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Mashup Score: 9
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2Bridging anatomical gaps between brain and immune system - 4 hour(s) ago
It is increasingly clear that the central nervous system (CNS) relies significantly on both adaptive and innate immune cells for its repair and lifelong maintenance. These interactions hold profound implications for brain aging and neurodegeneration. Recent work by Smyth et al. describes newfound anatomical connections between the brain and dura mater, which they named the arachnoid cuff exit points.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 2Gasdermin D palmitoylation: to cleave or not to cleave? - 4 hour(s) ago
Recent studies have identified Cys191 in gasdermin D (GSDMD) as a highly targeted regulatory module controlling pyroptosis. Using chemical biology and genetic models, Du, Healy et al. recently identified GSDMD palmitoylation as a key regulatory step in GSDMD activation.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 6
An automated method allows for profiling and comparison of embryogenesis phenotypes, based on high-content imaging data. This method provides a ranked list of genes with similar knockdown phenotypes for 500 candidate developmental genes.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 1Metabolic regulation of single synaptic vesicle exo- and endocytosis in hippocampal synapses - 5 hour(s) ago
Synaptic transmission is energetically costly. Myeong et al. demonstrate that hippocampal synapses can bypass glycolysis using oxidative fuels. Mitochondria, rather than glycolysis, control the spatiotemporal properties of vesicle release and ultrafast endocytosis. Mitochondrial localization in nerve terminals enhances vesicle release and reuptake, thus representing a form of synaptic plasticity.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 18N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation - 6 hour(s) ago
The ubiquitin-binding endoribonuclease N4BP1 integrates signals from multiple innate immune receptors to regulate inflammatory cytokine responses. Gitlin et al. find that N4BP1 acts in concert with the noncanonical IκB kinases, TBK1 and IKKε, to suppress late-phase inflammatory gene transcription during Toll-like receptor responses, thereby limiting over-exuberant inflammation.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 0spotlight-inspirational-women-in-biophysics: Biophysical Journal - 7 hour(s) ago
Interviews with five inspirational women in biophysics and published authors in Biophysical Society journals, Biophysical Journal and Biophysical Reports, who describe their career journeys, roadblocks, and motivations and share tips for success, thoughts on gender equity in science, and insights for women scientists. Scripps Research Institute, California University of Virginia School of Medicine, USA Arizona State University and The Biodesign Institute, USA Please could you give us a brief introduction
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 6
(Cell Reports 39, 110675; April 12, 2022)
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 2Partners and guardians of the nervous and immune systems - 8 hour(s) ago
‘Adapt what is useful, reject what is useless, and add what is specifically your own’Bruce Lee
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 5
Multilayered gene regulation orchestrates cell-type-specific cytokine expression. Liu et al. examine the impact of chromatin loop formation on the expression of IFN-γ and IL-22, which are cytokine loci closely located in the genome, and identify an inducible topologically associating domain required for proper IFN-γ production in Th1 cells. Deleting a CTCF-binding site within this domain leads to lineage-specific cytokine dysregulation and increased susceptibility to pathogens.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
Online Now: Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts https://t.co/UiafrcU133 https://t.co/I1XKA4jBNW