-
Mashup Score: 82Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 - 3 hour(s) ago
This study presents the first comprehensive assessment of the global burden of AMR from 1990 to 2021, with results forecasted until 2050. Evaluating changing trends in AMR mortality across time and location is necessary to understand how this important global health threat is developing and prepares us to make informed decisions regarding interventions. Our findings show the importance of infection prevention, as shown by the reduction of AMR deaths in those younger than 5 years. Simultaneously, our results underscore the concerning trend of AMR burden among those older than 70 years, alongside a rapidly ageing global community.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet
-
Mashup Score: 39Direct-to-consumer medical testing: an industry built on fear - 4 hour(s) ago
The direct-to-consumer medical testing industry is booming, with the global market predicted to reach more than US$9 billion by 2033. Genetic tests are increasingly available—with ten new ones entering the market every day—as well as biochemical tests for markers associated with health or disease, devices for monitoring parameters such as blood glucose, and even so-called wellness tests, all of which can be performed without a health professional involved. However, many screening tests sold to the public would not be conducted within a formal health system.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet-
This week's @TheLancet editorial, a hard stance against direct-to-consumer medical testing https://t.co/IfnVNKfXHv https://t.co/fsZZe0mQf2
-
-
Mashup Score: 0
SGLT2 inhibitors did not significantly increase days free of organ support or reduce mortality in patients hospitalised with COVID-19. SGLT2 inhibitors were well tolerated with no observed safety concerns. Overall, these findings do not support the use of SGLT2 inhibitors as standard care in patients hospitalised with COVID-19.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Effect of sodium–glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for #COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, controlled, platform trial https://t.co/lJtMJxcCYR #SGLT2 inhibitors #COVID19
-
-
Mashup Score: 20Bayesian statistics for clinical research - 7 hour(s) ago
Frequentist and Bayesian statistics represent two differing paradigms for the analysis of data. Frequentism became the dominant mode of statistical thinking in medical practice during the 20th century. The advent of modern computing has made Bayesian analysis increasingly accessible, enabling growing use of Bayesian methods in a range of disciplines, including medical research. Rather than conceiving of probability as the expected frequency of an event (purported to be measurable and objective), Bayesian thinking conceives of probability as a measure of strength of belief (an explicitly subjective concept).
Source: www.thelancet.comCategories: General Medicine News, General Journals & SocietTweet-
The rise of modern computing has led to increased accessibility and use of Bayesian statistics in various disciplines, including medical research. A new Review surveys the use of Bayesian methods for the design and analysis of clinical research: https://t.co/U8uxLK5BGc https://t.co/QSL0O5wq5L
-
-
Mashup Score: 4Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 - 8 hour(s) ago
This study presents the first comprehensive assessment of the global burden of AMR from 1990 to 2021, with results forecasted until 2050. Evaluating changing trends in AMR mortality across time and location is necessary to understand how this important global health threat is developing and prepares us to make informed decisions regarding interventions. Our findings show the importance of infection prevention, as shown by the reduction of AMR deaths in those younger than 5 years. Simultaneously, our results underscore the concerning trend of AMR burden among those older than 70 years, alongside a rapidly ageing global community.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet-
Global burden of bacterial AMR 1990–2021: a systematic analysis with forecasts to 2050 @TheLancet m https://t.co/toDgVoEWIJ In 2021, we estimated 4·71 million deaths were associated with bacterial AMR, including 1·14 million deaths attributable to bacterial AMR.
-
-
Mashup Score: 3
Outpatient treatment with metformin reduced long COVID incidence by about 41%, with an absolute reduction of 4·1%, compared with placebo. Metformin has clinical benefits when used as outpatient treatment for COVID-19 and is globally available, low-cost, and safe.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet-
@CIDJournal We also reported less #longcovid In those "who had received at least the primary SARS-CoV-2 vaccine series, 41 (6·6%) of 619 reported a diagnosis of long COVID, compared with 52 (10·3%) of 507 who were unvaccinated." Further reduction in those boosted. https://t.co/LyBZftvmjy
-
-
Mashup Score: 404Understanding the cause of type 2 diabetes - 10 hour(s) ago
Type 2 diabetes has long been thought to have heterogenous causes, even though epidemiological studies uniformly show a tight relationship with overnutrition. The twin cycle hypothesis postulated that interaction of self-reinforcing cycles of fat accumulation inside the liver and pancreas, driven by modest but chronic positive calorie balance, could explain the development of type 2 diabetes. This hypothesis predicted that substantial weight loss would bring about a return to the non-diabetic state, permitting observation of the pathophysiology determining the transition.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Understanding the cause of type 2 #diabetes https://t.co/IeBziX39Ry #overnutrition https://t.co/2CtukBjX8D
-
-
Mashup Score: 6Russia increasingly targeting emergency responders - 10 hour(s) ago
So-called double-tap missile attacks are increasingly being used in Ukraine, where war has already had a devastating impact on health care. Lily Hyde reports.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
“Health should not be a target” So-called double-tap missile attacks are increasingly being used in Ukraine, where war has already had a devastating impact on health care. Find out more in a new World Report from Lily Hyde: https://t.co/MqwHdicm2b
-
-
Mashup Score: 2Frequently asked questions on surrogate endpoints in oncology-opportunities, pitfalls, and the way forward - 10 hour(s) ago
Patients with cancer expect prolonged life (overall survival, OS) or better life (quality of life, QOL) from cancer treatments. However, majority of new cancer drugs are now being approved not based on improved OS or QOL, but based on surrogate endpoints such as tumor shrinkage or delayed tumor progression. These surrogate endpoints, including their validity as a proxy for overall survival, differ based on disease settings and lines of treatment but in general, most surrogate measures have weak correlation with outcomes that matter to patients.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet-
RT @oncology_bg: Everything you wanted to know about surrogate endpoints but were afraid to ask. https://t.co/c0tyzGzHTE @eClinicalMed #E…
-
-
Mashup Score: 83
[177Lu]Lu-PSMA-617 followed by docetaxel improved antitumour activity in patients with de-novo high-volume metastatic hormone-sensitive prostate cancer compared with docetaxel alone, without increased toxic effects. Our data potentially support a role for [177Lu]Lu-PSMA-617 in metastatic hormone-sensitive prostate cancer.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet-
Presented at #ESMO24 and published simultaneously @TheLancetOncol: https://t.co/uXiMcKRXAL The randomised ph2 UpFrontPSMA study: Sequential [177Lu]Lu-PSMA-617 and docetaxel versus docetaxel in patients with metastatic hormone-sensitive #prostatecancer https://t.co/TJybsVLSwE
-
Bacterial antimicrobial resistance, which is steadily increasing, looms as a major threat. This new @IHME_UW report @TheLancet comprehensively reviews the past 3 decades and forecasts out to 2050. https://t.co/7fI3VOgY7Q open-access Much more needs to be done to avert tens of… https://t.co/QuVsfiqMBM https://t.co/Ex0pYtKaJt