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Mashup Score: 23Support not stigma: redefining perinatal mental health care - 2 hour(s) ago
Historically, maternal mental health during the perinatal period, which spans from conception to 1 year after birth, is a neglected issue. Up to 85% of women experience so-called baby blues, characterised by symptoms such as prolonged bouts of crying, sadness, and anxiety. Globally, about 10% of pregnant women and 13% of women who have just given birth experience mental disorders, such as depression, anxiety, and psychosis, with higher prevalence observed in low- and middle-income countries. Death by suicide, which is strongly associated with mental health conditions, is a leading cause of mortality during the perinatal period in high-income countries, accounting for 5–20% of maternal deaths.
Source: www.thelancet.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 0
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 8Use of melatonin supplements and risk of type 2 diabetes and cardiovascular diseases in the USA: insights from three prospective cohort studies - 2 hour(s) ago
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 3Urgent considerations for booster vaccination strategies against Ebola virus disease - 2 hour(s) ago
With two endorsed and prophylactic vaccines against Zaire ebolavirus (referred to hereafter as EBOV), the number of individuals vaccinated against EBOV worldwide is estimated to range between 500 000 and 1 000 000 individuals, increasing with every renewed EBOV threat and vaccination campaign. Therefore, re-exposure of previously vaccinated health-care workers, and possibly community members, could become more frequent. In the absence of long-term data on vaccine efficacy and duration of protection, we urgently need to understand revaccination strategies that could maximise the level of protection.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 14Evaluation of a single-dose HPV vaccine strategy for promoting vaccine, health, and gender equity - 3 hour(s) ago
Although several countries have adopted a single-dose human papillomavirus (HPV) vaccination strategy, many other countries continue to include multiple doses in their vaccination programmes. There are ethical reasons to transition to a single-dose strategy. We discuss how a single-dose HPV vaccination strategy advances equity in three dimensions: vaccine equity, health equity, and gender equity. Adopting a single-dose strategy eases pressure on vaccine supply, lowers programme costs, and is easier to distribute.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 3
The Pan-Lassa RDT is not currently recommended as a diagnostic or screening tool for suspected Lassa fever cases. Marked improvement in sensitivity and user friendliness is needed for the RDT to be adopted clinically. There remains an urgent need for better Lassa fever diagnostics to promote safety of in-hospital care and better disease outcomes in low-resource settings.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 0Rapid diagnostic tests for Lassa fever: what do we aim for? - 3 hour(s) ago
Lassa virus (LASV) is a high-consequence pathogen endemic to west Africa that causes annual outbreaks with substantial mortality. Besides transmission from the rodent reservoir to humans, human-to-human transmission can occur through contact with blood and other bodily fluids.1,2
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 13
Pembrolizumab plus chemoradiotherapy did not significantly improve event-free survival compared with chemoradiotherapy alone in a molecularly unselected, locally advanced HNSCC population. No new safety signals were seen. Locally advanced HNSCC remains a challenging disease that requires better treatment approaches.
Source: www.thelancet.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 5The Lancet Respiratory Medicine, August 2023, Volume 11, Issue 8, Pages 663-754, e73-e77 - 4 hour(s) ago
Explore the current issue of The Lancet Respiratory Medicine, a monthly journal covering content in respiratory medicine and critical care
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 3
Vaccination remains the only strategy to generate durable protective immunity against any infectious disease, but data for SARS-CoV-2 vaccination continues to highlight those receiving B-cell depleting therapies, glucocorticoids, and antiproliferative medications such as mycophenolate mofetil as those with the greatest attenuation of immune responses, resulting in an increased risk of breakthrough infections.1 More worrisome is that additional vaccine doses might not seroconvert a large proportion of these patients, particularly those receiving B-cell depleting therapies,2 although many of these observations were done in a small observation study setting.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
Around 10% of pregnant women & 13% of women who have just given birth experience mental disorders, including depression, anxiety & psychosis. An Editorial in @LancetRH_Europe explores maternal mental health in the perinatal period - a neglected issue: https://t.co/EyPOOAdvjQ