The primary function of cholesteryl ester transfer protein (CETP) is to facilitate the transfer of cholesteryl esters and triglycerides between lipoproteins. CETP inhibitors reduce the transfer of cholesterol from high-density lipoprotein (HDL) particles to low-density lipoprotein (LDL) and very low-density lipoprotein particles (VLDL). This results in elevated HDL-C levels and a decrease in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) levels.1 Observational studies have demonstrated that certain reduced-function polymorphisms of CETP are associated with a decrease in major adverse cardiovascular events (MACE) and mortality.