• Mashup Score: 21

    Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) from birth, leading to accelerated atherosclerotic cardiovascular disease and premature death if untreated. Evinacumab, a monoclonal antibody targeting angiopoietin-like 3 (ANGPTL3), offers an LDL receptor-independent pathway to lower LDL-C. This study aimed to evaluate the effect of evinacumab on lipid levels and its potential to reduce lipoprotein apheresis (LA) frequency in children and adolescents with HoFH.

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    • #Evinacumab and reduced lipoprotein apheresis in pediatric #HoFJ : a retrospective study on LDL-C - #Atherosclerosis https://t.co/mZDyDkqqOL

  • Mashup Score: 12

    Intraoperative transesophageal echocardiography is used with increasing frequency in cardiac surgery for monitoring and diagnostic purposes. Recent data have shown the impact of improved outcomes in patients undergoing cardiac surgery and the use of intraoperative transesophageal echocardiography in managing complex surgical decisions. However, specialty society recommendations have not been updated to reflect these trends. This scientific statement reviews the state-of-the-art practice of intraoperative echocardiography, summarizes the association of the use of intraoperative transesophageal echocardiography with enhanced outcomes, and provides specific perioperative and procedural transesophageal echocardiography considerations in the cardiac surgical population.

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    • Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement. Not new but useful https://t.co/htETf4UYcj

  • Mashup Score: 11

    Renal and metabolic dysfunction are major contributors to atherosclerotic cardiovascular disease (ASCVD) [1,2]. Although underlying risk factors including chronic kidney disease (CKD), diabetes mellitus (DM), excess visceral adiposity, and dyslipidemia are each independently associated with ASCVD, important mechanistic and clinical synergies exist between these conditions. For instance, in diabetic kidney disease, metabolic stress and related damage-associated molecular patterns trigger inflammatory responses in the kidney and vasculature, leading to tissue damage and related progression of CKD and ASCVD (Graphical Abstract) [3].

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    • Metabolic, renal, and inflammatory crosstalk in #ASCVD : Evolving landscape and future directions - #Atherosclerosis https://t.co/ptSiDuRIsc

  • Mashup Score: 18

    Diabetes mellitus (DM) is a major public health issue and a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), which contributes to up to 80 ​% of deaths in individuals with diabetes.1 The elevated risk is primarily due to hyperglycemia-induced inflammation, oxidative stress, and endothelial dysfunction, leading to increased coronary plaque burden and rupture risk. Coronary Computed Tomography Angiography (CCTA) enables detailed assessment of plaque burden using metrics like Total Plaque Score (TPS), Total Stenosis Score (TSS), and Coronary Artery Calcium (CAC) Score.

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    • The effect of #diabetes on #plaque, stenosis, and #CAC score - https://t.co/uz2jhoqoXh