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Mashup Score: 19Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation - 13 hour(s) ago
Although lifesaving, mechanical ventilation is also associated with iatrogenic complications. Perhaps the best-known examples are ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, but other forms of ventilator-associated iatrogenesis may exist and must be understood to improve outcomes for mechanically ventilated patients. Here, we argue that ventilator-associated brain injury (VABI) merits urgent attention to establish whether brain-protective ventilation strategies could
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 4Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 19 hour(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 2 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 43
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 5
Precise, early detection of microscopic alterations in interstitial lung disease (ILD) is essential for early diagnosis, as well as to inform prognosis and support therapeutic decision making (1 – 3). Unfortunately, resolution limitations of high-resolution computed tomography (HRCT) make the detection and monitoring of microscopic disease challenging (4). Surgical lung biopsy (SLB) has high risks of associated morbidity and mortality, necessitating a cautious approach for diagnosis and prohibiting use
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Mashup Score: 8The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial - 2 day(s) ago
The anti–neutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs) are a group of rare pauci-immune autoimmune diseases that involve inflammation of the small blood vessels (1). Although how and when these antibodies develop remains a mystery, multiple organs can be left with irreversible damage. Biopsies show few or no immunoglobulins and complement deposits. Notable AAVs include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic GPA, drug-induced vasculitis,
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 7Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 3 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial - 3 day(s) ago
Rationale: A phase II trial reported clinical benefit over 28 weeks in patients with idiopathic pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the efficacy and …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 42
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 18
Proof that nintedanib and pirfenidone slow progression of idiopathic pulmonary fibrosis (IPF) has sparked further clinical trials that are being pursued in the hope of curing this devastating disease. This includes the study of pentraxin-2, a liver-synthesized plasma protein with antiinflammatory and antifibrotic properties in in vitro and animal models (1). In this issue of the Journal, Richeldi and colleagues (pp. 1132–1140) report findings of the phase III STARSCAPE randomized controlled trial (RCT)
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
The Blue Journal thanks Thiago Bassi, M.D., Ph.D., for his contribution to the May 15 issue Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation @thiagobassiMD @ecgoligher @chiara_robba https://t.co/u8kBNAl308 https://t.co/HiVtzfqeU9