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Mashup Score: 39
CD8+ T cells integrate signals from the local microenvironment to establish tissue residency, but which factors are involved and how remain unresolved. Obers et al. highlight the role of retinoic acid (RA) in promoting TRM cell formation across multiple tissues and supporting intestinal TRM cell maintenance by restricting their migration to draining lymph nodes.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5Roflumilast cream 0.15% addresses unmet needs of adults, children with atopic dermatitis - 3 hour(s) ago
Roflumilast cream 0.15% showed high efficacy rates among patients aged 6 years and older with mild to moderate atopic dermatitis, according to a study.“Although the current therapeutic landscape for AD comprises topical steroidal and nonsteroidal medications, unmet treatment needs persist,” Eric L. Simpson, MD, MCR, Frances J. Storrs Medical Dermatology Professor at Oregon Health
Source: www.healio.comCategories: General Medicine News, Allergy-ImmunologyTweet-
#Roflumilast cream 0.15% showed high efficacy rates among patients aged 6 years and older with mild to moderate #atopic #dermatitis. More than 95% of roflumilast-treated patients reported no signs of application site irritation. https://t.co/qwfsgYmpyH https://t.co/VPsoAPmEfK
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Mashup Score: 0
BOSTON — Physicians should not hesitate to conduct oral food challenges for infants and toddlers, according to a presentation at the American College of Allergy, Asthma & Immunology Annual Scientific Meeting.“Don’t be afraid of infant and toddler challenges, and don’t underuse them,” Aikaterini (Katherine) Anagnostou, MD, MSc, PhD, FACAAI, professor of pediatric
Source: www.healio.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Physicians should not hesitate to conduct oral food challenges for infants and toddlers: when parents introduce new foods and are unsure if the child has had a reaction, they may need to bring the child to the clinic for an OFC. https://t.co/ocFX4TbWlk https://t.co/wzJjUy0BwF
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Mashup Score: 0FDA accepts new drug application for donidalorsen - 5 hour(s) ago
The FDA accepted a new drug application for review of donidalorsen, a prophylactic RNA-targeting drug used to prevent hereditary angioedema attacks in patients aged 12 years and older, according to a press release from Ionis.“Hereditary angioedema (HAE) is a rare genetic disease where patients experience recurring and unpredictable attacks of severe swelling, which can be
Source: www.healio.comCategories: General Medicine News, Allergy-ImmunologyTweet-
The #FDA accepted a new drug application for review of #donidalorsen, a prophylactic #RNA-targeting drug used to prevent #hereditary #angioedema attacks in patients aged 12 years and older. https://t.co/S6uAeDwInQ https://t.co/l3t0OhbGEr
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Mashup Score: 0Palmitoleate protects against Lipopolysaccharide-induced Inflammation and Inflammasome Activity - 6 hour(s) ago
Inflammation is part of natural immune defense mechanism against any form of infection or injury. However, prolonged inflammation could perturb cell homeostasis and contribute to the development of metabolic and inflammatory diseases including maternal obesity, diabetes, cardiovascular diseases, and metabolic dysfunction-associated steatotic liver diseases. Polyunsaturated fatty acids have been shown to mitigate inflammatory response by generating specialized pro-resolving lipid mediators which take part in resolution of inflammation.
Source: www.jlr.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Sahoo et al. show that palmitoleate, an omega-7 monounsaturated fatty acid exerts anti-inflammatory properties in response to lipopolysaccharide (LPS)-mediated inflammation. https://t.co/TALug3kX3i
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Mashup Score: 2Eosinophil‐Derived Neurotoxin Determinants and Reference Values in a Swedish Middle‐Aged General Population - 11 hour(s) ago
Click on the article title to read more.
Source: onlinelibrary.wiley.comCategories: General Medicine News, Allergy-ImmunologyTweet-
RT @ClinExpAllergy: New reference values for serum EDN in a healthy middle-aged general population. Article link: https://t.co/5VsausuZva…
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Mashup Score: 6The intraflagellar transport cycle - 15 hour(s) ago
Nature Reviews Molecular Cell Biology – Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the…
Source: www.nature.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Now Online: The intraflagellar transport cycle https://t.co/U71zN0Nvyv https://t.co/OERwPq5x3J
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Mashup Score: 0Out of Breath | NEJM - 16 hour(s) ago
This interactive feature describes a 44-year-old woman with a 2-year history of shortness of breath with minimal exertion, cough, fatigue, and unintentional weight loss. Test your diagnostic and th…
Source: www.nejm.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
NEJM Interactive Case: Out of Breath https://t.co/A6HPubfaPI
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Mashup Score: 6New Sexually Transmitted Fungal Infection Emerges in MSM - 18 hour(s) ago
MMWR described four cases of individuals presenting with rash on the face, buttocks, or genitals.
Source: www.medscape.comCategories: General Medicine News, Allergy-ImmunologyTweet-
A #dermatophyte known as #Trichophyton #mentagrophytes genotype VII (TMVII) has been identified as the cause of an emerging #sexually #transmitted fungal infection in four adults in the United States. https://t.co/ZY4zrslQ6z https://t.co/GddkFVXI0x
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Mashup Score: 138Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes - 19 hour(s) ago
Mechanisms that support long-term CD4+ T cell persistence and function in the face of chronic autoimmune stimulus remain unresolved. Aljobaily et al. demonstrate that epigenetic programming and retention of low TCF1 expression promote autoimmune CD4+ T cell survival and effector function in a murine model of diabetes.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Online now: Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes https://t.co/H7w4WJusuN
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Online now: Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency https://t.co/Kw3HRVz9SQ