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Mashup Score: 41
Cancer-associated fibroblasts (CAFs) are an abundant component of the tumor microenvironment and have been shown to possess critical functions in tumor progression. Although their roles predominantly have been described as tumor-promoting, more recent findings have identified subsets of CAFs with tumor-restraining functions. Accumulating evidence underscores large heterogeneity in fibroblast subsets in which distinct subsets differentially impact the initiation, progression, and metastasis of colorectal cancer.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 11Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis - 5 day(s) ago
Oncogenic gene activation in gastric proenzyme-secreting cells can lead to the carcinogenic process in gastric cancer development. Metabolic changes are essential for precancerous cell lineage progression into cancerous cells.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 17Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis - 7 day(s) ago
Pancreatic cancer inception and early detection remain elusive. Complex cellular crosstalk transforming normal cells toward tumor development by means of novel cell signaling mechanism has been identified as the potential culprit.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 17Histologic Remission in Inflammatory Bowel Disease and Female Fertility: A Nationwide Study - 9 day(s) ago
The findings of this nationwide study suggest that achieving histologic remission of inflammatory bowel disease may improve the chances of conceiving a child, even among women with clinically quiescent disease.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 12A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring - 11 day(s) ago
Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on public health, mainly in shaping mucosal colonization by pathobionts from the Enterobacteriaceae family, remains undetermined due to lack of relevant animal models.
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 23
A small advantage for early initiation of biologics was demonstrated in Crohn’s disease, but this was not the case in ulcerative colitis.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 23Current Issue Table of Contents: Gastroenterology - 14 day(s) ago
Login with your AGA username and password. Volume 165 Issue 2 p307-522,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 24AGA Journals' Editorial Fellowships - 15 day(s) ago
A one-year program designed to equip fellows and early career GIs for a future leadership position in scientific publishing. Fellowships are offered at AGA’s journals Gastroenterology, CGH and CMGH.
Source: gastro.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 24AGA Journals' Editorial Fellowships - 16 day(s) ago
A one-year program designed to equip fellows and early career GIs for a future leadership position in scientific publishing. Fellowships are offered at AGA’s journals Gastroenterology, CGH and CMGH.
Source: gastro.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 9Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Growth in Cholangiocarcinoma - 18 day(s) ago
Proapoptotic tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in human beings, challenging the concept of TRAIL as a potent anticancer agent. Herein, we aimed to define mechanisms by which TRAIL+ cancer cells can leverage noncanonical TRAIL signaling in myeloid-derived suppressor cells (MDSCs) promoting their abundance in murine cholangiocarcinoma (CCA).
Source: www.cmghjournal.orgCategories: General Medicine News, GastroenterologyTweet
Review examines fibroblasts in orchestrating #colorectal tumorigenesis and progression. 🌟 Read the full article here: https://t.co/JjzVNIALaq 🖋️ @researchumcg https://t.co/P27EZYbBnV