of this review article is to evaluate the epidemiology, radiographic properties, histologic clot composition of cervicocephalic arterial thrombi, and its response to various medical and endovascular therapy modalities. Future studies are needed to derive and validate a classification system for extracranial and intracranial partially occlusive thrombi to enable further testing of various stroke treatment and prevention strategies in these patients. Graphical Abstract
Source: www.ahajournals.orgCategories: General Medicine News, NeurologyTweet-
My practice is to use heparin when safe and repeat imaging in ~48 hours then transition to a DOAC, VKA, or LMWH for a short period then AP. It is also reasonable to use DAPT. Check out this review to learn more about this topic: https://t.co/25Vsr6qfKG
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Mashup Score: 11The world’s 20 best cities for food right now - 3 month(s) ago
We asked thousands of locals to rate their city’s food scene – these are the results.
Source: www.timeout.comCategories: General Medicine News, NeurologyTweet-
RT @bijoymenon: ISC2026 is at New Orleans! Enjoy the best stroke science at the best city in the world for food! https://t.co/jEpu1KobbS @A…
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Mashup Score: 0Dr. Glaucomflecken (@docglauc) • Instagram reel - 4 month(s) ago
12K likes, 185 comments – docglauc on February 7, 2025: “The med student faces his greatest challenge”.
Source: www.instagram.comCategories: General Medicine News, NeurologyTweet-
The standardized neuro-exam 😂 #stroke #neurotwitter https://t.co/OwCTTpH5yr
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Mashup Score: 208Anticoagulation vs Antiplatelets Across Subgroups of Embolic Stroke of Undetermined Source | Neurology - 4 month(s) ago
Background and ObjectivesThe term “embolic stroke of undetermined source” (ESUS) encompasses a substantial but heterogeneous population of patients with ischemic stroke, underscoring the importance of identifying personalized treatment strategies. In …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
Is anticoagulation superior in of the ESUS subgroups? #stroke #esus #meded Check out this meta-analysis of randomized controlled trials of ESUS patients investigating the efficacy of anticoagulation compared to antiplatelets based on various mechanisms. https://t.co/QXs4RyP95M https://t.co/7luucpyGjL
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Mashup Score: 73Emergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study | Stroke - 4 month(s) ago
Background: The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact of emergent carotid stenting during endovascular treatment (EVT) for acute ischemic stroke (AIS) in patients with tandem occlusion secondary to cervical carotid artery dissection. Methods: This was a secondary analysis of patients treated with EVT for AIS due to occlusive carotid artery dissection and tandem occlusion included in the retrospective international Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection (STOP-CAD) study. We compared patients with and without emergent stenting. The primary efficacy and safety outcomes were 90-day functional independence (modified Rankin Scale 0-2) and symptomatic intracranial hemorrhage (sICH) within 24h after EVT. Procedural outcome was successful intracranial recanalization (mTICI 2b/3). We used mixed-effect logistic regression adjusting for site, age, and NIHSS. In addi
Source: www.ahajournals.orgCategories: General Medicine News, NeurologyTweet-
🛑CAD analysis: Should tandem lesions in the setting of dissection be stented? Here is a secondary analysis of the STOP-CAD study showing increased odds of any ICH but sICH but improved reperfusion with stenting and NO difference in mRS at 90 days. https://t.co/wwwH6Evvp2
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Mashup Score: 69Emergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study | Stroke - 4 month(s) ago
Background: The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact of emergent carotid stenting during endovascular treatment (EVT) for acute ischemic stroke (AIS) in patients with tandem occlusion secondary to cervical carotid artery dissection. Methods: This was a secondary analysis of patients treated with EVT for AIS due to occlusive carotid artery dissection and tandem occlusion included in the retrospective international Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection (STOP-CAD) study. We compared patients with and without emergent stenting. The primary efficacy and safety outcomes were 90-day functional independence (modified Rankin Scale 0-2) and symptomatic intracranial hemorrhage (sICH) within 24h after EVT. Procedural outcome was successful intracranial recanalization (mTICI 2b/3). We used mixed-effect logistic regression adjusting for site, age, and NIHSS. In addi
Source: www.ahajournals.orgCategories: General Medicine News, NeurologyTweet-
🛑CAD analysis: Should tandem lesions in the setting of dissection be stented? Here is a secondary analysis of the STOP-CAD study showing increased odds of any ICH but sICH but improved reperfusion with stenting and NO difference in mRS at 90 days. https://t.co/wwwH6Evvp2
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Mashup Score: 80Endovascular Thrombectomy for Extracranial Internal Carotid Artery Occlusions With Large Ischemic Strokes | Neurology - 4 month(s) ago
Background and ObjectivesAlthough previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most of them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
Let’s admire the power of mechanical thrombectomy in stroke patients seen in this analysis from SELECT-2. Only 62 patients were included with large core & tandem lesions ASPECTS 3-5: OR 4.5 for independent ambulation & 2.5 for mRS, p<0.05. @amrsarrajMD https://t.co/UXWIH8AW3h
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Check out this review on risk stratification and management of perioperative stroke. @StrokeAHA_ASA @NguyenThanhMD https://t.co/g9cpzQ1AAg