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Mashup Score: 15Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence - 13 hour(s) ago
Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, and increasing industrial production have led to questions about their long-term impact on human and animal health. This narrative review describes the effects of MNPs on oxidative stress, inflammation, and aging. Exposure to MNPs leads to increased production of reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, and animal systems. ROS can cause damage to cellular macromolecules such as DNA, proteins, and lipids. Direct interaction between MNPs and immune cells or an indirect result of oxidative stress-mediated cellular damage may lead to increased production of pro-inflammatory cytokines throughout different MNP-exposure conditions. This inflammatory response is a common feature in the pathogenesis of neurodegenerative, cardiovascular, and other age-related diseases. MNPs also act as cell senescence inducers by promoting mito
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Mashup Score: 11Anti-Inflammatory Diet and Protein-Enriched Diet Can Reduce the Risk of Cognitive Impairment among Older Adults: A Nationwide Cross-Sectional Research - 18 hour(s) ago
Background: Cognitive impairment (CI) is a common mental health disorder among older adults, and dietary patterns have an impact on cognitive function. However, no systematic researches have constructed anti-inflammatory diet (AID) and protein-enriched diet (PED) to explore their association with CI among older adults in China. Methods: The data used in this study were obtained from the 2018 waves of the China Longitudinal Health and Longevity Survey (CLHLS). We construct AID, PED, and calculate scores for CI. We use binary logistic regression to explore the relationship between them, and use restrictive cubic splines to determine whether the relationships are non-linear. Subgroup analysis and sensitivity analysis were used to demonstrate the robustness of the results. Results: A total of 8692 participants (mean age is 83.53 years) were included in the analysis. We found that participants with a higher AID (OR = 0.789, 95% confidence interval: 0.740–0.842, p < 0.001) and PED (OR = 0.91
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Higher intake of anti #inflammation diet and protein-enriched diet are associated with a lower risk of cognitive 🧠impairment among older adults in China, there is a linear relationship between them. https://t.co/z7ZeD3l1EK https://t.co/tnO99gAiEe
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Mashup Score: 9Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis - 3 day(s) ago
Background/Objectives: Antibody light chains form amyloid fibrils that lead to progressive tissue damage in amyloid light chain (AL) amyloidosis. The properties of each patient’s unique light chain appear to determine its propensity to form amyloid. One factor is N-glycosylation, which is more frequent in amyloid-associated light chains than in light chains from the normal immune repertoire. However, the mechanisms underlying this association are unknown. Here, we investigate the frequency and position within the light chain sequence of the N-glycosylation sequence motif, or sequon. Methods: Monoclonal light chains from AL amyloidosis and multiple myeloma were identified from the AL-Base repository. Polyclonal light chains were obtained from the Observed Antibody Space resource. We compared the fraction of light chains from each group harboring an N-glycosylation sequon, and the positions of these sequons within the sequences. Results: Sequons are enriched among AL-associated light cha
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No clear structural rationale for why N-glycosylation of Îş light chains is associated with AL amyloidosis. @BU_Amyloidosis Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis https://t.co/OVgEk0NZyl https://t.co/HweiyNhEC6
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Mashup Score: 26Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer - 3 day(s) ago
Background/Objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer. Methods: Toxicity was scored via the CTCAE v5.0, and outcomes estimated using the Kaplan–Meier method, with associations evaluated via Cox proportional hazards and logistic regression analyses. Results: Patients were treated to a median re-RT prescription of 66 Gy/33 fxs (BED10 = 79 Gy; IQR: 71–84 Gy) at an interval of 1.4 years from prior RT. Half (50%) received concurrent chemotherapy. At 14 months follow-up, the median OS and PFS were 5 months (95%CI: 13–17) and 12.5 months (95%CI: 10–15), respectively. On multivariable analysis, a higher RT dose (BED10 > 70 Gy) [HR0.37; 95%CI: 0.20–0.68, p = 0.001] and concurrent chemotherapy (HR0.48; 95%CI: 0.28–0.81, p = 0.007) were associated with improved PFS, while treatment site overlap was adversely associated (HR1.78; 95%CI: 1.05–3.02, p = 0.031). The m
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Great collaboration with former colleagues, led by Matt Ning on @MDAndersonNews thoracic proton re-irradiation outcomes: pt selection, higher BED, concurrent chemotherapy, reduced prior RT dose overlap correlated with improved survival and safety. ⬇️ https://t.co/QM9nj4f6yj https://t.co/E8RUPHktAk
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Mashup Score: 9
One of the most common diseases afflicting humans is knee osteoarthritis (KOA). KOA occurs when the knee joint cartilage breaks down, and knee bones start rubbing together. The diagnosis of KOA is a lengthy process, and missed diagnosis can have serious consequences. Therefore, the diagnosis of KOA at an initial stage is crucial which prevents the patients from Severe complications. KOA identification using deep learning (DL) algorithms has gained popularity during the past few years. By applying knee X-ray images and the Kellgren–Lawrence (KL) grading system, the objective of this study was to develop a DL model for detecting KOA. This study proposes a novel model based on CNN called knee osteoarthritis classification network (KOC_Net). The KOC_Net model contains 05 convolutional blocks, and each convolutional block has three components such as Convlotuioanl2D, ReLU, and MaxPooling 2D. The KOC_Net model is evaluated on two publicly available benchmark datasets which consist of X-ray i
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Impact of the Synthetic Minority Over-Sampling Technique with Deep Learning Models for Classification of Knee Osteoarthritis Using Kellgren–Lawrence X-Ray Grade https://t.co/da1ZzYAfDF
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Mashup Score: 95Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment - 8 day(s) ago
Salivary gland tumors are neoplasms affecting the major and minor salivary glands of the oral cavity. Their complex pathological appearance and overlapping morphological features between subtypes, pose major challenges in the identification, classification, and staging of the tumor. Recently developed techniques of three-dimensional culture and organotypic modelling provide useful platforms for the clinical and biological characterization of these malignancies. Additionally, new advances in genetic and molecular screenings allow precise diagnosis and monitoring of tumor progression. Finally, novel therapeutic tools with increased efficiency and accuracy are emerging. In this review, we summarize the most common salivary gland neoplasms and provide an overview of the state-of-the-art tools to model, diagnose, and treat salivary gland tumors.
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RT @thejourneymate: Schematic Representation of Hallmarks in Malignant Salivary Gland Tumors 🔬 https://t.co/di6JjdzsDI https://t.co/eYwVB23…
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Mashup Score: 74Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review - 8 day(s) ago
Background: Anti-phospholipid syndrome (APS) has emerged as a significant issue in autoimmune diseases over recent decades. Its hallmark feature is thromboembolic events, potentially affecting any vascularized area including the microcirculation of the inner ear. Since the first case report of APS-related audiovestibular dysfunction described in 1993, numerous reports have explored the association between APS-related antibodies and audiovestibular dysfunction. These studies indicate a higher prevalence of APS-related antibodies in patients with sensorineural hearing loss compared to healthy controls. Unlike other idiopathic hearing loss disorders, audiovestibular dysfunction associated with APS may respond to appropriate treatments, highlighting the importance of timely recognition by clinicians to potentially achieve favorable outcomes. Therefore, this systematic review aims to consolidate current evidence on the characteristics, pathophysiology, assessment, and management of audioves
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Systematic review suggests (although not provn) that audiovestibular dysfunction may be from APS. Anti-phospholipid & HSP-70 Abs found 25-33% w/idiopathic sudden sensorineural hearing loss,. ACL Abs seen in up to 27% w/ sensorineural hearing loss https://t.co/WcmeCP0ryq https://t.co/DiYX57R0uG
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Mashup Score: 94Cytomegalovirus Infection After Solid Organ Transplantation: How I Use Cell-Mediated Immune Assays for Management - 10 day(s) ago
Introduction: The pathogenesis and outcome of cytomegalovirus (CMV) infection after solid organ transplantation (SOT) reflects the interplay between viral replication and CMV-specific immunity. Despite advances in its diagnosis and treatment, CMV continues to cause significant morbidity after SOT. Since CMV is an opportunistic pathogen that occurs as a result of impaired pathogen-specific immunity, laboratory assays that measure CMV-specific immune responses may be useful in assisting clinicians in its management. Methods and Results: The author summarizes the evolving and emerging data on the clinical utility of assays that quantify cell-mediated immune responses to CMV in SOT recipients. The majority of publications are observational studies that demonstrate that a lack or deficiency in CMV-specific cell-mediated immunity is correlated with a heightened risk of primary, reactivation, or recurrent CMV after transplantation. A few prospective interventional studies have utilized CMV-sp
Source: www.mdpi.comCategories: General Medicine News, Infectious DiseaseTweet-
Cytomegalovirus Infection After Solid Organ Transplantation: How I Use Cell-Mediated Immune Assays for Management https://t.co/oQwB4YKdAN #mdpiviruses via @VirusesMDPI
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Mashup Score: 3Effect of Glucagon-like Peptide-1 Receptor Agonism on Aortic Valve Stenosis Risk: A Mendelian Randomization Analysis - 10 day(s) ago
Background: Aortic valve repair is currently the only effective treatment for calcific aortic valve stenosis (CAVS), as no pharmacological therapies exist to prevent or slow its progression. Recent promising results showed that glucagon-like peptide-1 (GLP-1) attenuates the calcification of aortic valve interstitial cells. Therefore, we conducted a two-sample Mendelian randomization analysis to investigate the effect of GLP-1 receptor agonism (GLP-1Ra) on the risk of CAVS. Methods: The inverse variance weighted (IVW) method was used to obtain the primary causal inference, and several sensitivity analyses, including MR-Egger, were performed to assess the robustness of the results. Results: Based on the IVW estimates, the GLP-1Ra showed a neutral effect on the risk of CAVS (odds ratio [OR] per 1 mmol/mol decrease in glycated hemoglobin = 0.87, 95% CI = [0.69, 1.11], p = 0.259; I2 = 4.5%, Cohran’s Q = 2.09, heterogeneity p = 0.35; F statistic = 16.8). A non-significant effect was also der
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
Effect of Glucagon-like Peptide-1 Receptor Agonism on Aortic Valve Stenosis Risk: A Mendelian Randomization Analysis, by Karakasis et al https://t.co/QKpTq9zje9 https://t.co/yzqkLH1851
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Mashup Score: 5Finerenone: A Third-Generation MRA and Its Impact on Cardiovascular Health—Insights from Randomized Controlled Trials - 10 day(s) ago
Introduction: Finerenone, a third-generation non-steroidal mineralocorticoid receptor antagonist (MRA), offers a targeted approach to managing cardiovascular outcomes, particularly in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). Unlike traditional MRAs such as spironolactone and eplerenone, which can cause off-target hormonal side effects and hyperkalemia, Finerenone selectively binds to mineralocorticoid receptors, reducing these risks. Recent randomized controlled trials have demonstrated Finerenone’s potential to improve cardiovascular outcomes, making it a promising alternative in the management of heart failure and other cardiovascular conditions associated with CKD and T2D. Methods: We conducted a scoping review using PRISMA guidelines. A search for “Finerenone” in the PubMed, Embase, and Cochrane Library databases included randomized controlled trials (RCTs), post hoc analyses, and relevant meta-analyses on cardiovascular outcomes. Data were synthesized
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
https://t.co/CfxqtyVG4R
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Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence https://t.co/QfiHOEBKYf