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Mashup Score: 4Causal effect of life-course adiposity on the risk of respiratory diseases: a Mendelian randomization study - Nutrition & Metabolism - 16 day(s) ago
Background There is limited evidence on the causal associations of life-course adiposity with the risk of respiratory diseases. This study aimed to elucidate these associations. Methods Two-sample Mendelian randomization was conducted using genetic instruments of life-course adiposity (including birth weight, childhood BMI, and adulthood adiposity) to estimate their causal effect on respiratory diseases in participants of European ancestry from the UK Biobank, the FinnGen consortium, and other large consortia. Results Genetically predicted higher birth weight was associated with decreased risk of acute upper respiratory infections and increased risk of pulmonary embolism, sleep apnea, and lung cancer. Genetically predicted high childhood BMI was associated with increased risk of asthma, COPD, pulmonary embolism, and sleep apnea. However, most of these observed associations were no longer significant after adjusting for adult BMI. Genetically predicted higher adult BMI and WHR were asso
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Mashup Score: 1The effect of intensive resistance exercise and excessive fructose intake on metabolic and physiological responses - Nutrition & Metabolism - 1 month(s) ago
Background Muscle-derived uric acid (UA) precursors combined with fructose ingestion may increase liver UA production. Temporary hyperuricemia could impact metabolic and physiological responses over a 24-h period. This study examined the effects of intensive resistance exercise (RE) combined with excessive fructose intake on metabolic and physiological responses. Methods Twelve healthy young males participated in four trials: RE with fructose intake (EF), RE with water intake (EW), control (no exercise) with fructose intake (CF), and control with water intake (CW). Blood UA, glucose, lipids, blood pressure, and markers of kidney and liver function were measured during fasting and at 0, 0.5, 1, 2, 4, and 24 h before and after exercise. Results UA levels in the EF and EW trials were significantly higher than those in the CF and CW trials at all post-exercise time points. The next morning, UA levels in the EF trial remained above 7 mg/dL. Increased glucose levels at 0 and 0.5 h post-exerc
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Intensive resistance exercise combined with excessive fructose intake induces a notable increase in uric acid levels which is associated with temporary fluctuations in markers related to renal function, reports a study published in Nutrition & Metabolism. https://t.co/aQJGUtFxUv
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Mashup Score: 4Causal effect of life-course adiposity on the risk of respiratory diseases: a Mendelian randomization study - Nutrition & Metabolism - 2 month(s) ago
Background There is limited evidence on the causal associations of life-course adiposity with the risk of respiratory diseases. This study aimed to elucidate these associations. Methods Two-sample Mendelian randomization was conducted using genetic instruments of life-course adiposity (including birth weight, childhood BMI, and adulthood adiposity) to estimate their causal effect on respiratory diseases in participants of European ancestry from the UK Biobank, the FinnGen consortium, and other large consortia. Results Genetically predicted higher birth weight was associated with decreased risk of acute upper respiratory infections and increased risk of pulmonary embolism, sleep apnea, and lung cancer. Genetically predicted high childhood BMI was associated with increased risk of asthma, COPD, pulmonary embolism, and sleep apnea. However, most of these observed associations were no longer significant after adjusting for adult BMI. Genetically predicted higher adult BMI and WHR were asso
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A study published in Nutrition & Metabolism provides genetic evidence that greater adiposity in childhood and adulthood has a causal effect in increasing the risk of a wide range of respiratory diseases. https://t.co/bFjzipaYEi
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Mashup Score: 0Anti-inflammatory diets might mitigate the association between sedentary behaviors and the risk of all-cause deaths - Nutrition & Metabolism - 4 month(s) ago
Background and aims The pathogenic mechanism of sedentary behavior involves chronic inflammation, which can be affected by dietary inflammation. This study aimed to determine the association between dietary inflammation, sedentary behavior, and risk of death. Methods Data from the National Health and Nutrition Examination Survey (2007–2018) were analyzed. Sedentary behavior was evaluated using self-reported sitting hours in a day, and dietary inflammation was assessed using dietary inflammatory index (DII). Deaths were ascertained through the National Death Index until December 31, 2019. The interaction between dietary inflammation and sedentary behavior was evaluated through multivariable Cox regression analysis. Results 18,425 participants (mean age: 48.2 years; female proportion, 51.7%) were involved for analysis. During a median follow-up of 7.7 years, we confirmed 1,960 all-cause and 488 cardiovascular deaths. After adjustment for confounders, both pro-inflammatory diets and sitti
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Anti-inflammatory diets might mitigate the detrimental effects of sedentary behavior on survival in US adults, reports a study published in Nutrition & Metabolism. https://t.co/jAMkJRMmFB
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Mashup Score: 0
Background Intermittent fasting (IF) can be an effective dietary therapy for weight loss and improving cardiometabolic health. However, there is scant evidence regarding the role of IF on indicators of liver function, particularly in adults with metabolic disorders. Therefore, we performed a systematic review and meta-analysis to investigate the effects of IF on liver function in adults with metabolic disorders. Methods Three primary electronic databases including PubMed, Web of Science, and Scopus, were searched from inception to September 2024 to identify original studies that used IF interventions with or without control groups in adults with metabolic disorders. Inclusion criteria were (1) studies of human participants with metabolic diseases, (2) interventions that evaluated the effects of IF, (3) with or without a control group, and (4) measured liver fat, liver steatosis, liver fibrosis, or liver enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (A
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A systematic review and meta-analysis published in Nutrition & Metabolism finds that intermittent fasting may be an effective dietary therapy for improving liver function in adults with metabolic disorders. https://t.co/NJv8GQKepQ
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Mashup Score: 1Ultra-processed food intake in relation to metabolic health status in Iranian adolescents with overweight and obesity - Nutrition & Metabolism - 6 month(s) ago
Background Many studies have explored the association between food intake and metabolic health. However, research on the association of consuming ultra-processed foods (UPFs) and metabolic health in children and adolescents remains unclear. The objective of our study was to investigate the relation between UPFs consumption and metabolic health status in Iranian adolescents with overweight/obesity. Methods For this cross-sectional study, we selected a sample of 203 adolescents (101 boys and 102 girls) with a mean age of 13.98 ± 1.61 who were chosen using a multistage cluster random sampling method. We collected data on their dietary patterns using a validated 147-item semi-quantitative food frequency questionnaire. Additionally, we measured anthropometric indices, blood pressure, fasting glucose, insulin, and lipid profiles. Participants were categorized to either metabolically healthy or unhealthy overweight/obesity (MHO and MUO) based on the International Diabetes Federation (IDF) and
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Ultra-processed food intake in relation to metabolic health status in Iranian adolescents with overweight and obesity | Nutrition & Metabolism https://t.co/HwgZIpnlJn
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Mashup Score: 5
Background Research has demonstrated that obesity may be associated with rheumatoid arthritis (RA). In addition, Dysbiosis of intestinal microbiota and their metabolites has been linked to the occurrence and development of RA and obesity. However, the mechanism by which obesity affects RA remains unclear.In this study, we explored the impact of high fat diet(HFD) on collagen-induced arthritis (CIA) rats and revealed its mechanisms based on gut microbiota and metabolomics. Methods Based on diet and modeling, rats were divided into normal group (Con), CIA model group, HFD group (HFD), and HFD + CIA group (HCIA). The effect of HFD on arthritis in CIA rats were investigated based on the arthritis index (AI), weight, blood lipid levels, and inflammatory cytokines. Moreover, HE staining and micro-CT were performed to evaluated the effect of HFD on the pathology of joints and synovial tissues in CIA rats.16S rRNA amplicon sequencing and liquid chromatography-mass spectrometry (LC–MS) were emp
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High-fat diet stimulated butyric acid metabolism dysbiosis, altered microbiota, and aggravated inflammatory response in collagen-induced arthritis rats | Nutrition & Metabolism | Full Text https://t.co/Y1ABy3IGFb
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Mashup Score: 2
Background The relationship between free fatty acids (FFAs) and the risk of mortality remains unclear. There is a scarcity of prospective studies examining the associations between specific FFAs, rather than total concentrations, of their effect on long-term health outcomes. Objective To evaluate the correlation between different FFAs and all-cause and cardiovascular mortality in a large, diverse, nationally representative sample of adults in the US, and examine how different FFAs may mediate this association. Methods This cohort study included unsaturated fatty acids (USFA) and saturated fatty acids (SFA) groups in the US National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014 and provided blood samples for FFAs levels. Multiple model calibration was performed using Cox regression analysis for known risk factors to explore the associations between FFAs and all-cause and cardiovascular mortality. Results In the group of USFA, 3719 people were included, median follow
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A study published in Nutrition & Metabolism highlights the influence of various circulating free fatty acids on all-cause and cardiovascular mortality. https://t.co/pJKTiHois7
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Mashup Score: 2Impact of vitamins A, D, and homocysteine on cardiometabolic multimorbidity in Northwest China - Nutrition & Metabolism - 10 month(s) ago
Objective To investigate the impact of vitamin A (VA), vitamin D (VD), and homocysteine (Hcy) on cardiometabolic multimorbidity (CMM). Methods This study is a cross-sectional study conducted in Ningxia Province, China. A total of 5000 participants aged 25–74 were recruited and divided into two groups based on the definition of cardiometabolic multimorbidity: the CMM group and the Non CMM group. Demographic, lifestyle, and laboratory data were collected to investigate the correlation between vitamin A, D, Hcy levels and CMM risk. The association was analyzed using multiple logistic regression and restricted cubic spline method. Results CMM incidence increased with age, being higher in females (20.05%) compared to males, Hypertension was present in 96.20% of CMM cases. Reduced VD levels correlated with an elevated CMM risk (OR = 1.799, 95% CI: 1.466–2.238), showing an inverse dose-response relationship, even after adjusting for confounders (OR = 1.553, 95% CI: 1.233–1.956). However, VA a
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A study published in Nutrition & Metabolism finds that lower serum vitamin D levels correlate with greater cardiometabolic multimorbidity risk. https://t.co/OeSkp35Uxh
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Mashup Score: 3Effects of cheese ingestion on muscle mass and strength in possible sarcopenia women: an open-label, parallel-group study - Nutrition & Metabolism - 10 month(s) ago
Background Nutrient-rich cheese supplements were demonstrated to have improvements in markers of sarcopenia in healthy elders. However, the potential effects of cheese in individuals with possible sarcopenia remain unknown. Method This 90-day randomized controlled trial (RCT) included 68 women aged 60–80 years with possible sarcopenia in China, who were randomly assigned to three groups: Control group (CG), Original cheese group (OG: 9.0 g protein; 322.8 mg calcium), and Golden cheese group (GG: 12.7 g protein; 802.1 mg calcium). OG and GG were instructed to consume their habitual diet along with 4 slices of supplied cheese, while CG was directed to maintain their usual dietary habits. Face-to-face interviews, anthropometric measurements, and blood sample collection were conducted at baseline, midway (60 days), and the end of the trial. Result At the end of the trial, the primary outcome, changes of Skeletal Muscle Mass Index (SMI) were found to be higher in OG (0.18 ± 0.02 kg/m2) and
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A study published in Nutrition & Metabolism finds that consuming four slices of cheese within the context of habitual diets is effective for improving muscle strength and mass in 60 to 80-year-old women with possible sarcopenia. https://t.co/6LHSVSbLZF
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A study published in Nutrition & Metabolism provides genetic evidence that greater adiposity in childhood and adulthood has a causal effect in increasing the risk of a wide range of respiratory diseases. https://t.co/bFjzipaYEi