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Mashup Score: 325A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children - 1 month(s) ago
Genetic fine-mapping across the IKZF1 gene revealed a variant associated with childhood ALL that contributes to the increased risk of this disease in Hispanic/Latino individuals. The ALL risk allele reduces enhancer activity and IKZF1 expression specifically in B cell progenitors, likely resulting in stalled B cell development and an increased risk of ALL.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 312Deciphering cell states and genealogies of human haematopoiesis - 1 month(s) ago
Nature – An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and…
Source: www.nature.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 24ASCI Perspectives - Courtney Fitzhugh - full interview (March 2024) - 1 month(s) ago
A March 4, 2024, interview in the ASCI Perspectives series between Vijay G. Sankaran, MD, PhD, and Courtney D. Fitzhugh, MD.
Source: vimeo.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 303Deciphering cell states and genealogies of human haematopoiesis - 2 month(s) ago
Nature – An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and…
Source: www.nature.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 20An iron rheostat controls hematopoietic stem cell fate - 2 month(s) ago
The preservation of adult stem cell identity following cell division is essential for sustained tissue maintenance and repair. Will, Kao, and colleagues identify iron as a crucial regulator allowing hematopoietic stem cells to orchestrate metabolic and gene regulatory control during regenerative fate determination.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2
Mohandas Narla, DSc, may hold the title of American Society of Hematology president, but his focus for the next several months will extend far beyond this country’s borders.“Hematology is a global problem. At least 30% of ASH members who come to our meetings are international members,” Narla — whose 1-year term as ASH president continues through December — told
Source: www.healio.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 424Deciphering cell states and genealogies of human hematopoiesis - 3 month(s) ago
Nature – Deciphering cell states and genealogies of human hematopoiesis
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9Schistosome Infection Impacts Hematopoiesis - PubMed - 4 month(s) ago
Helminth infections are common in animals. However, the impact of a helminth infection on the function of hematopoietic stem cells (HSCs) and other hematopoietic cells has not been comprehensively defined. In this article, we describe the hematopoietic response to infection of mice with Schistosoma …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation - 4 month(s) ago
The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fus…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet-
@ZHAOJiawei9 @liamcato @UmaArora16 @erik_bao @Armstrong_dfci @seyvos @Michael_A_Erb @jyoti_nangalia But this was confusing, given that prior work (https://t.co/q45XtuJ9Tn) from Muntean and others had suggested that the PAF1 complex was necessary for blood stem cell function. (9/n) https://t.co/OwMu3IW9jS
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Mashup Score: 4Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells - Nature - 4 month(s) ago
A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
@ZHAOJiawei9 @liamcato @UmaArora16 @erik_bao @Armstrong_dfci @seyvos @Michael_A_Erb @jyoti_nangalia Our prior studies (https://t.co/TahKdpO0hq) had suggested a model whereby variation in blood stem cell self-renewal might alter the risk for developing blood cancers, such as myeloproliferative neoplasms or MPNs. Could something similar be happening here? (7/n) https://t.co/LWfcNndfhm
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Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in @CellGenomics today, led by @adamdesmith, @LWahlster, @SoYoungJeon_Eli, @fulong_yu, @CharlestonCWKC, & colleagues: https://t.co/2QdrGJlbbU https://t.co/FXt9j9Zqck