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Mashup Score: 2Association between sleep and gallstone disease in United States adults: A cross-sectional study - BMC Public Health - 2 hour(s) ago
Background Both gallstone disease and sleep disorders are important public health problems. Few studies to date have investigated the associations between sleep and gallstone disease in humans. This study aimed to assess whether sleep factors (sleep time, sleep amounts, trouble sleeping) were associated with gallstone disease in the United States adults. Methods This was a population-based cross-sectional study of US adults, which included data of participants aged over 20 years from the National Health and Nutrition Examination Survey (NHANES) gathered between 2017 and March 2020. The assessment of gallstone disease and sleep factors was based on self-reported data. We used sample-weighted logistic regression and restricted cubic spline models to explore the associations between sleep factors and gallstone disease. Subgroup analyses were conducted to assess the interaction between trouble sleeping and interacting factors. Results The prevalence of gallstone disease was 11% among the 9
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Mashup Score: 5Quantifying the association between PM2.5 air pollution and IQ loss in children: a systematic review and meta-analysis - Environmental Health - 3 hour(s) ago
Background A growing body of epidemiologic and toxicologic literature indicates that fine airborne particulate matter (PM2.5) pollution is neurotoxic and threatens children’s neurobehavioral development, resulting in reduced cognitive function. Understanding the magnitude of this effect is critical for establishing public health policies that will protect children’s health, preserve human capital, and support societal progress. Objective To quantify the association between ambient PM2.5 air pollution and loss of cognitive function in children, as measured by Intelligence Quotient (IQ) scores, through a systematic literature review and meta-analysis. Methods Following PRISMA guidelines, we conducted a systematic literature search across seven databases: Agricultural and Environmental Science, BIOSIS Citation Index, Embase, GreenFILE, PubMed, Scopus, and Web of Science to identify original scientific studies that investigated the impact of PM2.5 exposure during pre-and postnatal periods
Source: ehjournal.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A systematic review and meta-analysis published in Environmental Health finds a significant relationship between increased exposure to particulate matter air pollution and reduced cognitive function in children, with more impact on performance IQ. https://t.co/C6O5QqM4iZ
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Mashup Score: 1Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes - Cardiovascular Diabetology - 10 hour(s) ago
Background Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophysiology, and serving as predictive markers in clinical practice. Urine is less tightly regulated than blood, and therefore, may enable earlier discovery of disease-associated markers. We studied urine metabolomics in relation to incident CAD in individuals with type 1 diabetes. Methods We prospectively studied CAD in 2501 adults with type 1 diabetes from the Finnish Diabetic Nephropathy Study. 209 participants experienced incident CAD within the 10-year follow-up. We analyzed the baseline urine samples with a high-throughput targeted urine metabolomics platform, which yielded 54 metabolites. With the data, we performed metabolome-wide survival analyses, correlation network analyses, and metabolomic state profiling for prediction of incident CAD. Results Urinary 3-hydroxy
Source: cardiab.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study published in Cardiovascular Diabetology demonstrates that urinary metabolites may be utilized for coronary artery disease prediction in type 1 diabetes. https://t.co/Eygc3ZAHbP
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Mashup Score: 1
Background The World Health Organization (WHO) declared the end of the COVID-19 (SARS-CoV-2) global public health emergency on May 5, 2023, but its long-term consequences have still been haunting the global population. Post-acute sequelae of COVID-19 (PASC) and long-term COVID-19 are serious concerns and present with various symptoms. Intranasal chlorpheniramine (iCPM) has been shown to decrease the viral burden of SARS-COV-2. iCPM uses decreased COVID-19 disease progression and severity in Accelerating COVID-19 Clinical Recovery in an Outpatient Setting (ACROSS)-I & III randomized control trials (RCT). Methods This prospective survey study included 259 participants in ACROSS I and III RCTs. We compared the effect of iCPM versus placebo on the reduction of PASC symptoms. A PASC questionnaire containing 17 questions regarding the most common PASC symptoms was used in this study. T-test and Pearson chi-square statistics were performed according to continuous and categorical data using ST
Source: bmcinfectdis.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study published in #BMCInfectDis finds that the use of intranasal chlorpheniramine shows promise in preventing COVID-19 progression to the often-debilitating post-acute sequelae of SARS-CoV-2 infection. https://t.co/6PryXjCbYk
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Mashup Score: 2
Background Hip fractures are a major health concern for older adults, often leading to reduced walking ability. Individuals with dementia may experience worse recovery outcomes. This study aims to explore whether dementia is associated with greater declines in walking ability following hip fractures. Methods This register study used data from the Swedish Hip Fracture Register, including data on four-months follow-up on walking ability. The register data was linked to information on dementia diagnosis from other national registers prior to the fracture. All patients > 60 years who suffered a hip fracture in Sweden between 2010 and 2018 were included. Binary logistic regression was used to analyze the loss of walking ability after the hip fracture with adjustment for confounding factors. Stratified analyses were done in four groups based on pre-fracture walking ability: Alone outdoors, Assisted outdoors, Alone indoors, and Assisted indoors. Results The analysis included 59,402 patients w
Source: bmcgeriatr.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A study published in #BMCGeriatr reports that patients with dementia are significantly more likely to experience a decline in walking ability after a hip fracture, especially those with high pre-fracture mobility. https://t.co/bEhetoEg2Q
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Mashup Score: 7Sex-specific dietary habits and their association with weight change in healthy adults - BMC Medicine - 1 day(s) ago
Background Dietary intake plays a pivotal role in the prevalence and management of obesity. While women and men exhibit differences in dietary habits and food-related behaviors, sex-based weight loss recommendations are lacking. This study aims to examine the impact of specific foods and food categories on weight reduction in men and women over a two-year period. Methods A total of 8,548 participants from the 10K cohort, from 2019 to 2023, were included in the analysis (53.1% women, mean age 51.7 years). Anthropometric measurements and laboratory results were collected at baseline and at the two-year follow-up visit. Dietary assessment was based on daily food intake digitally logged through an application for at least 3 consecutive days at both timepoints. We compared intake of macronutrients, micronutrients, food groups and daily energy consumption between sex and body mass index (BMI) categories at baseline and weight change categories at follow-up. Using linear regression, we assess
Source: bmcmedicine.biomedcentral.comCategories: General Medicine News, General Journals & SocietTweet-
A study published in @BMCMedicine finds that in men, weight loss is primarily associated with the addition of animal-based protein, while in women, it is linked to caloric deficit and plant-based fat. https://t.co/sbugTuEV8r
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Mashup Score: 7World AIDS Day 2024 - 1 day(s) ago
We are commemorating World AIDS Day by sharing a selection of blogs about HIV and AIDS written by researchers across the world.
Source: communities.springernature.comCategories: General Medicine News, General HCPsTweet-
On the occasion of #WorldAIDSDay, we are sharing blogs about HIV and AIDS written by researchers across the world. These blogs support Sustainable Development Goal 3: Good Health and Wellbeing. #SDG3 #AIDS #HIV Read more here: https://t.co/My22A5nCFC
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Mashup Score: 2
Background The use of inhaled antibiotics for treating pneumonia in invasively ventilated patients offers a direct approach, allowing for high local concentrations of the drug in the lower respiratory tract while simultaneously reducing systemic toxicity. However, the real efficacy and safety of nebulized antibiotics remain unclear. The aim of the present is to assess among critically adult patients with pneumonia and invasive ventilation, whether receiving adjuvant inhaled antibiotics improves the rate of microbiological eradication. Methods A comprehensive literature search of randomized clinical trials (RCTs) was conducted (from inception until September 20, 2024, PROSPERO-CRD592906) across Medline, Embase, and Scopus. Randomized controlled trials, enrolling intensive care units (ICU) patients with pneumonia and comparing nebulized antimicrobial therapy (inhaled group) with intravenous antimicrobial treatment or intravenous antimicrobial therapy plus inhaled placebo (control group),
Source: ccforum.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A Review in @Crit_Care finds that compared to sole intravenous therapy, using adjuvant inhaled antibiotics for treatment of pneumonia in invasively ventilated critically ill patients is associated with a greater incidence of microbiological eradication. https://t.co/vgZwSE208K https://t.co/lfI9sU6krX
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Mashup Score: 1
Background Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be examined in detail. This study aimed to investigate the hypothesis that the social content of stimuli could play a specific role in some of the flexibility challenges faced by autistic individuals. The second aim was to explore sex differences in this context. Methods We analyzed data from 256 adult participants (124 with autism), matched on age, gender, and sex, who performed an emotional shifting task involving unpredictable shifts between positive and negative stimuli. Additionally, the task included both social and non-social conditions. Results Our results revealed a larger switch cost in the social than in the non-social condition, and this was more pronounced in autistic than in non-autistic individuals. Furthermore, we observed that autistic females differed fr
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A study published in Molecular Autism highlights that the social context, rather than the emotional nature of the stimuli alone, may play a significant role in the flexibility challenges faced by autistic individuals. https://t.co/F6TRNKbbCD
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Mashup Score: 5
Objective There has been conflicting evidence in earlier research on the association between parental age and autism risk. To clarify this association, we conducted a comprehensive meta-analysis of observational studies. The primary objective of this study was to determine the association between parents’ age and the risk of autism in the offspring. Methods PubMed, EMBASE and Web of Science were searched for reports published up to November 2023. Results from relevant studies were pooled using random effects models. Subgroup analyses and meta-regression were performed to examine heterogeneity between the studies. Studies were included in this meta-analysis that focused on children with autism and examined the relationship between parents’ age (mother or father) and the risk of autism.The quality of studies was assessed using the Newcastle–Ottawa Scale (NOS). Results This meta-analysis included 41 articles. The low age of mother (OR = 0.96, (95% CIs: 0.88–1.05) and father (OR = 1.11, (9
Source: bmcpsychology.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
Increased risk of autism in children is significantly associated with greater parents' ages, reports a systematic review and meta-analysis published in #BMCPsychology https://t.co/HPKiI3JbO7
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A study published in #BMCPublicHealth reports that going to bed late, short sleep duration, and trouble sleeping are associated with increased risk of gallstone disease among U.S. adults. https://t.co/dCPhKBEWoF