-
Mashup Score: 0Moderna ends collaboration with CRISPR company Metagenomi, parts ways with gene editing chief - 1 hour(s) ago
Three years ago, Moderna invested part of its vaccine windfall into a new gene-editing startup, Metagenomi. Now it’s backing out.
Source: www.statnews.comCategories: General Medicine News, General NewsTweet
-
Mashup Score: 2The Mass General Brigham Heart Failure & Shock Course - 1 hour(s) ago
This Comprehensive Mass General Brigham Heart Failure & Shock symposium will provide practical insights for all clinicians who manage patients with heart failure (HF) and cardiogenic shock. This offering is a 2-part course, of which participants can choose to partake in one or both parts. The first half of the course will be an in-depth review of cardiogenic shock while the second half of the course focuses on HF guideline directed medical therapy (GDMT) and beyond – the latest HF innovations with an emphasis on device- and technology-based therapies. Massachusetts General Hospital Faculty and guest speakers who are leaders in the field will address state-of-the-art issues including: up-to-date knowledge of cardiogenic shock pathophysiology, shock phenotypes and trajectories; best practices in shock diagnosis and management; the roles of temporary mechanical circulatory support in shock treatment; emerging heart failure therapies; nuts and bolts of day to day HF management by our APPs
Source: cmecatalog.hms.harvard.eduCategories: General Medicine News, CardiologistsTweet
-
Mashup Score: 0Home-blended gastrostomy-delivered diets can supply similar nutritional intake to commercial formulas in children - 2 hour(s) ago
Commentary on: Fraser LK, Bedendo A, O’Neill M, et al . Safety, resource use and nutritional content of home-blended diets in children who are gastrostomy fed: findings from ‘YourTube’ – a prospective cohort study. Arch Dis Child. 2023:archdischild-2023–3 26 393. Online ahead of print. Gastrostomy tube feeding is a well-established safe and relatively common way of delivering nutrients to the gastrointestinal tract in individual who cannot use the oral route. In children, there are several indications for using chronic gastrostomy tube feeding, including neurodevelopmental conditions, cardiac problems, metabolic conditions, gastrointestinal diseases and malignancy.1 Nutrients delivered through …
Source: ebn.bmj.comCategories: General Medicine News, NursingTweet
-
Mashup Score: 0Frontiers | Don't be a nocebo! Why healthcare organizations should value patients' expectations - 2 hour(s) ago
1 MT3 Clinical Education and Consulting, Coon Rapids, MN, United States 2 Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada 3 Client Experience Company, Los Angeles, CA, United States 4 Department of Medical Sciences, University of Udine, Udine, Italy 5 School of Physiotherapy, University of Verona, Verona, Italy 6 Department of Human Neurosciences, University of Rome “Sapienza Roma”, Rome, Italy 7 Musculoskeletal Pain and Motor Control Research Group, Faculty of Sport
Source: www.frontiersin.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 1Exploring the dynamics of stuttering - 2 hour(s) ago
Seeing is understanding: real-time MRI shows stuttering morphologyDr Daniela Ponssen presents the Clinical Picture study, “Visualising the dynamic morphology…
Source: www.youtube.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 2
A 42-year-old man with a history of an intermittent disorder of speech fluency beginning around the age of 4 years without any obvious triggers attended our unit for further investigation; he had agreed to participate in our MRI study on speech production.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 5
PURPOSE Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment. PATIENTS AND METHODS Patients enrolled in the multicenter, randomized SYNCHRONOUS and CCRe-IV trials were included in the analysis. Patients with colon cancer with synchronous unresectable metastases were randomly assigned at 100 sites in Austria, Germany, and Spain to undergo PTR or up-front chemotherapy (No PTR group). The chemotherapy regimen was left at discretion of the local team. Patients with tumor-related symptoms, inability to tolerate surgery and/or systemic chemotherapy, and history of another cancer were excluded. The primary end point was overall survival (OS
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 0We need to accept that radical life extension is very difficult & unlikely in foreseeable future: Venki Ramakrishnan, Nobel Prize winner - 2 hour(s) ago
I doubt there is such a thing as ‘true’ immortality. Even if scientists were successful in slowing or even reversing aging, those interventions would not be perfect, and gradually the accumulation of damage would prevail, Ramakrishnan said.
Source: www.financialexpress.comCategories: General Medicine News, Partners & KOLsTweet
-
Mashup Score: 12Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications - 2 hour(s) ago
Abstract. Biomarker-driven cancer therapy has revolutionized precision oncology. With a better understanding of tumor biology, tissue-agnostic targets have been characterized and explored, which ultimately led to therapeutics with pan-cancer efficacy. To date, five molecular biomarkers have obtained FDA tissue-agnostic approval for targeted therapies and immunotherapies. Those include BRAFV600E mutations, RET fusions, NTRK fusions, high tumor mutation burden (TMB), and deficient mismatch repair/high microsatellite instability (dMMR/MSI-High). Herein, we have used data from AACR project GENIE to explore the clinico-genomic landscape of these alterations. AACR GENIE is a publicly accessible registry of genomic data from multiple collaborating cancer centers. Current database (version 13.0) includes sequencing data of 168,423 samples collected from patients with different cancers. We were able to identify BRAFV600E, RET fusions, NTRK fusions, and high TMB in 2.9%, 1.6%, 1.5%, and 15.2% of
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 71Walk the Talk Geneva 2024 - 2 hour(s) ago
The Walk the Talk: Health for All Challenge returns on Sunday 26 May 2024 to Geneva, Switzerland to provide a healthy kickstart to the Seventy-seventh World Health Assembly.
Source: www.who.intCategories: General Medicine News, General HCPsTweet-
Get ready! 8 weeks from now, the 5th edition of @WHO’s Walk the Talk for #HealthForAll Challenge will take place. 📍As usual, we will start at Place des Nations, Geneva, and walk, run, roll, dance or play for 2 hours. Here’s how you can register: https://t.co/tc6sD8Qs1Y… https://t.co/FZSmpBESHX https://t.co/2n0wozd7Gc
-
Metagenomi and Moderna break off collaboration after three years of research. https://t.co/99GBICOv19