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Mashup Score: 30
Non-diphtheriae Corynebacterium species are Gram-positive catalase-positive rod-shaped bacteria that are ubiquitous in the environment and are commensal organisms of human mucosal surfaces (1). However, non-diphtheriae Corynebacterium species have emerged as clinically significant opportunistic pathogens, particularly in immunocompromised individuals and those with indwelling medical devices, causing a wide spectrum of clinical infections (1–5). Furthermore, management of infection is often complicated by the resistance of non-diphtheriae Corynebacterium species to multiple classes of antibiotics, impairing the selection of effective empiric and definitive therapy (6). In this context, with the increasing recognition of the clinical significance of these microorganisms, a comprehensive understanding of their antimicrobial susceptibility profiles to guide effective therapeutic strategies is needed and, in comparison to more routine culprit pathogens, data on species-specific susceptibil
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 3ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells | Journal of Virology - 8 day(s) ago
Influenza virus is the etiological agent behind some of the most devastating infectious disease pandemics to date, and influenza outbreaks still pose a major threat to public health. Influenza virus polymerase, the molecule that copies the viral RNA …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
Sometimes they are mutations that enhance permissivity, or the ability of a virus to replicate once it’s inside the host cell. The PB2 E672K mutation is an example, as it enables interaction with a host protein called ANP32 required for replication. https://t.co/SRd3WnLhvg
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Mashup Score: 14Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems | Journal of Bacteriology - 12 day(s) ago
Defense systems are immunity systems that allow bacteria to counter the threat posed by bacteriophages and other mobile genetic elements. Although these systems are numerous and highly diverse, the most common types are restriction enzymes that can …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
✔️ Attending #EMBLInfectionBiology tomorrow? Don't miss 'Deciphering Defense Systems of 7th Pandemic Vibrio cholerae' by Dr. Melanie Blokesch (@MBlokesch) from @EPFL_en! Check out their work here: https://t.co/TijDwnkrMa 📅 Event Program: https://t.co/DaavFK9jN1 https://t.co/KcT3tH6hP9
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Mashup Score: 0Acquisition of a multibasic cleavage site does not increase MERS-CoV entry into Calu-3 human lung cells | Journal of Virology - 12 day(s) ago
The highly cleavable furin motif in the spike protein is required for robust lung cell entry, transmission, and pathogenicity of SARS-CoV-2. In contrast, it is unknown whether optimization of the furin motif in the spike protein of the pre-pandemic MERS-…
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
😷 By employing pseudotyped particles, scientists investigated whether augmented cleavage at the S1/S2 site also increases #MERS-CoV entry into Calu-3 human #lung cells. 👉 https://t.co/u0oJWlJXrT https://t.co/33uCyjiGPv
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Mashup Score: 93The Brief Case: Sister Fungi in a Patient with AIDS | Journal of Clinical Microbiology - 19 day(s) ago
A 30-year-old female with advanced human immunodeficiency virus (HIV) type 1 infection was transferred to our institution for evaluation of persistent cough and recurrent fevers of unknown origin. She had immigrated from the Philippines to the United States 3 years ago and first came to medical attention at an outside institution 12 weeks prior to current presentation after experiencing 2 months of cough, night sweats, and fevers. Testing at that time revealed Pneumocystis jirovecii pneumonia (PJP) and HIV infection, with an HIV load of 210,000 copies/mL and a CD4 T lymphocyte count of 13 cells/μL (reference range, 500 to 1,200 cell/μL). She was hospitalized for 7 days and treated with trimethoprim-sulfamethoxazole and prednisone for PJP, which was later switched to atovaquone after she developed acute kidney injury (AKI). She was also started on a combination antiretroviral therapy (ART) of bictegravir, emtricitabine, and tenofovir alafenamide for HIV infection.
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
#MayoIDCase #IDBR Young woman, HIV, CD4 13, recent PJP & CMV retinitis CC: dyspnea, fever, renal failure. Kidney histopathology: tubules containing small Gram-positive spores (A) that are focally acid-fast (B). What is your differential diagnosis? https://t.co/T336MxjRsn https://t.co/BMyLnMxlOF
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Mashup Score: 10Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity | Journal of Virology - 24 day(s) ago
This study shows how herpes simplex virus type 1 (HSV-1) spreads within the brain after infecting the nasal passages. Our data reveal the distinct pattern of HSV-1 through the brain during a non-encephalitic infection. Furthermore, microglial activation …
Source: journals.asm.orgCategories: General Medicine News, NeurologyTweet-
“Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity” by Christy Niemeyer et al. Journal of Virology https://t.co/VPepdgMcza
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Mashup Score: 84The Brief Case: Sister Fungi in a Patient with AIDS | Journal of Clinical Microbiology - 24 day(s) ago
A 30-year-old female with advanced human immunodeficiency virus (HIV) type 1 infection was transferred to our institution for evaluation of persistent cough and recurrent fevers of unknown origin. She had immigrated from the Philippines to the United States 3 years ago and first came to medical attention at an outside institution 12 weeks prior to current presentation after experiencing 2 months of cough, night sweats, and fevers. Testing at that time revealed Pneumocystis jirovecii pneumonia (PJP) and HIV infection, with an HIV load of 210,000 copies/mL and a CD4 T lymphocyte count of 13 cells/μL (reference range, 500 to 1,200 cell/μL). She was hospitalized for 7 days and treated with trimethoprim-sulfamethoxazole and prednisone for PJP, which was later switched to atovaquone after she developed acute kidney injury (AKI). She was also started on a combination antiretroviral therapy (ART) of bictegravir, emtricitabine, and tenofovir alafenamide for HIV infection.
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
#MayoIDCase #IDBR Young woman, HIV, CD4 13, recent PJP & CMV retinitis CC: dyspnea, fever, renal failure. Kidney histopathology: tubules containing small Gram-positive spores (A) that are focally acid-fast (B). What is your differential diagnosis? https://t.co/T336MxjRsn https://t.co/BMyLnMxlOF
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Mashup Score: 21
Our study addresses a significant knowledge gap in the clinical management of this non-Candida albicans species. Our retrospective review includes comprehensive AST data for 112 Candida guilliermondii isolates, which is the largest number of isolates …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
Publication Alert Candida guilliermondii fungemia: a 12-year review of antimicrobial susceptibility patterns at a reference laboratory and tertiary care center. Congratulations Drs. @jamchugh @IDdocAdi @NischalR3 @stevens_AK https://t.co/jukFrT7ylf
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Mashup Score: 4
A 72-year-old man from rural Minnesota presented to the emergency department in November 2023 with a 4-day history of fever, chills, vomiting, diarrhea, cough, and shortness of breath. He had underlying sarcoidosis, bronchiectasis, paroxysmal atrial fibrillation, and sinus bradycardia and had a pacemaker in place. He reported extensive zoonotic exposures in Minnesota during the 2 weeks before presentation, including deer hunting until 5 days before the symptom onset, consumption of cooked game meat, and freshwater exposure. In addition, on the day of symptom onset, he had manually removed and discarded two engorged ticks from his abdomen. In the emergency department, he was febrile and developed atrial fibrillation with rapid ventricular response and hypotension. Because of the concern for sepsis, he was given intravenous cefepime, vancomycin, and metronidazole, and oral doxycycline; 4 h after administration of this antimicrobial regimen, he developed severe hemodynamic instability. Hy
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
PCR / molecular test of the blood has highest sensitivity for diagnosis of leptospirosis in a patient within 6 days of symptoms in whom serology is still negative. You can read more of leptospirosis and this case report of our fellow Dr MJ Kim here: https://t.co/87Xl7HKObV
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Mashup Score: 3
A 72-year-old man from rural Minnesota presented to the emergency department in November 2023 with a 4-day history of fever, chills, vomiting, diarrhea, cough, and shortness of breath. He had underlying sarcoidosis, bronchiectasis, paroxysmal atrial fibrillation, and sinus bradycardia and had a pacemaker in place. He reported extensive zoonotic exposures in Minnesota during the 2 weeks before presentation, including deer hunting until 5 days before the symptom onset, consumption of cooked game meat, and freshwater exposure. In addition, on the day of symptom onset, he had manually removed and discarded two engorged ticks from his abdomen. In the emergency department, he was febrile and developed atrial fibrillation with rapid ventricular response and hypotension. Because of the concern for sepsis, he was given intravenous cefepime, vancomycin, and metronidazole, and oral doxycycline; 4 h after administration of this antimicrobial regimen, he developed severe hemodynamic instability. Hy
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
PCR / molecular test of the blood has highest sensitivity for diagnosis of leptospirosis in a patient within 6 days of symptoms in whom serology is still negative. You can read more of leptospirosis and this case report of our fellow Dr MJ Kim here: https://t.co/87Xl7HKObV
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Publication Alert Antimicrobial susceptibility profiles of non-diphtheriae Corynebacterium species Congratulations Drs. @RyanKhodadadiMD @SaidElZein2 @omarabusaleh15 @stevens_AK @madihafidaMD @schuetz_audrey and team! https://t.co/fkis9hwQGU