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Mashup Score: 4Current Issue Table of Contents: Gastroenterology - 6 hour(s) ago
Login with your AGA username and password. Volume 166 Issue 5 p717-948,
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 14Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma - 1 day(s) ago
Lysyl oxidase expression is enhanced in cholangiocarcinoma tumors and predictive of poor survival. Lysyl oxidase is found mainly in cancer-associated fibroblasts, resident stromal cells responsible for shaping the tumor microenvironment. Lysyl oxidase inactivation in vivo shows diminished cholangiocarcinoma burden in murine livers. Therefore, targeting lysyl oxidase may be a promising therapeutic strategy in cholangiocarcinoma.
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Mashup Score: 21Interleukin 21 Drives a Hypermetabolic State and CD4+ T-Cell–Associated Pathogenicity in Chronic Intestinal Inflammation - 4 day(s) ago
Interleukin 21 induces metabolic alterations and acquisition of an inflammatory-like phenotype by perturbing mitochondria–endoplasmic reticulum crosstalk, thereby diminishing the capacity of Tregs in suppressing inflammatory bowel disease.
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Mashup Score: 17Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention - 6 day(s) ago
This study provides the combined mutational and transcriptomic landscape along with a catalog of immunologically validated neoantigens in Lynch syndrome colonic precancers and tumors that will facilitate cancer immunoprevention strategies.
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Mashup Score: 8Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma - 9 day(s) ago
Identifying metabolic abnormalities that occur before pancreatic ductal adenocarcinoma (PDAC) diagnosis could increase chances for early detection. We collected data on changes in metabolic parameters (glucose, serum lipids, triglycerides; total, low-density, and high-density cholesterol; and total body weight) and soft tissues (abdominal subcutaneous fat [SAT], adipose tissue, visceral adipose tissue [VAT], and muscle) from patients 5 years before the received a diagnosis of PDAC.
Source: www.gastrojournal.orgCategories: General Medicine News, Hem/OncsTweet-
Prior study summary graphic below: Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of #PancreaticCancer https://t.co/EU1QycMkKl Body composition changes especially VAT/SAT changes and biochemical metabolic perturbations (serum lipids and glucose) can… https://t.co/25SA31UDGH https://t.co/ube18aKjx9
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Mashup Score: 11Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis - 11 day(s) ago
Oncogenic gene activation in gastric proenzyme-secreting cells can lead to the carcinogenic process in gastric cancer development. Metabolic changes are essential for precancerous cell lineage progression into cancerous cells.
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Mashup Score: 17Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis - 13 day(s) ago
Pancreatic cancer inception and early detection remain elusive. Complex cellular crosstalk transforming normal cells toward tumor development by means of novel cell signaling mechanism has been identified as the potential culprit.
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Mashup Score: 7Thoracoabdominal Wall Motion–Guided Biofeedback Treatment of Abdominal Distension: A Randomized Placebo-Controlled Trial - 14 day(s) ago
A simple and effective biofeedback technique, guided by the motion of the abdominal and thoracic walls, is introduced to treat abdominal distension in patients with digestive disorders.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 17Histologic Remission in Inflammatory Bowel Disease and Female Fertility: A Nationwide Study - 15 day(s) ago
The findings of this nationwide study suggest that achieving histologic remission of inflammatory bowel disease may improve the chances of conceiving a child, even among women with clinically quiescent disease.
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Mashup Score: 23
A small advantage for early initiation of biologics was demonstrated in Crohn’s disease, but this was not the case in ulcerative colitis.
Source: www.gastrojournal.orgCategories: General Medicine News, GastroenterologyTweet
đź‘‹ Don't forget to check out our May issue, featuring a commentary on the multi-dimensional challenge of poor oral health in #cirrhosis. đź”— https://t.co/ZUyEO1oyz1 https://t.co/EtYGpBOCM5