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Mashup Score: 10Systemic and Tumor-directed Therapy for Oligometastatic Prostate Cancer: The SOLAR Phase 2 Trial in De Novo Oligometastatic Prostate Cancer - 2 month(s) ago
We conducted a trial in which effective multimodal therapies without long-term castration were combined with the aim of achieving durable remission in patients with de novo oligometastatic prostate cancer. Here we report primary analysis results from SOLAR, a single-arm prospective phase 2 trial of primary tumor–directed therapy, metastasis-directed therapy (MDT) [1], and intensified systemic therapy of limited duration conducted within the Veterans Affairs health care system.
Source: www.europeanurology.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 41When Headlines Harm Patients With Cancer - 4 month(s) ago
This Viewpoint discusses journalists’ responsibility to report study results objectively, without dramatic headlines, to avoid hindering patients’ decision-making about treatments.
Source: jamanetwork.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 20
Real-time intrafraction tracking/gating is an integral component of MRI-guided radiotherapy (MRgRT), and may have contributed to the acute toxicity reduction during prostate stereotactic body radiotherapy (SBRT) observed on the MRgRT-arm of the MIRAGE randomized trial (NCT04384770). Herein we characterized intrafraction prostate motion and assessed gating effectiveness.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet-
@weeloonong @DrSpratticus @SouMyajiT_RO @SeanMcGuireMD @DocJarad @MSteinbergMD The second is a post-hoc analysis of gating on the MIRAGE trial https://t.co/1yRib3aVX9. Here we see that a fair number of patients (30%) had at least one fraction in which 20% or more of the treatment time had the beam held due to motion.
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Mashup Score: 46
A suboptimal prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) among men who go on to receive definitive radiotherapy for prostate cancer might suggest the existence of castration-resistant disease or altered androgen receptor (AR) signaling. This in turn may portend worse long-term clinical outcomes, especially in men with high-risk disease. We set out to evaluate the prognostic impact of poor PSA response to neoadjuvant ADT in men with high-risk prostate cancer.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Effect of Pelvic External Beam Radiation Therapy on Bone Mineral Density: A Secondary Analysis of a Phase III Randomized Controlled Trial - 5 month(s) ago
Pelvic radiotherapy may lead to decreased bone mineral density (BMD) and increased risk of fracture which could be of particular concern in prostate cancer (PCa) patients who also receive androgen deprivation therapy (ADT). We performed exploratory analysis of a randomized, double-blind, placebo-controlled trial to determine if exposure to prior pelvic external beam radiotherapy (XRT) affects BMD and risk of fracture in PCa patients treated with ADT.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Effect of Pelvic External Beam Radiation Therapy on Bone Mineral Density: A Secondary Analysis of a Phase III Randomized Controlled Trial - 6 month(s) ago
Pelvic radiotherapy may lead to decreased bone mineral density (BMD) and increased risk of fracture which could be of particular concern in prostate cancer (PCa) patients who also receive androgen deprivation therapy (ADT). We performed exploratory analysis of a randomized, double-blind, placebo-controlled trial to determine if exposure to prior pelvic external beam radiotherapy (XRT) affects BMD and risk of fracture in PCa patients treated with ADT.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4
The trigone exhibits little volume change, but considerable interfractional displacement/deformation. As a result, the relative volume of the trigone receiving high doses during prostate SBRT varies substantially between fractions, which could influence GU toxicity and may not be predicted by radiat …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 4Urethral Interfractional Geometric and Dosimetric Variations of Prostate Cancer Patients: A Study Using an Onboard MRI - PubMed - 7 month(s) ago
Urethral interfractional motion and anatomic change can result in daily treatment violating urethral constraints. Onboard MRI with good visualization of the prostatic urethra can be a valuable tool to help better protect the urethra through patient setup or online adaptive RT.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 64
Emerging data suggest that trigone dosimetry may be more associated with post-stereotactic body radiotherapy (SBRT) urinary toxicity than whole bladder dosimetry. Herein, we quantify the dosimetric impact of interfractional displacement and deformation of the whole bladder and trigone during prostate SBRT using on-board, pre-treatment 0.35T MRI images.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0
This cohort study assesses prostate cancer–specific mortality and distant metastasis outcomes among men with high-risk prostate cancer treated with radical prostatectomy or external beam radiotherapy with or without brachytherapy boost.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
@ChadTangMD A paired trial, also published in @EUplatinum , was Nick Nickol's SOLAR trial at the Greater LA VA: https://t.co/c8SyQ5vHM8