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Mashup Score: 7Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma - PubMed - 5 hour(s) ago
B-cell maturation antigen (BCMA)-targeting therapeutics have dramatically improved outcomes in relapsed/refractory multiple myeloma (RRMM). However, whether the mechanisms of resistance between these therapies are shared and how the identification of such mechanisms before therapy initiation could r …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma - PubMed - 8 hour(s) ago
B-cell maturation antigen (BCMA)-targeting therapeutics have dramatically improved outcomes in relapsed/refractory multiple myeloma (RRMM). However, whether the mechanisms of resistance between these therapies are shared and how the identification of such mechanisms before therapy initiation could r …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Consequences of excess iodine - PubMed - 8 hour(s) ago
Iodine is a micronutrient that is essential for the production of thyroid hormones. The primary source of iodine is the diet via consumption of foods that have been fortified with iodine, including salt, dairy products and bread, or that are naturally abundant in the micronutrient, such as seafood. …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Iodine kinetics and effectiveness of stable iodine prophylaxis after intake of radioactive iodine: a review - PubMed - 8 hour(s) ago
Ingestion of potassium iodide (KI) offers effective protection against irradiation of the thyroid after accidental exposure to radioactive iodine. This prophylaxis aims at rapidly obtaining maximal thyroid protection without adverse effects. This article reviews studies on iodine kinetics in humans …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
Plasma inorganic iodide as a homeostatic regulator of thyroid function
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2
In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodid …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1The sodium/iodide symporter: state of the art of its molecular characterization - PubMed - 8 hour(s) ago
The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and thyroid regulation and its function is widely exploited in the diagnosis and treatment of benign and malignant thyr …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
Iodine is a vital micronutrient required at all stages of life; fetal life and early childhood being the most critical phases of requirement. Diet is the sole source of iodine, which in turn is dependent upon the iodine content of water and soil. Iodine is metabolized in the human body through a ser …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Potassium iodide for thyroid blockade in a reactor accident: administrative policies that govern its use - PubMed - 8 hour(s) ago
A marked increase in thyroid cancer among young children who were in the vicinity of the Chernobyl nuclear power plant at the time of the 1986 accident strongly suggests a possible causal relationship to the large amounts of radioactive iodine isotopes in the resulting fallout. Although remaining in …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
7/ One of the first public health responses was to distribute potassium iodide pills/solutions to people in surrounding areas, w/ the goal of preventing thyroid cancers. Poland, for example, distributed 18 million iodine doses to its at-risk population. https://t.co/CU6qVlwhzu https://t.co/da6mBPlRXq
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Mashup Score: 25Mitral Annular Disjunction and Its Progression during Childhood in Marfan Syndrome - PubMed - 18 hour(s) ago
MAD was common in pediatric MFS and was associated with aortic root dilation. MAD detection by echocardiography and CMR was highly reliable, suggesting that routine assessment in MFS is feasible. MAD was present in neonates and progressed over time but remained constant when indexing by height. Furt …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Cardiologists1Tweet
#Myeloma Paper of the Day: Loss of BCMA expression following TNFRSF17 gene deletions is rare but can occur after any BCMA-directed therapy & prevents response to subsequent anti-BCMA-directed treatments: https://t.co/SjUtUkR05E. #mmsm https://t.co/QY7c95Nxeq