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Mashup Score: 0
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 1Shop Talk : Oncology Times - 4 hour(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0
ural inputs onto the mPFC have not been completely explored. Here, we report that the neural terminals from the dorsal hippocampus CA1 (dCA1) form excitatory connection with layer 5 pyramidal neurons in the prelimbic area (PrL) of the mPFC. Spared nerve injury (SNI) induced a reduction in the intrinsic excitability of dCA1 pyramidal neurons innervating the PrL and impairment in excitatory synaptic transmission onto dCA1 pyramidal cells. Specifically, activating the neural circuit from dCA1 to mPFC alleviated neuropathic pain behaviors and improved novel object recognition ability in SNI mice, whereas deactivating this pathway in naïve animals recapitulated tactile allodynia and memory deficits. These results indicated that hypoactivity in dCA1 pyramidal cells after SNI in turn deactivated layer 5 pyramidal neurons in PrL and ultimately caused pain hypersensitivity and memory deficits….
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0Neurology Today - 5 hour(s) ago
Neurology Today reports on breaking news, issues, and trends in the practice and science of neurology, reaching more than 36,000 professionals. It delivers credible, up-to-the-minute, balanced, cutting-edge reporting and commentary for today’s busy neurology professionals. Published in print twice a month with the latest developments and online-only coverage on NeurologyToday.com, Neurology Today also gives readers the inside track to key clinical and basic science advances from the AAN and its official journal, Neurology, as well as other peer-reviewed neurology and medical journals.
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 0Effect of Antibiotic Prophylaxis on Infection Rates in... : JAAOS - Journal of the American Academy of Orthopaedic Surgeons - 6 hour(s) ago
ctive studies have shown no benefit of preoperative antibiotics. There continues to be notable variability in antibiotic usage based on surgeon preference and local institutional policy. We conducted a double-blinded, randomized controlled trial to evaluate whether antibiotic prophylaxis reduces the risk of infection in pediatric SCHF patients treated with CRPP. Methods: Pediatric patients with displaced SCHF who presented to a pediatric hospital were enrolled and randomized into two groups. Group I received one dose of prophylactic antibiotics (25 mg/kg cefazolin IV up to 1g or clindamycin 10 mg/kg up to 600 mg/kg IV in the case of cefazolin allergy). Group II received placebo (10-mL prefilled syringe of normal saline). All patients underwent CRPP and casting followed by pin removal 3 to 6 weeks after the initial procedure. The presence of pin-site infection, erythema, drainage, septic arthritis, and osteomyelitis was recorded. Results: One hundred sixty patients were enrolled in the
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Mashup Score: 0ASN Efforts to Address Challenges Highlighted in Recent... : Journal of the American Society of Nephrology - 7 hour(s) ago
An abstract is unavailable. This article is available as a PDF only.
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Mashup Score: 0Association of Preterm Birth with Adverse Glomerular... : Clinical Journal of the American Society of Nephrology - 7 hour(s) ago
glomerular disease are unknown. Methods: We performed a cross-sectional and longitudinal analysis of participants in the Cure Glomerulonephropathy (CureGN) cohort. Preterm (<37 weeks’ gestation) was compared to term (≥37 weeks’ gestation). A survival analysis and adjusted Cox proportional hazards model were used to examine a composite outcome of 40% decline in estimated glomerular filtration rate (eGFR) or progression to kidney failure. An adjusted logistic regression model was used to examine remission of proteinuria. Results: There were 2,205 term and 235 preterm participants. APOL1 risk alleles were more common in those born preterm. More pediatric than adult participants in CureGN were born preterm: 12.8% vs. 7.69% (P<0.001). Adults born preterm as compared to term had a higher prevalence of Focal Segmental Glomerulosclerosis (FSGS) (35% vs. 25%, P=0.01) and APOL1 high-risk genotype (9.4% vs 4.2%, P=0.01). Participants born preterm had a shorter time interval to a 40% eGFR decline/
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Mashup Score: 2
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4
ural inputs onto the mPFC have not been completely explored. Here, we report that the neural terminals from the dorsal hippocampus CA1 (dCA1) form excitatory connection with layer 5 pyramidal neurons in the prelimbic area (PrL) of the mPFC. Spared nerve injury (SNI) induced a reduction in the intrinsic excitability of dCA1 pyramidal neurons innervating the PrL and impairment in excitatory synaptic transmission onto dCA1 pyramidal cells. Specifically, activating the neural circuit from dCA1 to mPFC alleviated neuropathic pain behaviors and improved novel object recognition ability in SNI mice, whereas deactivating this pathway in naïve animals recapitulated tactile allodynia and memory deficits. These results indicated that hypoactivity in dCA1 pyramidal cells after SNI in turn deactivated layer 5 pyramidal neurons in PrL and ultimately caused pain hypersensitivity and memory deficits….
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0How to Succeed in Modernizing Clinical Trials : Oncology Times - 10 hour(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, Hem/OncsTweet
Via @TheLancetNeurology: A new oral drug for #DuchenneMuscularDystrophy—#givinostat—targets pathological processes to reduce inflammation and fibrosis and slow muscle loss: https://t.co/I8n0bKn6mH #NeuroTwitter @AANMember @UCD_Neurology @Neuroscience_NU https://t.co/nb5Z4nwwGW