-
Mashup Score: 16
Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 19
A new method can now find previously unknown factors that underlie disease by using statistical machine learning to sort through mountains of complex biological data.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 19Gene discovered that can protect against severe muscle disease - 2 month(s) ago
A specific gene may play a key role in new treatments that prevent muscle in the body from breaking down in serious muscle diseases, or muscular dystrophies. This is shown in a new study carried out at …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 9Q&A: How a potential treatment for Alzheimer's disease could also work for type 2 diabetes - 2 month(s) ago
Of the 38 million Americans who have diabetes, at least 90% have type 2, according to the Centers for Disease Control and Prevention. Type 2 diabetes occurs over time and is characterized by a loss of …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 17Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6 - 4 month(s) ago
Changes in the intracellular trafficking of key signaling molecules in endosomes lead to pathophysiology in a rare disease affecting the cerebellum.
Source: elifesciences.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 34Different biological variants discovered in Alzheimer's disease - 4 month(s) ago
Dutch scientists have discovered five biological variants of Alzheimer’s disease, which may require different treatments. As a result, previously tested drugs may incorrectly appear to be ineffective …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 9
Background We interrogated auditory sensory memory capabilities in individuals with CLN3 disease (juvenile neuronal ceroid lipofuscinosis), specifically for the feature of “duration” processing. Given decrements in auditory processing abilities associated with later-stage CLN3 disease, we hypothesized that the duration-evoked mismatch negativity (MMN) of the event related potential (ERP) would be a marker of progressively atypical cortical processing in this population, with potential applicability as a brain-based biomarker in clinical trials. Methods We employed three stimulation rates (fast: 450 ms, medium: 900 ms, slow: 1800 ms), allowing for assessment of the sustainability of the auditory sensory memory trace. The robustness of MMN directly relates to the rate at which the regularly occurring stimulus stream is presented. As presentation rate slows, robustness of the sensory memory trace diminishes. By manipulating presentation rate, the strength of the sensory memory trace is pa
Categories: General Medicine News, General HCPsTweet
-
Mashup Score: 5Evidence for clinical interventions targeting the gut microbiome in cardiometabolic disease - 7 month(s) ago
Tarini Shankar Ghosh and Ana Maria Valdes evaluate the evidence for clinical effects of microbiome altering interventions on cardiometabolic traits ### Key messages Cardiometabolic diseases are one of the main causes of morbidity and mortality in western countries and are increasing in low and middle income countries.1 Dietary intake is one of the main determinants of cardiometabolic health1 and of microbiome composition.2 The gut microbiome is known to play an important part in the development of cardiometabolic diseases, including hypertension, diabetes, and obesity.2 This is thought to be linked with the ability of the gut microbiome to modulate inflammation, insulin sensitivity, and blood lipid levels, and is hypothesised to be mediated by specific microbially produced metabolites such as short chain fatty acids (SCFAs), secondary bile acids, phenylacetylglutamine, and trimethylamine-N-oxide.2 As well as their direct influence, gut microbes can also modulate the response of the hum
Source: www.bmj.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
-
Mashup Score: 6
Objective Polymorphisms in the antifungal signalling molecule CARD9 are associated with ankylosing spondylitis (AS). Here, we investigated the cellular mechanism by which CARD9 controls pathogenic Th17 responses and the onset of disease in both experimental murine AS and patients. Methods Experiments in SKG, Card9−/−SKG, neutrophil-deplete SKG mice along with in vitro murine, neutrophil and CD4+ T cell cocultures examined Card9 function in neutrophil activation, Th17 induction and arthritis in experimental AS. In AS patients the neutrophil: Bath Ankylosing Spondylitis Functional Index relationship was analysed. In vitro studies with autologous neutrophil: T cell cocultures examined endogenous CARD9 versus the AS-associated variant (rs4075515) of CARD9 in T cellular production of IL-17A. Results Card9 functioned downstream of Dectin-1 and was essential for induction of Th17 cells, arthritis and spondylitis in SKG mice. Card9 expression within T cells was dispensable for arthritis onset
Source: ard.bmj.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 0PNAS Nexus - 7 month(s) ago
PNAS Nexus is a broad, highly selective, open access journal with a focus on innovation and rapid publication. It publishes innovative and interdisciplinary research and perspectives from across the biological, physical, and social sciences.
Source: academic.oup.comCategories: General Medicine News, Latest HeadlinesTweet
Simulations reveal mechanism behind protein buildup in Parkinson's #disease @elife @elife https://t.co/mpzidXkd3a