Systemic autoinflammatory diseases encompass a growing number of rare conditions, with prevalence ranging from 1 in 1000 to 1 in 1,000,000 people, depending on the specific disease, country, and population (Krainer et al., 2020). Autoinflammatory diseases are caused by overactivation of innate immune responses. This overdrive of pro-inflammatory responses results in varied symptoms, including fever, rash, arthritis and, in some cases, a serious build-up of protein in organs, which is associated with amyloidosis. These manifestations usually develop in childhood and, in many cases, delayed diagnosis and/or a lack of treatment options makes these conditions chronic, with a staggering impact on quality of life.Ian Stedman is a strong advocate for people living with autoinflammatory diseases, having co-founded the Canadian Autoinflammatory Network (Réseau Auto-inflammatoire Canadien; Box 1) and acting as board chair for the Canadian Systemic Autoinflammatory Patient Advisory Group (Box 1)