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Mashup Score: 27Studying the intersection of obesity and pancreatic cancer to unlock early warning signs - 17 day(s) ago
A cancer researcher’s unique lab @OSUCCC_James is studying the intersection of obesity and pancreatic disease to improve outcomes for pancreatic cancer.
Source: health.osu.eduCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 70
Abstract. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with cancer associated fibroblasts (CAFs). This study utilized a convergence approach to identify tumor cell and CAF interactions through the integration of single-cell data from human tumors with human organoid co-culture experiments. Analysis of a comprehensive atlas of PDAC single-cell RNA sequencing (scRNA-seq) data indicated that CAF density is associated with increased inflammation and epithelial-mesenchymal transition (EMT) in epithelial cells. Transfer learning using transcriptional data from patient-derived organoid and CAF co-cultures provided in silico validation of CAF induction of inflammatory and EMT epithelial cell states. Further experimental validation in co-cultures demonstrated integrin beta 1 (ITGB1) and vascular endothelial factor A (VEGF-A) interactions with neuropilin-1 (NRP1) mediating CAF-epithelial cell crosstalk.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
A great example of the interdisciplinary science @ciacobu wants to see more of in @CR_AACR Transfer learning reveals cancer-associated fibroblasts are associated with epithelial-mesenchymal transition and inflammation in cancer cells in #PancreaticCancer https://t.co/ltahmwuv6F https://t.co/RNNQW5NejE
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Mashup Score: 16
A new type of investigational therapeutic in development for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the disease, suggesting it has the potential to …
Source: medicalxpress.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 58Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer - 22 day(s) ago
Niu et al. identify a lipid-laden CAF subset marked by ABCA8a in Setd2-deficient pancreatic tumors, which transports lipids and metabolically sustains tumor growth via OXPHOS. Both in vivo and ex vivo experiments reveal that tumor-intrinsic SETD2 loss induces epigenetic reprogramming and unleashes BMP signaling to foster the differentiation of lipid-laden CAFs.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells - 23 day(s) ago
In this study, Chang et al. provide mechanistic insights into how the Ube2f-CRL5Asb11 axis positively controls mouse pancreatic tumorigenesis induced by KrasG12D. CRL5ASB11, upon activation by UBE2F, promotes ubiquitylation and degradation of DIRAS2, leading to activation of the Mapk-c-Myc signals, thus serving as an attractive PDAC target.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia - BMC Cancer - 23 day(s) ago
Background Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The second is cachexia, which compromises treatment tolerance for patients and reduces their quality of life. Although various mouse models of PDAC exist, recapitulating both metastatic and cachectic features have been challenging. Methods Here, we optimize an orthotopic mouse model of PDAC by altering several conditions, including the subcloning of parental murine PDAC cells, implantation site, number of transplanted cells, and age of recipient mice. We perform spatial profiling to compare primary and metastatic immune microenvironments and RNA sequencing to gain insight into the mechanisms of muscle wasting in PDAC-induced cachexia, comparing non-metastatic to metastatic conditions. Results These modifications extend the time course of the disease and concurrently increas
Source: bmccancer.biomedcentral.comCategories: General Medicine News, Hem/OncsTweet-
From @DenisGuttridge @muschollings Optimization of a mouse model of #PancreaticCancer to simulate the human phenotypes of metastasis and cachexia https://t.co/yHpfsXOSIy The authors have re-derived a syngeneic murine KPC cell line (KPCML1) with consistent metastatic propensity… https://t.co/W4tMgmrLbk https://t.co/sinNLEgEj6
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Mashup Score: 15Improving the odds for patients with pancreatic cancer - 1 month(s) ago
Cancer surgeon and researcher @OSUCCC-James is studying the most difficult-to-treat cancers with a focus on improving the odds for patients with pancreatic cancer.
Source: health.osu.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 53Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer - 1 month(s) ago
Nature Communications – The MAPK pathway is an important therapeutic target in pancreatic ductal adenocarcinoma (PDAC), but success is limited by pathway reactivation, which drives resistance….
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 76
Decoding tumor clonal heterogeneity unravels an unexpected degree of complexity during metastasis formation in pancreatic cancer.
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14
Pancreatic cancer carries the highest mortality rate of all major cancers and is projected to become the second-leading cause of cancer-related deaths in the United States by 2030. It is especially difficult …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
Learn how @ZCMlab and her fellow @OhioState researchers are expanding understanding of obesity's role in #PancreaticCancer, and studying possible ways to improve treatment and quality of life for patients. https://t.co/HMQFrfJij3