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Mashup Score: 0
The development of analgesic drugs targeting sodium channels NaV1.7 and NaV1.8 is described. FDA approval of the NaV1.8 antagonist suzetrigine presages an
Source: rupress.orgCategories: General Medicine NewsTweet
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Mashup Score: 1
Broomfield et al. demonstrate that early type I interferon blockade alters CXCR3 chemokine regulation and cell location to promote an antigen-dependent CD8
Source: rupress.orgCategories: General Medicine News, Infectious DiseaseTweet-
💉 Researchers identify the temporal window for type I interferon receptor blockade to drive TCF-1+ stem cell–like memory CD8+ T cell generation following #viral infection and mRNA–lipid nanoparticle vaccination. @JExpMed | https://t.co/0gWO9mmKqI https://t.co/QH2W0Csicy
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Mashup Score: 5Microbiota-centered interventions to boost immune checkpoint blockade therapies | Journal of Experimental Medicine | Rockefeller University Press - 2 month(s) ago
We highlight how the gut microbiome modulates immune checkpoint blockade efficacy in cancer. We outline diagnostic tools for dysbiosis, examine microbiota-
Source: rupress.orgCategories: General Medicine NewsTweet-
Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD: Microbiota-Centered Interventions to Boost Immune Checkpoint Blockade Therapies https://t.co/UztksL2erD @PBarataMD https://t.co/BpNFSv2dxK
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Mashup Score: 0Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans - 2 month(s) ago
Canonically, control of Mycobacterium tuberculosis infection requires a Th1 immune response and IFNγ secretion. Here, noncanonical immunity is identified a
Source: rupress.orgCategories: General Medicine News, Infectious DiseaseTweet-
🫁 Scientists with Drs. Douglas Lauffenburger, @SassettiLab, and Megan Proulx at @UMassChan identified strains that control Mycobacterium #tuberculosis comparably to a standard IFNγ-dependent mouse model but with lower lung IFNγ levels. 🔗 @JExpMed | https://t.co/3S0Q9S2HSm https://t.co/mErIUXfXSX
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Mashup Score: 0Basophils: Regulators of lung inflammation over space and time | Journal of Experimental Medicine | Rockefeller University Press - 8 month(s) ago
Schuijs et al. highlight a novel role for basophils during allergic immune responses to house dust mites (HDM), revealing how interleukin-33 (IL-33)-activa
Source: rupress.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Very interesting. Basophils: Regulators of lung inflammation over space and time https://t.co/02pxQH2Et0
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Mashup Score: 5
Infections with arboviruses Powassan virus (POWV), Usutu virus (USUV), or Ross River virus (RRV) are rare but can cause severe disease. We report autoantib
Source: rupress.orgCategories: General Medicine News, Infectious DiseaseTweet-
🦟 Scientists at @Inserm showed that #autoantibody neutralizing type I interferons underlie an increasing list of severe #arboviral diseases due to Flaviviridae or Togaviridae viruses transmitted to humans by mosquitos or ticks. @JExpMed | https://t.co/CXsqZobp2v https://t.co/zCzm7PLmkM
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Mashup Score: 4
This study demonstrates that early initiation of ART enhances immune selection pressure on HIV-1 reservoir cells and accelerates the accumulation of intact
Source: rupress.orgCategories: General Medicine News, Infectious DiseaseTweet-
🧬 Researchers showed that early ART commencement was frequently associated with accelerated and efficient selection of genome-intact #HIV-1 proviruses in repressive #chromatin locations during the first year after treatment initiation. 💉 @JExpMed | https://t.co/W30TiUOT6O https://t.co/VwxbHM6aNp
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Mashup Score: 29MAIT cells: Conserved watchers on the wall | Journal of Experimental Medicine | Rockefeller University Press - 8 month(s) ago
Our understanding of MAIT cell biology is increasing rapidly. Here, Germain et al. discuss recent findings regarding MAIT cell functions in barrier tissues
Source: rupress.orgCategories: General Medicine News, Hem/OncsTweet-
What are these mysterious evolutionary conserved MAIT cells within mucosa lined tissues? What is their role in dysbiosis sensing & epithelial barrier function? An #OpenAccess review in @JExpMed on MAIT cells. https://t.co/VpguEumbzy https://t.co/MkbCu8xkAa
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Mashup Score: 3
Johnson, Ogishi, and Domingo-Vila et al. describe two siblings with inherited PD-L1 deficiency. Human PD-L1 deficiency underlies early-onset T1D, like PD-1
Source: rupress.orgCategories: General Medicine News, Hem/OncsTweet-
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency | Journal of Experimental Medicine | Rockefeller University Press @OncoAlert https://t.co/4dN5h9oI5h
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Mashup Score: 0The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation - 8 month(s) ago
Lubin, Patel, Mackerodt, and colleagues define the circulating lifespan of conventional human dendritic cells (cDC) at steady state. They show that local i
Source: rupress.orgCategories: General Medicine News, Hem/OncsTweet-
The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation https://t.co/p6OD5ZQfXN
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REVIEW: Sensory neuron sodium channels as #pain targets; from cocaine to #Journavx (VX-548, #suzetrigine) https://t.co/60U759dPjp "There are certainly a range of mechanisms involved in different pain states associated with sensory neurons that reinforce the case for combinatorial https://t.co/lOEs6Of1sW