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Mashup Score: 0
In a 1892 publication, Sir William Osler described difficulty in exhaling as a prominent symptom of asthma, highlighting that expiration was “prolonged and also wheezy” (1). His clinical descriptions marked an early recognition of air trapping (AT) in asthma. Over time, our understanding of AT as a pathophysiological component of asthma has evolved, driven in part by advances in the ways to measure it. In the early 1990s, Webb and colleagues were the first to describe the observation of AT on expiratory
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 1Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 5 hour(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 28Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation - 19 hour(s) ago
Although lifesaving, mechanical ventilation is also associated with iatrogenic complications. Perhaps the best-known examples are ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, but other forms of ventilator-associated iatrogenesis may exist and must be understood to improve outcomes for mechanically ventilated patients. Here, we argue that ventilator-associated brain injury (VABI) merits urgent attention to establish whether brain-protective ventilation strategies could
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 22Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 1 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 1Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 2 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 43
Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 5
Precise, early detection of microscopic alterations in interstitial lung disease (ILD) is essential for early diagnosis, as well as to inform prognosis and support therapeutic decision making (1 – 3). Unfortunately, resolution limitations of high-resolution computed tomography (HRCT) make the detection and monitoring of microscopic disease challenging (4). Surgical lung biopsy (SLB) has high risks of associated morbidity and mortality, necessitating a cautious approach for diagnosis and prohibiting use
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 8The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial - 2 day(s) ago
The anti–neutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAVs) are a group of rare pauci-immune autoimmune diseases that involve inflammation of the small blood vessels (1). Although how and when these antibodies develop remains a mystery, multiple organs can be left with irreversible damage. Biopsies show few or no immunoglobulins and complement deposits. Notable AAVs include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic GPA, drug-induced vasculitis,
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 7Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis - 3 day(s) ago
Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial - 3 day(s) ago
Rationale: A phase II trial reported clinical benefit over 28 weeks in patients with idiopathic pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the efficacy and …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
A Novel Computed Tomography Score Reveals More about Air Trapping in Asthma 🔓 Open Access 🔗 https://t.co/L5DAa3YyC3