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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36Use of melatonin supplements and risk of type 2 diabetes and cardiovascular diseases in the USA: insights from three prospective cohort studies - 18 hour(s) ago
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 13Bone mineral density as a surrogate endpoint for fracture risk reduction in clinical trials of osteoporosis therapies: an update on SABRE - 20 hour(s) ago
Launched as a public–private partnership funded by the Foundation for the National Institutes of Health, the Study to Advance Bone Mineral Density as a Regulatory Endpoint (SABRE) aims to change the framework for how clinical trials of new anti-osteoporosis drugs are conducted, to promote innovation in the field of osteoporosis, where underdiagnosis and undertreatment of disease have been deemed a crisis.1 Osteoporosis-related fractures, which lead to high morbidity and increased mortality, are a large and growing public health concern as one in two women and one in five men over the age of 50 years will have a fracture.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 11Familial aggregation and heritability of childhood-onset and adult-onset type 1 diabetes: a Swedish register-based cohort study - 1 day(s) ago
Adult-onset type 1 diabetes seems to have weaker familial aggregation and lower heritability than childhood-onset type 1 diabetes. This finding suggests a larger contribution of environmental factors to the development of type 1 diabetes in adults than in children and highlights the need to identify and intervene on such factors.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 1 day(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 42Air pollution exposure and cardiometabolic risk - 2 day(s) ago
The Global Burden of Disease assessment estimates that 20% of global type 2 diabetes cases are related to chronic exposure to particulate matter (PM) with a diameter of 2·5 μm or less (PM2·5). With 99% of the global population residing in areas where air pollution levels are above current WHO air quality guidelines, and increasing concern in regard to the common drivers of air pollution and climate change, there is a compelling need to understand the connection between air pollution and cardiometabolic disease, and pathways to address this preventable risk factor.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 4Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease - 3 day(s) ago
Despite widespread sex differences in prevalence and presentation of numerous illnesses affecting the human brain, there has been little focus on the effect of endocrine ageing. Most preclinical studies have focused on males only, and clinical studies often analyse data by covarying for sex, ignoring relevant differences between the sexes. This sex- (and gender)-neutral approach is biased and contributes to the absence of targeted treatments and services for all sexes (and genders). Female health has been historically understudied, with grave consequences for their wellbeing and health equity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0
With the increase in obesity prevalence worldwide, considerable efforts have been made to investigate the molecular and neurohormonal mechanisms of bodyweight control, as a means to identify novel therapeutic targets. As a paradigmatic example, characterisation of the physiological actions of glucagon-like peptide-1 (GLP-1) paved the way for development of long-acting GLP-1 analogues that are revolutionising the pharmacological management of obesity.1 Similarly, recognition of the fundamental roles of the leptin–melanocortin system in bodyweight homeostasis has opened up potential pathways to manage some forms of obesity.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
Also read the Linked Comment: #Melatonin: is it really a #cardiovascular wonder pill for shift workers? https://t.co/fssxkVYHOB #T2D #CVD #sleep