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Mashup Score: 60
Insufficient evidence was available to establish a difference between an active blood-pressure-lowering strategy—in which antihypertensive agents were administered to reduce blood pressure below 185/110 mm Hg—and a non-lowering strategy for the functional outcomes of patients with ischaemic stroke, despite higher intravenous thrombolysis rates and shorter door-to-needle times among those in the active blood-pressure-lowering group. Randomised controlled trials are needed to inform the use of an active blood-pressure-lowering strategy.
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Mashup Score: 6Climate change and disorders of the nervous system - 1 day(s) ago
Anthropogenic climate change is affecting people’s health, including those with neurological and psychiatric diseases. Currently, making inferences about the effect of climate change on neurological and psychiatric diseases is challenging because of an overall sparsity of data, differing study methods, paucity of detail regarding disease subtypes, little consideration of the effect of individual and population genetics, and widely differing geographical locations with the potential for regional influences.
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Mashup Score: 2B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases - 1 day(s) ago
Neuroimmunology research and development has been marked by substantial advances, particularly in the treatment of neuroimmunological diseases, such as multiple sclerosis, myasthenia gravis, neuromyelitis optica spectrum disorders, and myelin oligodendrocyte glycoprotein antibody disease. With more than 20 drugs approved for multiple sclerosis alone, treatment has become more personalised. The approval of disease-modifying therapies, particularly those targeting B cells, has highlighted the role of immunotherapeutic interventions in the management of these diseases.
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Mashup Score: 0Forging ahead in haemorrhagic stroke research - 1 day(s) ago
Haemorrhagic stroke has a poor prognosis and is challenging to treat. However, strides in research over the past few years mean that promising treatment and secondary prevention strategies are emerging. Researchers are tackling the major issues in haemorrhagic stroke, including the benefits of ultra-early and intensive blood pressure lowering; when, for whom, and which approach to use for surgical management; and the optimal strategy for secondary prevention. Such advances are being discussed during the 10th European Stroke Organisation Conference, May 15–17, 2024, in Basel, Switzerland.
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Mashup Score: 50
Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide
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Mashup Score: 7About The Lancet Neurology - 24 day(s) ago
About
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Mashup Score: 12
This pilot phase trial exceeded its recruitment target, but a definitive trial will require extensive international engagement.
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Mashup Score: 0Association of Pick's disease with the MAPT H2 haplotype - 28 day(s) ago
One of the main players in the pathogenesis of neurodegenerative diseases is the microtubule-associated protein tau. Tau aggregation is involved in Alzheimer’s disease, in which it co-occurs with amyloid pathology, and in primary tauopathies (including frontotemporal dementia, progressive supranuclear palsy, or corticobasal degeneration), in which aggregation can occur in neurons or glial cells. Yet, despite some overlap, these diseases differ strikingly from each other clinically, with a spectrum of symptoms including behavioural changes, executive dysfunction, language or memory impairment, and extrapyramidal features.
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Mashup Score: 15MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study - 28 day(s) ago
The Pick’s disease International Consortium provides an opportunity to do large studies to enhance our understanding of the pathobiology of Pick’s disease. This study shows that, in contrast to the decreased risk of four-repeat tauopathies, the MAPT H2 haplotype is associated with an increased risk of Pick’s disease in people of European ancestry. This finding could inform development of isoform-related therapeutics for tauopathies.
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Mashup Score: 8New gene involved in the pathogenesis of Parkinson's disease - 1 month(s) ago
Parkinson’s disease is defined by the presence of progressive motor dysfunction, but many patients also experience challenging non-motor symptoms, including cognitive impairment in advanced disease stages. No treatment is available to slow or stop disease progression. Our understanding of Parkinson’s disease aetiology is insufficient, and novel insights into pathogenic mechanisms are needed to pave the way for improved diagnostics and new therapeutic strategies. Genetic research has had a major role in elucidating the pathogenesis of Parkinson’s disease on a molecular level.
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ONLINE FIRST: Read the TRUTH trial, comparing two strategies for the treatment of patients with acute ischaemic stroke and increased blood pressure precluding intravenous thrombolysis: https://t.co/n9aI5wwKOP Presented at #ESOC2024