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Mashup Score: 78New postdoc opportunity: high-content screening to identify new pediatric glioma therapies · Verhaak Lab - 4 month(s) ago
The Verhaak lab is looking to recruit a postdoctoral associate who will help us identify and develop new therapeutic approaches for children with a brain tumor. The ideal candidate has experienceworking with cell line models and cancer biology. Previous work with high-throughput approaches is desirable. First author peer-reviewed papers are… %}
Source: verhaaklab.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 99Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma | NEJM - 4 month(s) ago
Original Article from The New England Journal of Medicine — Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 59cBioPortal for Cancer Genomics - 4 month(s) ago
The cBioPortal for Cancer Genomics provides visualization, analysis and download of large-scale cancer genomics data sets
Source: www.cbioportal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 99Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma | NEJM - 4 month(s) ago
Original Article from The New England Journal of Medicine — Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 99Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma | NEJM - 4 month(s) ago
Original Article from The New England Journal of Medicine — Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 99Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma | NEJM - 4 month(s) ago
Original Article from The New England Journal of Medicine — Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 127The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen - 4 month(s) ago
Abstract. Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator of IDHmut astrocytoma evolution. Furthermore, relapse of IDHmut tumors was accompanied by histological progression that was associated with survival, as validated in an independent cohort. Finally, the initial cell composition of the tumor microenvironment varied between IDHwt and ID
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 99Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma | NEJM - 5 month(s) ago
Original Article from The New England Journal of Medicine — Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 19We are looking for a lab manager · Verhaak Lab - 5 month(s) ago
The Verhaak lab is looking for a new lab manager. We are a group of approximately 12 scientists, who are performing both wet lab as well as dry lab research. Our lab manager makes sure that our wet lab is able to operate effectively and efficiently. The Verhaak lab is… %}
Source: verhaaklab.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 66New postdoc opportunity: high-content screening to identify new pediatric glioma therapies · Verhaak Lab - 5 month(s) ago
The Verhaak lab is looking to recruit a postdoctoral associate who will help us identify and develop new therapeutic approaches for children with a brain tumor. The ideal candidate has experienceworking with cell line models and cancer biology. Previous work with high-throughput approaches is desirable. First author peer-reviewed papers are… %}
Source: verhaaklab.comCategories: General Medicine News, Hem/OncsTweet
Excited to be recruiting new postdocs that will leverage our high-content screening and live-cell imaging platform to discover new therapies for pediatric glioma patients: https://t.co/6o9HEF5e2j. Contact me with questions and for more info!