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Mashup Score: 29Rescue Stenting for Failed Mechanical Thrombectomy in Acute Basilar Artery Occlusions: Analysis of the PC-SEARCH Registry | Stroke - 13 hour(s) ago
Background: We aimed to investigate whether rescue stenting (RS) following failed mechanical thrombectomy (MT) for acute basilar artery occlusion (BAO) results in superior functional outcomes and enhanced safety compared to the natural history of failed mechanical thrombectomy (MT). Methods: This retrospective cohort study utilized data from the PC-SEARCH registry, encompassing eight high-volume centers in the United States and covering the period from 2015 to 2021. Patients with BAO who experienced failed MT (mTICI score of 0-2a after at least one attempt of clot retrieval) were categorized based on whether they received additional intervention with RS. The primary outcome was a shift analysis of the 90-day mRS. Multivariable logistic regression was employed to assess both efficacy and safety outcomes. Results: Of a total of 444 patients, 119 presented failed MT and were included in the analysis. The RS group comprised 65 (14.6%) patients, while the control group consisted of 54 (12.2
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 14Natural Evolution of Incomplete Reperfusion in Patients following Endovascular Therapy after Ischemic Stroke | Stroke - 1 day(s) ago
Background: A third of endovascularly treated stroke patients experience incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction, eTICI<3) and the natural evolution of this incomplete reperfusion remains unknown. We systematically reviewed literature and performed a meta-analysis on the natural evolution of incomplete reperfusion after endovascular therapy. Methods: A systematic review of MEDLINE, Embase and PubMed up until March 1, 2024 using a predefined strategy. Only full-text English written articles reporting rates of either favorable (i.e., delayed reperfusion or no new infarct) or unfavorable progression (i.e., persistent perfusion deficit or new infarct) of incompletely reperfused tissue were included. Primary outcome was the rate of delayed reperfusion and its association with functional independence (modified Rankin Scale, mRS 0–2) at 90 days post-intervention. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using a random-effects mode
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Check out the article, "Natural Evolution of Incomplete Reperfusion in Patients Following Endovascular Therapy After Ischemic Stroke," by @adnan_mujanovic et al, being presented at #SVIN24. #stroke #AHAJournals @SVINJournal @svinsociety https://t.co/vLcwkQKuqN
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Mashup Score: 25
Clinical trials are essential for advancing medical treatments, but most landmark randomized controlled trials exclude patients with lower probabilities of achieving good outcomes, even if these patients could still benefit from mechanical thrombectomy (MT). Real-world registries, however, can capture MT benefits outside of clinical trial settings, including a broader patient population, such as those with lower NIHSS scores, lower ASPECTS scores, distal occlusions, and presentations in late time
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Article Commentary: “EXCELLENT Registry: Prospective, Multicenter, Global Registry of Endovascular Stroke Treatment With the EMBOTRAP Device” #BloggingStroke contributor @MDStebnerAl discusses this article presented today at #SVIN24. #stroke #AHAJournals https://t.co/tveiIByvII https://t.co/q4Yq3gZIO5
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Mashup Score: 14EXCELLENT Registry: A Prospective, Multicenter, Global Registry of Endovascular Stroke Treatment With the EMBOTRAP Device | Stroke - 2 day(s) ago
BACKGROUND: The EXCELLENT registry aimed to evaluate the effectiveness of the EMBOTRAP Revascularization Device in an all-comer population in a real-world setting, with a focus on the composition of retrieved clots. METHODS: EXCELLENT is a prospective, global registry of patients with acute ischemic stroke treated with EMBOTRAP as the first-line mechanical thrombectomy device conducted at 34 sites (25 sites contributing clot) from September 2018 to March 2021, utilizing core imaging and central histology laboratories blinded to clinical data, independent 90-day modified Rankin Scale assessment and Clinical Events Committee. RESULTS: After screening 3799 patients, a total of 997 subjects (mean age, 70.0±14.2 years; 51.8% women; 19.7% non-White) were included. The first-pass modified Treatment in Cerebral Infarction (mTICI) ≥2b rate was 64.5% (623/966), first-pass mTICI ≥2c was 39.1% (378/966), and final mTICI ≥2b was 94.5% (931/985). A total of 427/912 (46.8%) patients achieved a 90-day
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: The EXCELLENT registry examines the interaction between retrieved thrombus composition and clinical factors among patients undergoing EVT with the EMBOTRAP device. #SVIN24 #AHAJournals @SVINJournal @svinsociety @RaulNogueiraMD https://t.co/kr0dUU9Cp1 https://t.co/UlW00CkBj7
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Mashup Score: 3NSAID Allergy Labels Associated With Mortality and Cardiovascular Outcomes in Stroke | Stroke - 3 day(s) ago
BACKGROUND: Mislabeled drug allergy can restrict future prescriptions and medication use, but its prevalence and impact among patients with stroke remain unknown. This study investigated the prevalence of the most commonly labeled drug allergies, their accuracy, and their impact among patients with stroke. METHODS: In this combined longitudinal and cross-sectional study, we compared the prevalence of allergy labels among the general population and patients with ischemic stroke between 2008 and 2014 from electronic health care records in Hong Kong. Outcomes between patients with stroke with or without the most prevalent labels (ie, NSAID) were compared. Rate of mislabeled NSAID allergy was confirmed by provocation testing. RESULTS: Compared with the general population (n=702 966), patients with stroke had more labels (n=235) to cardiovascular and hematopoietic system (prevalence, 19.5% versus 9.2%; odds ratio [OR], 2.4 [95% CI, 1.74–3.32]; P<0.001) and radiographic and diagnostic agents
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Check out the article "NSAID Allergy Labels Associated With Mortality and Cardiovascular Outcomes in Stroke" ⬇️ #AHAJournals @DrWilliamLeung https://t.co/PyTowigT9x
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Mashup Score: 30Optogenetic Functional Activation Is Detrimental During Acute Ischemic Stroke in Mice | Stroke - 3 day(s) ago
BACKGROUND: Functional activation of the focal ischemic brain has been reported to improve outcomes by augmenting collateral blood flow. However, functional activation also increases metabolic demand and might thereby worsen outcomes. Indeed, preclinical and clinical reports have been conflicting. Here, we tested the effect of functional activation during acute ischemic stroke using distal middle cerebral artery occlusion in anesthetized mice. METHODS: Using transgenic mice expressing channelrhodopsin-2 in neurons, we delivered functional activation using physiological levels of transcranial optogenetic stimulation of the moderately ischemic cortex (ie, penumbra), identified using real-time full-field laser speckle perfusion imaging during a 1-hour distal microvascular clip of the middle cerebral artery. Neuronal activation was confirmed using evoked field potentials, and infarct volumes were measured in tissue slices 48 hours later. RESULTS: Optogenetic stimulation of the penumbra was
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: Increased neuronal activity during acute focal arterial occlusions can be detrimental in 🐁, presumably due to increased metabolic demand. This may have implications for the clinical management of hyperacute stroke patients. #AHAJournals https://t.co/0MryrFe693 https://t.co/GepkG5cNP1
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Mashup Score: 8Decreased Quantitative Cerebral Blood Volume Is Associated With Poor Outcomes in Large Core Patients | Stroke - 4 day(s) ago
BACKGROUND: Recent large core trials have highlighted the effectiveness of mechanical thrombectomy (MT) in acute ischemic stroke with large vessel occlusion. Variable perfusion-imaging thresholds and poor Alberta Stroke Program Early Computed Tomography Score reliability underline the need for more standardized, quantitative ischemia measures for MT patient selection. We aimed to identify the computed tomography perfusion parameter most strongly associated with poor outcomes in patients with acute ischemic stroke-large vessel occlusion with significant ischemic cores. METHODS: In this study from 2 comprehensive stroke centers from 2 comprehensive stroke centers within the Johns Hopkins Medical Enterprise (Johns Hopkins Hospita—East Baltimore and Bayview Medical Campus) from July 29, 2019 to January 29, 2023 in a continuously maintained database, we included patients with acute ischemic stroke-large vessel occlusion with ischemic core volumes defined as relative cerebral blood flow <30%
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Check out the article, "Decreased Quantitative Cerebral Blood Volume Is Associated With Poor Outcomes in Large Core Patients," by @vsyedavalli @hamza_isleem et al. ⬇️ https://t.co/AhYcLANbaN
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Mashup Score: 17Article Commentary: “Diastolic Dysfunction and the Risk of Stroke and Major Bleeding” - 6 day(s) ago
Left ventricular diastolic dysfunction (DD) is a common cardiac condition characterized by impaired relaxation and elevated filling pressures of the left ventricle. While DD has been associated with various cardiovascular complications, its relationship to stroke risk and major bleeding events has remained unclear — until now. A groundbreaking new study published in Stroke sheds light on the independent association between DD and the risk of both ischemic stroke and major bleeding events. Kundrick and
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
Article Commentary: "Diastolic Dysfunction and the Risk of Stroke & Major Bleeding" #BloggingStroke contributor @DrRamiMorsi discusses #Stroke article by Kundrick & Saba et al. #AHA24 #AHAJournals @KrishKancharla @Aditi_Nani @Saba_sfs3 @PittCardiology https://t.co/VLscKo6RcQ https://t.co/y82BdJCIAx
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Mashup Score: 12
BACKGROUND: Left ventricular diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes including atrial fibrillation. Whether DD is independently associated with incident stroke and transient ischemic attack (TIA) and with bleeding events is not known. We performed this observational cohort analysis to examine the impact of DD on the risk of stroke/TIA and major bleeding. METHODS: Patients who underwent at least 1 cardiac echocardiogram and were followed for at least 3 months were included in this study. Patients with a prior history of stroke, TIA, or major bleeding, as determined by International Classifications of Diseases codes, were excluded. Smart key-phrase search was applied to echocardiographic reports to classify patients into 4 groups based on the most severe DD assessment. Patients in whom the presence of DD could not be determined were excluded. The final study cohort was followed to the end point of hospital admission for stroke/TIA and major bleeding,
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#STROKE: The risks of stroke and major bleeding increase with worsening grades of diastolic dysfunction, independent of history of atrial fibrillation. #AHA24 #AHAJournals @KrishKancharla @Aditi_Nani @Saba_sfs3 @PittCardiology https://t.co/GmGXmBYl0J https://t.co/uTs1Et84ep
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Mashup Score: 4AHA24 - 7 day(s) ago
Download the mobile program today to easily access event session s, speakers, exhibitors, and organizer messages. Use the native app to personalize your schedule, take notes, share contacts, and more. Build your schedule directly on your computer. Then, install the native app and sync your schedule to your mobile
Source: eppro01.ativ.meCategories: General Medicine News, CardiologistsTweet-
Join #AHAJournals in celebrating the Dr. Nanette K. Wenger Research Goes Red® Award winner. #AHA24 Saturday, Nov 16 @ 9:45-11am CT Room: S100A https://t.co/9D7twutdPq
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#STROKE: Rescue stenting in acute basilar artery occlusion is associated with improved functional outcomes and reduced mortality after mechanical thrombectomy failure, an analysis of the PC-SEARCH registry. #SVIN24 #AHAJournals https://t.co/syrmWcV6n7 https://t.co/LfMJlvJaGr